The MHC Class-I Transactivator NLRC5: Implications to Cancer Immunology and Potential Applications to Cancer Immunotherapy

Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer

(2020) Qingchuan Zhao et al.   Cancer Immunology Research

Innate Immune Molecule NLRC5 Protects Mice From Helicobacter-induced Formation of Gastric Lymphoid Tissue

(2020) Michelle Chonwerawong et al.   GASTROENTEROLOGY

NLRC5 promotes cell migration and invasion by activating the PI3K/AKT signaling pathway in endometrial cancer

(2020) Yijun Fan et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity

(2020) Lauren K. Zebertavage et al.   Scientific Reports

IFN-λ Enhances Constitutive Expression of MHC Class I Molecules on Thymic Epithelial Cells

(2020) Mohamed Benhammadi et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Therapies for Cancer

(2020) Susan E. Bates   NEW ENGLAND JOURNAL OF MEDICINE

PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity

(2020) Hyungsoo Kim et al.   Science Translational Medicine

Restoration of MHC-I on Tumor Cells by Fhit Transfection Promotes Immune Rejection and Acts as an Individualized Immunotherapeutic Vaccine

(2020) María Pulido et al.   Cancers

Challenges and Opportunities for Pancreatic Cancer Immunotherapy

(2020) Adham S. Bear et al.   CANCER CELL

Arid2-IR promotes NF-κB-mediated renal inflammation by targeting NLRC5 transcription

(2020) Puhua Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma

(2020) Anusha Kalbasi et al.   Science Translational Medicine

Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas

(2020) Devin Dersh et al.   IMMUNITY

Bladder Cancer

(2020) Andrew T. Lenis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NLRC5 promotes transcription of BTN3A1-3 genes and Vγ9Vδ2 T cell-mediated killing

(2020) Anh Thu Dang et al.   iScience

Overall survival by clinical risk category for high dose interleukin-2 (HD IL-2) treated patients with metastatic renal cell cancer (mRCC): data from the PROCLAIMSM registry

(2019) M. Fishman et al.   Journal for ImmunoTherapy of Cancer

Casting a wider net: Immunosurveillance by nonclassical MHC molecules

(2019) M. Patricia D’Souza et al.   PLoS Pathogens

Oncolytic viruses: overcoming translational challenges

(2019) Jordi Martinez-Quintanilla et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRC5 deficiency has a moderate impact on immunodominant CD 8 + T‐cell responses during rotavirus infection of adult mice

(2019) Tian Sun et al.   IMMUNOLOGY AND CELL BIOLOGY

HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis

(2019) Palsamy Periyasamy et al.   BRAIN BEHAVIOR AND IMMUNITY

Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells

(2019) Takahiro Kamiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Knockdown of LncRNA SCAMP1 suppressed malignant biological behaviours of glioma cells via modulating miR-499a-5p/LMX1A/NLRC5 pathway

(2019) Zheqi Zong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8+ Tumor-Infiltrating T Lymphocyte Responses

(2019) Megat Abd Hamid et al.   Cancer Immunology Research

Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease

(2019) Aleksandra Antonczyk et al.   Frontiers in Immunology

The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

(2019) Heng Lin et al.   Frontiers in Immunology

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

(2019) Marian L. Burr et al.   CANCER CELL

Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

(2019) Nicolas Jacquelot et al.   CELL RESEARCH

Mobilizing unconventional T cells

(2019) Tom H. M. Ottenhoff et al.   SCIENCE

miR-4319 suppresses the growth of esophageal squamous cell carcinoma via targeting NLRC5

(2019) Xiao Hu et al.   Current Molecular Pharmacology

Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells

(2018) Brian J. Morrison et al.   BMC CANCER

Quiescent Tissue Stem Cells Evade Immune Surveillance

(2018) Judith Agudo et al.   IMMUNITY

The expanding role of murine class Ib MHC in the development and activation of Natural Killer cells

