Article
Plant Sciences
Wenqi Jin, Meiling Fan, Yuxin Zhang, Qi Zhang, Chenxu Jing, Rui Jiang, Chunli Piao, Liwei Sun
Summary: This study demonstrates that polydatin (PD) protects beta-cells from lipotoxicity-induced dysfunction and apoptosis by inhibiting endoplasmic reticulum stress (ERS) and preventing excessive autophagy. PD treatment enhances insulin secretion and expression of diabetes-associated genes, promoting beta-cell function. In diabetic mice, PD reduces body weight gain, improves dyslipidemia, enhances beta-cell function, and reduces insulin resistance.
Article
Cell Biology
Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao
Summary: This study reveals squalene epoxidase (SQLE) as a novel oncogene that promotes pancreatic cancer (PC) growth by mitigating endoplasmic reticulum stress and activating lipid raft-regulated Src/PI3K/Akt signaling pathway. SQLE facilitates cell proliferation, induces cell cycle progression, and inhibits apoptosis in vitro, while promoting tumor growth in vivo. SQLE inhibitors effectively suppress PC cell proliferation and xenograft tumor growth, highlighting the potential of SQLE as a therapeutic target for PC.
CELL DEATH & DISEASE
(2023)
Article
Environmental Sciences
Weiqi Liang, Lingling Fu, Mei Feng, Xiaorong Wang, Zhaohui Yun, Jin Xu
Summary: This study used proteomic technology to investigate the effects of tributyltin (TBT) on HL7702 normal human liver cells. The results showed that low dose TBT induced unfolded protein response and endoplasmic reticulum stress, while high dose TBT activated autophagy and eventually led to apoptosis. These findings reveal novel pathways of TBT-induced hepatotoxicity.
Article
Environmental Sciences
Yu Wang, Hongjing Zhao, Mengyao Mu, Menghao Guo, Mingwei Xing
Summary: Arsenic accumulation in the spleen due to environmental exposure can cause severe injuries, while zinc treatment may offer protection against arsenic-induced splenic toxicity in common carp.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Xiaowei He, Dan Wu, Yanan Xu, Yaqin Zhang, Yue Sun, Xiaoai Chang, Yunxia Zhu, Wei Tang
Summary: This study found that PFOA leads to damage and apoptosis of pancreatic beta cells, resulting in reduced insulin secretion. The increased expression of ER stress-related genes, particularly Trib3, contributes to this process. Inhibiting Trib3 expression can protect beta cells from PFOA-induced damage and apoptosis by alleviating ER stress.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
Summary: Brief Summary: The study demonstrates that pioglitazone selectively protects beta cells against high glucose-induced dysfunction by activating the AMPK and GLS1 axis, resulting in elevated GSH/GSSG ratio and inhibition of mitochondrial dysfunction.
Article
Environmental Sciences
Lin Zhao, Liyuan Wang, Han Wang, Tao Xi, Sijia Liu, Yang Li, Jianping Ruan, Yongqing Huang
Summary: Fluoride-induced endoplasmic reticulum (ER) stress is responsible for enamel mineralization disorder. This study investigated the mechanisms of fluoride-induced ER stress and autophagy in ameloblasts, and the regulatory role of ER molecular chaperone GRP78 in fluoride-induced autophagy.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Endocrinology & Metabolism
Decio L. Eizirik, Florian Szymczak, Maria Ines Alvelos, Frank Martin
Summary: This article discusses the importance of focusing on beta-cells in type 1 diabetes, proposing the design of therapies by defining regulatory networks rather than solely targeting the immune system.
Article
Biochemistry & Molecular Biology
Lu Wang, Rundong Song, Minghai Ma, Yuhang Chen, Yunzhong Jiang, Jianpeng Li, Zezhong Yang, Lu Zhang, Minxuan Jing, Xinyang Wang, Mengzhao Zhang, Jinhai Fan
Summary: The study reveals that SC66 exerts its anticancer effects in bladder cancer by inhibiting cell proliferation and inducing apoptosis, while inhibiting autophagy can enhance the cytotoxic effects of SC66. It is also the first report on the AKT-independent anticancer mechanism of SC66 in bladder cancer, mediated by the endoplasmic reticulum stress pathway. These findings suggest that SC66 has potential as a novel therapeutic agent for bladder cancer.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Jingru Guo, Junshu Nie, Zhuo Chen, Xian Wang, Huijie Hu, Jing Xu, Jingjing Lu, Li Ma, Hong Ji, Jianbin Yuan, Bin Xu
Summary: Cold exposure induces liver damage, endoplasmic reticulum stress, and autophagy through the SIRT2/FoxO1 pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Li Wu, Yuncheng Lv, Ying Lv, Sunmin Xiang, Zhibo Zhao, Ziqing Tang, Linling Ou, Bin Yan, Xinhua Xiao, Gebo Wen, Renxian Cao, Jing Yang
Summary: Excessive cholesterol accumulation in pancreatic beta cells can lead to ER stress and apoptosis, and the decrease in SCGN expression may exacerbate this process.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Cell Biology
Yingjuan Liu, Xiaolin Wu, Yue Wang, Yunliang Guo
Summary: This study found that mature adipocytes can directly activate hepatic stellate cells, promoting liver fibrosis progression, and providing an in vitro model for drug screening for liver diseases.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Abhishek Kulkarni, Charanya Muralidharan, Sarah C. May, Sarah A. Tersey, Raghavendra G. Mirmira
Summary: The pathogenesis of diabetes varies between type 1 and type 2, but dysfunction and death of insulin-producing beta-cells are common to all forms of diabetes. Recent studies have advanced our understanding of the molecular pathways that contribute to beta-cell demise, including endoplasmic reticulum stress, integrated stress response, oxidative stress, and impaired autophagy. Animal models have been instrumental in identifying genes and proteins involved in beta-cell dysfunction during diabetes.
Article
Cell Biology
Yanming Yu, Daoxu Wu, Yongwei Li, Hui Qiao, Zhengfei Shan
Summary: Ketamine-induced cystitis results in bladder hyperactivity and injury by activating autophagy, apoptosis, and endoplasmic reticulum stress-related markers. Salubrinal can reverse the effects of ketamine on complex formation and related markers. Transfection with shIRE1 can offset the effects of ketamine on cells.
Article
Biochemistry & Molecular Biology
Mahamud-ur Rashid, Shahrokh Lorzadeh, Ang Gao, Saeid Ghavami, Kevin M. Coombs
Summary: This study reveals that the loss of PSMA2 gene leads to changes in cellular proteome, affecting cell survival, development, and the occurrence of diseases like cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)