PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

The relationship between GPR40 and lipotoxicity of the pancreatic β-cells as well as the effect of pioglitazone

(2010) Peiwen Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice

(2010) J. K. Kruit et al.   DIABETOLOGIA

Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor

(2009) Delphine Gras et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhibition of human insulin gene transcription by peroxisome proliferator-activated receptor γ and thiazolidinedione oral antidiabetic drugs

(2009) S Schinner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Overexpression of GPR40 in Pancreatic  -Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

(2009) K. Nagasumi et al.   DIABETES

Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the KATP channel and insulin secretion in rats

(2009) T.-J. Chang et al.   DIABETOLOGIA

Peroxisome Proliferator-Activated Receptor   Activation Restores Islet Function in Diabetic Mice through Reduction of Endoplasmic Reticulum Stress and Maintenance of Euchromatin Structure

(2009) C. Evans-Molina et al.   MOLECULAR AND CELLULAR BIOLOGY

Rosiglitazone stimulates the release and synthesis of insulin by enhancing GLUT-2, glucokinase and BETA2/NeuroD expression

(2008) Hyo-Sup Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet-Induced Metabolic Disease

(2008) H. Lan et al.   DIABETES

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

(2008) S. Edfalk et al.   DIABETES

In Vivoandin VitroStudies of a Functional Peroxisome Proliferator-activated Receptor γ Response Element in the Mousepdx-1Promoter

(2008) Dhananjay Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss-of-Function Mutation of theGPR40Gene Associates with Abnormal Stimulated Insulin Secretion by Acting on Intracellular Calcium Mobilization

(2008) Roberto Vettor et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway

(2008) Yu-Feng Zhao et al.   JOURNAL OF ENDOCRINOLOGY