(2018) Katharine J. Goodall et al.   MOLECULAR IMMUNOLOGY

Epigenome-based cancer risk prediction: rationale, opportunities and challenges

(2018) Martin Widschwendter et al.   Nature Reviews Clinical Oncology

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms of BCG immunotherapy and its outlook for bladder cancer

(2018) Caroline Pettenati et al.   Nature Reviews Urology

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

(2018) Pierre Vantourout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer epigenetics: Moving forward

(2018) Angela Nebbioso et al.   PLoS Genetics

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

(2018) Flávia Castro et al.   Frontiers in Immunology

Complex pattern of immune evasion in MSI colorectal cancer

(2018) Mine Ozcan et al.   OncoImmunology

Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance

(2018) Megha Budhwani et al.   Frontiers in Oncology

The obligate intracellular bacterium Orientia tsutsugamushi targets NLRC5 to modulate the MHC class-I pathway

(2018) Kyle G. Rodino et al.   INFECTION AND IMMUNITY

The Interferon-Gamma Paradox in Cancer

(2018) M. Raza Zaidi   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Global Identification of Post-Translationally Spliced Peptides with Neo-Fusion

(2018) Zach Rolfs et al.   JOURNAL OF PROTEOME RESEARCH

Cancer immunologists scoop medicine Nobel prize

(2018) Heidi Ledford et al.   NATURE

Adoptive cellular therapies: the current landscape

(2018) Maartje W. Rohaan et al.   VIRCHOWS ARCHIV

High Expression of NLRC5 is associated with prognosis of gastric cancer

(2018) Yuemei Li et al.   Open Medicine

NLRC5 mediates cell proliferation, migration, and invasion by regulating the Wnt/β-catenin signalling pathway in clear cell renal cell carcinoma

(2018) Qin Wang et al.   CANCER LETTERS

MARCH9-mediated ubiquitination regulates MHC I export from the TGN

(2017) Francesca De Angelis Rigotti et al.   IMMUNOLOGY AND CELL BIOLOGY

Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8 + T Cell Function and Impaired Viral Clearance

(2017) Christopher R. Lupfer et al.   JOURNAL OF VIROLOGY

The SysteMHC Atlas project

(2017) Wenguang Shao et al.   NUCLEIC ACIDS RESEARCH

Costimulation, a surprising connection for immunotherapy

(2017) Derek L. Clouthier et al.   SCIENCE

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

(2017) Pornpimol Charoentong et al.   Cell Reports

NLRC5 Functions beyond MHC I Regulation—What Do We Know So Far?

(2017) Szilvia Benkő et al.   Frontiers in Immunology

An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes: Is There Relevance for Vaccine Development?

(2017) Anouk C. M. Platteel et al.   Frontiers in Immunology

The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy

(2017) Sourav Paul et al.   Frontiers in Immunology

Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications

(2017) Martina Musella et al.   OncoImmunology

The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores

(2017) Oliver Willhoft et al.   Scientific Reports

Characterization of theNLRC5promoter in chicken: SNPs, regulatory elements and CpG islands

(2016) X. M. Guo et al.   ANIMAL GENETICS

Epigenetic Therapeutics: A New Weapon in the War Against Cancer

(2016) Nita Ahuja et al.   Annual Review of Medicine

NLRC5 regulates cell proliferation, migration and invasion in hepatocellular carcinoma by targeting the Wnt/β-catenin signaling pathway

(2016) Yun-yun Peng et al.   CANCER LETTERS

Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy

(2016) Xiaohong Wang et al.   CANCER RESEARCH

Hide-and-seek: the interplay between cancer stem cells and the immune system

(2016) Mohammad Sultan et al.   CARCINOGENESIS

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

(2016) Joseph L. Benci et al.   CELL

The urgent need to recover MHC class I in cancers for effective immunotherapy

(2016) Federico Garrido et al.   CURRENT OPINION IN IMMUNOLOGY

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

(2016) Jonathan M. Pitt et al.   IMMUNITY

miR-34a and its novel target, NLRC5, are associated with HPV16 persistence

(2016) Jinyuan Li et al.   INFECTION GENETICS AND EVOLUTION

Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes

(2016) Kerstin Sarter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell Priming by ActivatedNlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels

(2016) Giorgia Rota et al.   JOURNAL OF IMMUNOLOGY

NLRC5/MHC class I transactivator is a target for immune evasion in cancer

(2016) Sayuri Yoshihama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A large fraction of HLA class I ligands are proteasome-generated spliced peptides

(2016) Juliane Liepe et al.   SCIENCE

NLRC5 promotes cell proliferation via regulating the AKT/VEGF-A signaling pathway in hepatocellular carcinoma

(2016) Ying-hua He et al.   TOXICOLOGY

Epigenome Editing: State of the Art, Concepts, and Perspectives

(2016) Goran Kungulovski et al.   TRENDS IN GENETICS

NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

(2016) Kristina Ludigs et al.   Nature Communications

Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames

(2016) Céline M. Laumont et al.   Nature Communications

IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages

(2016) Yu Qiao et al.   Cell Reports

NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8+ T lymphocytes

(2016) Galaxia M. Rodriguez et al.   OncoImmunology

Novel technologies and emerging biomarkers for personalized cancer immunotherapy

(2016) Jianda Yuan et al.   Journal for ImmunoTherapy of Cancer

Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes

(2016) F. Ebstein et al.   Scientific Reports

The transporter associated with antigen processing: a key player in adaptive immunity

(2015) Sabine Eggensperger et al.   BIOLOGICAL CHEMISTRY

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

(2015) Nicole Stopa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Immunogenic peptide discovery in cancer genomes

(2015) Alexandra Snyder et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The nature of self for T cells—a systems-level perspective

(2015) Diana P Granados et al.   CURRENT OPINION IN IMMUNOLOGY

Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch

(2015) Qingcai Meng et al.   JOURNAL OF CELL BIOLOGY

A feedforward loop of NLRC5 (de)ubiquitination keeps IKK–NF-κB in check

(2015) Yinling Hu   JOURNAL OF CELL BIOLOGY

Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma

(2015) Dirk Schadendorf et al.   JOURNAL OF CLINICAL ONCOLOGY

Loss of tapasin correlates with diminished CD8+ T-cell immunity and prognosis in colorectal cancer

(2015) Lena Sokol et al.   Journal of Translational Medicine

Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation

(2015) Qin Zhou et al.   MOLECULAR THERAPY

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

NOD-Like Receptors: Versatile Cytosolic Sentinels

(2015) Vinicius Motta et al.   PHYSIOLOGICAL REVIEWS

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

NLRC5 expression in tumors and its role as a negative prognostic indicator in stage III non-small-cell lung cancer patients

(2015) XIAOYU LI et al.   Oncology Letters

NLRC5 Exclusively Transactivates MHC Class I and Related Genes through a Distinctive SXY Module

(2015) Kristina Ludigs et al.   PLoS Genetics

Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells

(2015) S. Van Lint et al.   Cancer Immunology Research

Intratumoral delivery of mRNA: Overcoming obstacles for effective immunotherapy

(2015) Kevin Van der Jeught et al.   OncoImmunology

Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression

(2015) Roberto Bellucci et al.   OncoImmunology

Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus

(2015) Sharon A. Chung et al.   PLoS One

Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes

(2015) Veronika Vlková et al.   Oncotarget

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity

(2015) Kevin Van der Jeught et al.   Oncotarget

Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers

(2015) Huili Li et al.   Oncotarget

Unusual Structural Features Revealed by the Solution NMR Structure of the NLRC5 Caspase Recruitment Domain

(2014) Petrus G. M. Gutte et al.   BIOCHEMISTRY

NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection

(2014) Priya Ranjan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type I Interferon Protects Antiviral CD8+ T Cells from NK Cell Cytotoxicity

(2014) Haifeng C. Xu et al.   IMMUNITY

The N-Terminal Domain of NLRC5 Confers Transcriptional Activity for MHC Class I and II Gene Expression

