The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

(2020) Danja J. Den Hartogh et al.   Nutrients

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

(2020) Stéphane Demine et al.   Stem Cell Research & Therapy

Peroxiredoxin 1 plays a primary role in protecting pancreatic β-cells from hydrogen peroxide and peroxynitrite

(2020) Jennifer S. Stancill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice

(2020) Qinglei Yin et al.   Nature Communications

Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells

(2020) Yunxia Zhu et al.   Frontiers in Endocrinology

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes

(2020) Justin Hou Ming Yung et al.   Cells

AMPK Profiling in Rodent and Human Pancreatic Beta-Cells under Nutrient-Rich Metabolic Stress

(2020) Thierry Brun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes

(2020) Xinzhi Li et al.   MOLECULAR THERAPY

Relationships among pancreatic beta cell function, the Nrf2 pathway, and IRS2: a cross-sectional study

(2020) Yiying Liu et al.   POSTGRADUATE MEDICINE

Pancreatic β-cells detoxify H2O2 through the peroxiredoxin/thioredoxin antioxidant system

(2019) Jennifer S. Stancill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liraglutide prevents β-cells apoptosis via inactivation of NOX2 and its related signaling pathway

(2019) Min Ding et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

The Distinct Effects of Palmitic and Oleic Acid on Pancreatic Beta Cell Function: The Elucidation of Associated Mechanisms and Effector Molecules

(2019) Miruna Nemecz et al.   Frontiers in Pharmacology

Palmitate is not an effective fuel for pancreatic islets and amplifies insulin secretion independent of calcium release from endoplasmic reticulum

(2019) Iok Teng Kuok et al.   Islets

JUND regulates pancreatic β cell survival during metabolic stress

(2019) Austin L. Good et al.   Molecular Metabolism

Oxidative stress pathways in pancreatic beta cells and insulin sensitive cells and tissues - importance to cell metabolism, function and dysfunction

(2019) Philip Newsholme et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells

(2019) Fabio Arturo Grieco et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1/Parkin-dependent mitophagy

(2019) Tian Guo et al.   Cell Death & Disease

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

(2019) Elizabeth Haythorne et al.   Nature Communications

mTORC1-to-AMPK switching underlies β cell metabolic plasticity during maturation and diabetes

(2019) Rami Jaafar et al.   JOURNAL OF CLINICAL INVESTIGATION

β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes

(2019) Laura I. Hudish et al.   JOURNAL OF CLINICAL INVESTIGATION

Linderane protects pancreatic β cells from streptozotocin (STZ)-induced oxidative damage

(2019) Haijun Zhang et al.   LIFE SCIENCES

Involvement of Estrogen Receptor-α in the Activation of Nrf2-Antioxidative Signaling Pathways by Silibinin in Pancreatic β-Cells

(2019) Chun Chu et al.   Biomolecules & Therapeutics

Nutrient Metabolism, Subcellular Redox State, and Oxidative Stress in Pancreatic Islets and β-Cells

(2019) Leticia P. Roma et al.   JOURNAL OF MOLECULAR BIOLOGY

The relevance of AMP-activated protein kinase in insulin-secreting β cells: a potential target for improving β cell function?

(2019) Tomasz Szkudelski et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Nrf2 Activation Protects Mouse Beta Cells from Glucolipotoxicity by Restoring Mitochondrial Function and Physiological Redox Balance

(2019) Johanna Schultheis et al.   Oxidative Medicine and Cellular Longevity

Ficus carica leaves extract inhibited pancreatic β-cell apoptosis by inhibiting AMPK/JNK/caspase-3 signaling pathway and antioxidation

(2019) Yin Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells

(2019) Arwa Alnahdi et al.   PLoS One

NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction.

