Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

(2018) William A. Eimer et al.   NEURON

Tau Cleavage at D421 by Caspase-3 is Induced in Neurons and Astrocytes Infected with Herpes Simplex Virus Type 1

(2018) Rodrigo Lerchundi et al.   JOURNAL OF ALZHEIMERS DISEASE

Aging-Related Neurostructural, Neuropathological, and Behavioral Changes Associated with Herpes Simplex Virus Type 1 Brain Infection in Mice

(2018) Fernando Guzman-Sanchez et al.   JOURNAL OF ALZHEIMERS DISEASE

Titers of Herpes Simplex Virus Type 1 Antibodies Positively Correlate with Grey Matter Volumes in Alzheimer's Disease

(2018) Roberta Mancuso et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammatory and Neurodegeneration Markers during Asymptomatic HSV-1 Reactivation

(2018) Carolina Martin et al.   JOURNAL OF ALZHEIMERS DISEASE

Herpes simplex virus type 1 and Alzheimer’s disease: possible mechanisms and signposts

(2017) Ruth F. Itzhaki   FASEB JOURNAL

Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease

(2017) Oriol Busquets et al.   MECHANISMS OF AGEING AND DEVELOPMENT

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

(2017) Daniela Puzzo et al.   eLife

A Novel Method to Titrate Herpes Simplex Virus-1 (HSV-1) Using Laser-Based Scanning of Near-Infrared Fluorophores Conjugated Antibodies

(2017) Marco Fabiani et al.   Frontiers in Microbiology

Evidence that Non-Fibrillar Tau Causes Pathology Linked to Neurodegeneration and Behavioral Impairments

(2017) Kurt R. Brunden et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal Cytoskeletal Dynamic Modification and Neurodegeneration Induced by Infection with Herpes Simplex Virus Type 1

(2017) Ángara Zambrano et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease-Specific Tau Phosphorylation is Induced by Herpes Simplex Virus Type 1

(2017) Matthew A. Wozniak et al.   JOURNAL OF ALZHEIMERS DISEASE

High avidity HSV-1 antibodies correlate with absence of amnestic Mild Cognitive Impairment conversion to Alzheimer’s disease

(2016) Simone Agostini et al.   BRAIN BEHAVIOR AND IMMUNITY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model

(2016) Karine Bourgade et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Herpes Simplex Virus-Type1 (HSV-1) Impairs DNA Repair in Cortical Neurons

(2016) Giovanna De Chiara et al.   Frontiers in Aging Neuroscience

Anodal transcranial direct current stimulation boosts synaptic plasticity and memory in mice via epigenetic regulation of Bdnf expression

(2016) Maria Vittoria Podda et al.   Scientific Reports

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

(2016) M. Fá et al.   Scientific Reports

Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity

(2016) Philipp Spitzer et al.   Scientific Reports

Reactivated herpes simplex infection increases the risk of Alzheimer's disease

(2015) Hugo Lövheim et al.   Alzheimers & Dementia

Assessing rodent hippocampal involvement in the novel object recognition task. A review

(2015) Sarah J. Cohen et al.   BEHAVIOURAL BRAIN RESEARCH

Herpes simplex virus type 1 infection in neurons leads to production and nuclear localization of APP intracellular domain (AICD): implications for Alzheimer’s disease pathogenesis

(2015) Livia Civitelli et al.   JOURNAL OF NEUROVIROLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice

(2015) Cheril Tapia-Rojas et al.   Molecular Neurodegeneration

Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation

(2015) Roberto Piacentini et al.   Scientific Reports

Lytic Gene Expression Is Frequent in HSV-1 Latent Infection and Correlates with the Engagement of a Cell-Intrinsic Transcriptional Response

(2014) Joel Z. Ma et al.   PLoS Pathogens

HSV-1 and Alzheimer’s disease: more than a hypothesis

(2014) Roberto Piacentini et al.   Frontiers in Pharmacology

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model

(2013) Manuela Polydoro et al.   ACTA NEUROPATHOLOGICA

Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer’s disease

(2012) Nobuyuki Kobayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Binding Sites on Tau Proteins as Components for Antimicrobial Peptides

(2012) NAHOKO KOBAYASHI et al.   BIOCONTROL SCIENCE

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

(2012) Dimitrije Krstic et al.   Journal of Neuroinflammation

Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells

(2012) Gema Álvarez et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Infectious Agents and Neurodegeneration

(2012) Giovanna De Chiara et al.   MOLECULAR NEUROBIOLOGY

A cultured affair: HSV latency and reactivation in neurons

(2012) Angus C. Wilson et al.   TRENDS IN MICROBIOLOGY

Herpes simplex virus encephalitis: new infection or reactivation?

(2011) Israel Steiner   CURRENT OPINION IN NEUROLOGY

Proteolytic processing of Alzheimer’s β-amyloid precursor protein

(2011) Han Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells

(2011) Soraya Santana et al.   NEUROBIOLOGY OF AGING

HSV-1 promotes Ca2+-mediated APP phosphorylation and Aβ accumulation in rat cortical neurons

(2010) Roberto Piacentini et al.   NEUROBIOLOGY OF AGING

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

APP Intracellular Domain Impairs Adult Neurogenesis in Transgenic Mice by Inducing Neuroinflammation

(2010) Kaushik Ghosal et al.   PLoS One

APP Processing Induced by Herpes Simplex Virus Type 1 (HSV-1) Yields Several APP Fragments in Human and Rat Neuronal Cells

(2010) Giovanna De Chiara et al.   PLoS One

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study

(2008) Luc Letenneur et al.   PLoS One