(2014) Andreas Neerincx et al.   JOURNAL OF IMMUNOLOGY

Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors

(2014) L. C. Anton et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antibody validation of immunohistochemistry for biomarker discovery: Recommendations of a consortium of academic and pharmaceutical based histopathology researchers

(2014) William J. Howat et al.   METHODS

Garbage in, garbage out: A critical evaluation of strategies used for validation of immunohistochemical biomarkers

(2014) Gillian O'Hurley et al.   Molecular Oncology

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Type I Interferons as Regulators of Human Antigen Presenting Cell Functions

(2014) Sandra Gessani et al.   Toxins

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

Cancer Stem Cell Immunology: Key to Understanding Tumorigenesis and Tumor Immune Escape?

(2014) Valentin S. Bruttel et al.   Frontiers in Immunology

Rhinovirus-Induced Calcium Flux Triggers NLRP3 and NLRC5 Activation in Bronchial Cells

(2013) Kathy Triantafilou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Protein quality control and elimination of protein waste: The role of the ubiquitin–proteasome system

(2013) Ingo Amm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors

(2013) Madeleine SQ Kortenhorst et al.   Epigenetics

Immunology of cancer stem cells in solid tumours. A review

(2013) Cristina Maccalli et al.   EUROPEAN JOURNAL OF CANCER

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

MHC Class I Antigen Processing and Presenting Machinery: Organization, Function, and Defects in Tumor Cells

(2013) P. Leone et al.   JNCI-Journal of the National Cancer Institute

Blocking oncogenic RAS enhances tumour cell surface MHC class I expression but does not alter susceptibility to cytotoxic lymphocytes

(2013) Jehan J. El-Jawhari et al.   MOLECULAR IMMUNOLOGY

Immunotherapy-induced CD8+ T Cells Instigate Immune Suppression in the Tumor

(2013) A J Robert McGray et al.   MOLECULAR THERAPY

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

(2013) Paul F Robbins et al.   NATURE MEDICINE

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

The MHC I loading complex: a multitasking machinery in adaptive immunity

(2013) Sabine Hulpke et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Salmonella Type III Effector SspH2 Specifically Exploits the NLR Co-chaperone Activity of SGT1 to Subvert Immunity

(2013) Amit P. Bhavsar et al.   PLoS Pathogens

Expression regulation and function of NLRC5

(2013) Yikun Yao et al.   Protein & Cell

Blockade of PD-1 immunosuppression boosts CAR T-cell therapy

(2013) Liza B John et al.   OncoImmunology

Harnessing the Power of the Immune System to Target Cancer

(2012) Gregory Lizée et al.   Annual Review of Medicine

The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity

(2012) Torsten B. Meissner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens

(2012) Yikun Yao et al.   CELL RESEARCH

Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice

(2012) Yanzheng Tong et al.   CELL RESEARCH

Regulation of Class I Major Histocompatibility Complex (MHC) by Nucleotide-binding Domain, Leucine-rich Repeat-containing (NLR) Proteins

(2012) Gregory R. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRC5 Controls Basal MHC Class I Gene Expression in an MHC Enhanceosome-Dependent Manner

(2012) A. Neerincx et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells

(2012) F. Staehli et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Impaired MHC Class I Expression in Mice Deficient for Nlrc5/Class I Transactivator

(2012) A. Biswas et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Cooperates with the RFX Transcription Factor Complex To Induce MHC Class I Gene Expression

(2012) T. B. Meissner et al.   JOURNAL OF IMMUNOLOGY

The tumour suppressor Fhit positively regulates MHC class I expression on cancer cells

(2012) Irene Romero et al.   JOURNAL OF PATHOLOGY

Chemotherapeutics and Radiation Stimulate MHC Class I Expression through Elevated Interferon-beta Signaling in Breast Cancer Cells

(2012) Shan Wan et al.   PLoS One

The role of classical and non-classical HLA class I antigens in human tumors

(2012) Juergen Bukur et al.   SEMINARS IN CANCER BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Association of IFN-  Signal Transduction Defects with Impaired HLA Class I Antigen Processing in Melanoma Cell Lines

(2011) A. Respa et al.   CLINICAL CANCER RESEARCH

Strategies to counteract MHC-I defects in tumors

(2011) Margit H Lampen et al.   CURRENT OPINION IN IMMUNOLOGY

NLRC5: a newly discovered MHC class I transactivator (CITA)

(2011) Torsten B. Meissner et al.   MICROBES AND INFECTION

Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection

(2011) Linda M. Wakim et al.   NATURE

Expression Regulation of Major Histocompatibility Complex Class I and Class II Encoding Genes

(2011) Peter J. van den Elsen   Frontiers in Immunology

The escape of cancer from T lymphocytes: immunoselection of MHC class I loss variants harboring structural-irreversible “hard” lesions

(2010) Federico Garrido et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Modulation of T-Cell Activation by Malignant Melanoma Initiating Cells

(2010) T. Schatton et al.   CANCER RESEARCH

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

(2010) Jun Cui et al.   CELL

Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients

(2010) T. Di Tomaso et al.   CLINICAL CANCER RESEARCH

What is new with Nods?

(2010) Joao G Magalhaes et al.   CURRENT OPINION IN IMMUNOLOGY

Activating and inhibitory receptors of natural killer cells

(2010) Hollie J Pegram et al.   IMMUNOLOGY AND CELL BIOLOGY

“Hard” and “soft” lesions underlying the HLA class I alterations in cancer cells: Implications for immunotherapy

(2010) Federico Garrido et al.   INTERNATIONAL JOURNAL OF CANCER

A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses

(2010) Andreas Neerincx et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of an E3 Ligase-E2-Ubiquitin Complex Increases Cell Surface MHC Class I Expression

(2010) L. M. Duncan et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Limits the Activation of Inflammatory Pathways

(2010) S. Benko et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NLRC5-Dependent Activation of the Inflammasome

(2010) B. K. Davis et al.   JOURNAL OF IMMUNOLOGY

The Nucleotide-Binding Oligomerization Domain-Like Receptor NLRC5 Is Involved in IFN-Dependent Antiviral Immune Responses

(2010) Sven Kuenzel et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections

(2010) H. Kumar et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Mechanisms Regulate MHC and Antigen Processing Molecules in Human Embryonic and Induced Pluripotent Stem Cells

(2010) Beatriz Suárez-Álvarez et al.   PLoS One

Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity

(2010) A. C. Y. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

(2010) T. B. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Priming of immune responses against transporter associated with antigen processing (TAP)-deficient tumours: tumour direct priming

(2009) Xiao-Lin Li et al.   IMMUNOLOGY

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Efficient Recovery of HLA Class I Expression in Human Tumor Cells After Beta2-Microglobulin Gene Transfer Using Adenoviral Vector: Implications for Cancer Immunotherapy

(2009) A. B. del Campo et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Efficient Internalization of MHC I Requires Lysine-11 and Lysine-63 Mixed Linkage Polyubiquitin Chains

(2009) Jessica M. Boname et al.   TRAFFIC

Molecular mechanisms of MHC class I abnormalities and APM components in human tumors

(2008) Barbara Seliger   CANCER IMMUNOLOGY IMMUNOTHERAPY

Epigenetic Enhancement of Antigen Processing and Presentation Promotes Immune Recognition of Tumors

(2008) A. F. Setiadi et al.   CANCER RESEARCH

Combining the Antigen Processing Components TAP and Tapasin Elicits Enhanced Tumor-Free Survival

(2008) Y. Lou et al.   CLINICAL CANCER RESEARCH

Analysis of HLA class I expression in progressing and regressing metastatic melanoma lesions after immunotherapy

(2008) Rafael Carretero et al.   IMMUNOGENETICS

HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance

(2008) M Campoli et al.   ONCOGENE