(2018) Marina Sokolova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells

(2018) Amin Ardestani et al.   Cell Metabolism

The Global Epidemic of the Metabolic Syndrome

(2018) Mohammad G. Saklayen   CURRENT HYPERTENSION REPORTS

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response

(2018) Michelle R. Marasco et al.   DIABETES

MiR-184 expression is regulated by AMPK in pancreatic islets

(2018) Aida Martinez-Sanchez et al.   FASEB JOURNAL

The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes

(2018) Kira Meyerovich et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

ROS‑mediated autophagy through the AMPK signaling pathway protects INS‑1 cells from human islet amyloid polypeptide‑induced cytotoxicity

(2018) Guanghao Xia et al.   Molecular Medicine Reports

Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

(2018) Atsushi Miki et al.   PLoS One

Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy

(2018) Joselyn Rojas et al.   Journal of Diabetes Research

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Hydroxysafflor yellow A attenuates high glucose-induced pancreatic β-cells oxidative damage via inhibiting JNK/c-jun signaling pathway

(2018) Ying Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity

(2018) Zonghong Li et al.   MOLECULAR & CELLULAR PROTEOMICS

Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy

(2017) Amelia K. Linnemann et al.   FASEB JOURNAL

mTORC in β cells: more Than Only Recognizing Comestibles

(2017) Kathrin Maedler et al.   JOURNAL OF CELL BIOLOGY

mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress

(2017) Gia Cac Chau et al.   JOURNAL OF CELL BIOLOGY

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion

(2017) Nadejda Bozadjieva et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic β-cell death through modulation of autophagy via AMPK/mTOR signaling pathway

(2017) Ritu Varshney et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Oxidative Stress in Pancreatic Beta Cell Regeneration

(2017) Jingjing Wang et al.   Oxidative Medicine and Cellular Longevity

Involvement of receptor-interacting protein 140 in palmitate-stimulated macrophage infiltration of pancreatic beta cells

(2017) Runmei Zou et al.   Experimental and Therapeutic Medicine

Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes

(2017) Lingling Chen et al.   Oncotarget

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

(2017) Miriam Cnop et al.   Molecular Metabolism

Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects with Prediabetes and Type 2 Diabetes Mellitus

(2017) Shipra Bhansali et al.   Frontiers in Endocrinology

Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism

(2017) Kirsten Roomp et al.   PLoS One

The endoplasmic reticulum stress/autophagy pathway is involved in cholesterol-induced pancreatic β-cell injury

(2017) Fei-Juan Kong et al.   Scientific Reports

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

(2016) Arash Yavari et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells

(2016) Jing Wang et al.   CELLULAR SIGNALLING

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+Stores

(2016) Alice Marmugi et al.   DIABETES

Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines

(2016) Ewa Gurgul-Convey et al.   DIABETOLOGIA

Mitochondrial network regulation and its potential interference with inflammatory signals in pancreatic beta cells

(2016) Simone Baltrusch   DIABETOLOGIA

Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes

(2016) Ting Yuan et al.   DIABETOLOGIA

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets

(2016) Chunhua Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes

(2016) Suchitra Kumari Panigrahy et al.   JOURNAL OF DRUG TARGETING

Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL

(2016) Valérie Plaisance et al.   PLoS One

miR-184Regulates Pancreatic β-Cell Function According to Glucose Metabolism

(2015) Sudhir G. Tattikota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How the Location of Superoxide Generation Influences the β-Cell Response to Nitric Oxide

(2015) Katarzyna A. Broniowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes

(2015) Sumaira Z Hasnain et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes☆

(2015) Jinhong Sun et al.   MOLECULAR ASPECTS OF MEDICINE

Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors

(2015) Paola Llanos et al.   PLoS One

Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?

