Complex pattern of immune evasion in MSI colorectal cancer

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1

(2017) Anita Sveen et al.   Genome Medicine

High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer

(2017) Jonas Janikovits et al.   OncoImmunology

Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion

(2017) Lee A. Albacker et al.   PLoS One

Mouse models of DNA mismatch repair in cancer research

(2016) Kyeryoung Lee et al.   DNA REPAIR

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade

(2016) Valerie Lee et al.   ONCOLOGIST

NLRC5/MHC class I transactivator is a target for immune evasion in cancer

(2016) Sayuri Yoshihama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

(2016) Marios Giannakis et al.   Cell Reports

NLRC5, a promising new entry in tumor immunology

(2016) Sonia T. Chelbi et al.   Journal for ImmunoTherapy of Cancer

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer

(2015) Fabian Echterdiek et al.   OncoImmunology

Clinical significance of microsatellite instability in colorectal cancer

(2013) Matthias Kloor et al.   LANGENBECKS ARCHIVES OF SURGERY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations

(2013) Yuan Ren et al.   Scientific Reports

NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens

(2012) Yikun Yao et al.   CELL RESEARCH

Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice

(2012) Yanzheng Tong et al.   CELL RESEARCH

Regulation of Class I Major Histocompatibility Complex (MHC) by Nucleotide-binding Domain, Leucine-rich Repeat-containing (NLR) Proteins

(2012) Gregory R. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic impact of β-2-microglobulin expression in colorectal cancers stratified by mismatch repair status

(2012) Viktor Hendrik Koelzer et al.   JOURNAL OF CLINICAL PATHOLOGY

NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells

(2012) F. Staehli et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Impaired MHC Class I Expression in Mice Deficient for Nlrc5/Class I Transactivator

(2012) A. Biswas et al.   JOURNAL OF IMMUNOLOGY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

The Predictive Value of HLA Class I Tumor Cell Expression and Presence of Intratumoral Tregs for Chemotherapy in Patients with Early Breast Cancer

(2010) E. M. de Kruijf et al.   CLINICAL CANCER RESEARCH

Hereditary and Familial Colon Cancer

(2010) Kory W. Jasperson et al.   GASTROENTEROLOGY

Immune evasion of microsatellite unstable colorectal cancers

(2010) Matthias Kloor et al.   INTERNATIONAL JOURNAL OF CANCER

The immune response to sporadic colorectal cancer in a novel mouse model

(2010) M Czéh et al.   ONCOGENE

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

(2010) T. B. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology

(2009) Stefan M. Woerner et al.   NUCLEIC ACIDS RESEARCH