(2015) Nicolai M. Doliba et al.   Molecular Metabolism

The Effect of Nrf2 Pathway Activation on Human Pancreatic Islet Cells

(2015) Yuichi Masuda et al.   PLoS One

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

Pancreatic  -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

(2014) A. Bartolome et al.   DIABETES

LKB1 and AMPK differentially regulate pancreatic β-cell identity

(2014) Marina Kone et al.   FASEB JOURNAL

Increased Glucose Metabolism and Glycerolipid Formation by Fatty Acids and GPR40 Receptor Signaling Underlies the Fatty Acid Potentiation of Insulin Secretion

(2014) Mahmoud El-Azzouny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity

(2014) Michael Rouse et al.   JOURNAL OF ENDOCRINOLOGY

Chlorella Protects Against Hydrogen Peroxide-Induced Pancreatic β-Cell Damage

(2014) Chia-Yu Lin et al.   JOURNAL OF MEDICINAL FOOD

Matrix Metalloproteinase 2 Contributes to Pancreatic Beta Cell Injury Induced by Oxidative Stress

(2014) Chongxiao Liu et al.   PLoS One

Mitochondrial Dysfunction Indirectly Elevates ROS Production by the Endoplasmic Reticulum

(2013) Michael P. Murphy   Cell Metabolism

In Vivo JNK Activation in Pancreatic  -Cells Leads to Glucose Intolerance Caused by Insulin Resistance in Pancreas

(2013) J. Lanuza-Masdeu et al.   DIABETES

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

Pdx-1 Activates Islet  - and  -Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2

(2013) H. L. Hayes et al.   MOLECULAR AND CELLULAR BIOLOGY

Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

(2013) Yongneng Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

(2013) Hyo-Sup Kim et al.   PLoS One

Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

(2013) Nidhi Rohatgi et al.   PLoS One

Chronic high glucose-induced INS-1β cell mitochondrial dysfunction: a comparative mitochondrial proteome with SILAC

(2013) Xiulan Chen et al.   PROTEOMICS

Palmitate induces reactive oxygen species production and β-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling

(2013) Yuichi Sato et al.   Journal of Diabetes Investigation

Endoplasmic Reticulum Stress, Pancreatic  -Cell Degeneration, and Diabetes

(2013) F. R. Papa   Cold Spring Harbor Perspectives in Medicine

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

mTORC1 signaling and regulation of pancreatic β-cell mass

(2012) Manuel Blandino-Rosano et al.   CELL CYCLE

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Curcumin Extract for Prevention of Type 2 Diabetes

(2012) S. Chuengsamarn et al.   DIABETES CARE

Modulation of Apoptosis Pathways by Oxidative Stress and Autophagy in β Cells

(2012) Maorong Wang et al.   Experimental Diabetes Research

NADPH oxidase 2 plays a critical role in dysfunction and apoptosis of pancreatic β-cells induced by very low-density lipoprotein

(2012) Juan Jiao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Endoplasmic Reticulum Stress in theβ-Cell Pathogenesis of Type 2 Diabetes

(2011) Sung Hoon Back et al.   Experimental Diabetes Research

Mitochondrial signals drive insulin secretion in the pancreatic β-cell

(2011) Andreas Wiederkehr et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells

(2010) R. J. Kaufman et al.   DIABETES OBESITY & METABOLISM

Protection of Pancreatic β-Cells by Group VIA Phospholipase A2-Mediated Repair of Mitochondrial Membrane Peroxidation

(2010) Zhengshan Zhao et al.   ENDOCRINOLOGY

Exendin-4 Protects Oxidative Stress-Induced β-Cell Apoptosis through Reduced JNK and GSK3β Activity

(2010) Ju-Young Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways

(2010) Huiping Yuan et al.   PLoS One

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid-Induced ER Stress-Mediated  -Cell Death

(2009) J. Chen et al.   DIABETES

Mitochondrial Networking Protects  -Cells From Nutrient-Induced Apoptosis

(2009) A. J.A. Molina et al.   DIABETES

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Induction of Antioxidant Enzymes by Curcumin and Its Analogues in Human Islets

(2009) A.N. Balamurugan et al.   PANCREAS

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1

(2009) Etti Bachar et al.   PLoS One

Glucose and leptin induce apoptosis in human β-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

(2008) Kathrin Maedler et al.   FASEB JOURNAL

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Carboxypeptidase E mediates palmitate-induced  -cell ER stress and apoptosis

(2008) K. D. Jeffrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulforaphane protects against cytokine- and streptozotocin-induced β-cell damage by suppressing the NF-κB pathway

(2008) Mi-Young Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY