Mechanism of gating and partial agonist action in the glycine receptor

Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs

(2020) Arvind Kumar et al.   Nature Communications

A single molecular distance predicts agonist binding energy in nicotinic receptors

(2019) Sushree Tripathy et al.   JOURNAL OF GENERAL PHYSIOLOGY

Author Correction: GABAA receptor signalling mechanisms revealed by structural pharmacology

(2019) Simonas Masiulis et al.   NATURE

Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment

(2019) Henriette E Autzen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

(2019) Anant Gharpure et al.   NEURON

Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel

(2018) Nuriya Mukhtasimova et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cryo-EM structure of 5-HT3A receptor in its resting conformation

(2018) Sandip Basak et al.   Nature Communications

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Structural principles of distinct assemblies of the human α4β2 nicotinic receptor

(2018) Richard M. Walsh et al.   NATURE

An Ion-Permeable State of the Glycine Receptor Captured by Molecular Dynamics

(2018) Adrien Henri Cerdan et al.   STRUCTURE

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

(2018) Swastik Phulera et al.   eLife

Conformational transitions of the serotonin 5-HT3 receptor

(2018) Lucie Polovinkin et al.   NATURE

Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer

(2018) Duncan Laverty et al.   NATURE

Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification

(2018) Cheng Zhang et al.   ULTRAMICROSCOPY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Chasing the open-state structure of pentameric ligand-gated ion channels

(2017) Giovanni Gonzalez-Gutierrez et al.   JOURNAL OF GENERAL PHYSIOLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Crystal Structures of Human GlyRα3 Bound to Ivermectin

(2017) Xin Huang et al.   STRUCTURE

Model-based local density sharpening of cryo-EM maps

(2017) Arjen J Jakobi et al.   eLife

The GlyR Extracellular β8–β9 Loop – A Functional Determinant of Agonist Potency

(2017) Dieter Janzen et al.   Frontiers in Molecular Neuroscience

Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR

(2016) Nuriya Mukhtasimova et al.   JOURNAL OF GENERAL PHYSIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels

(2016) Andrew J R Plested   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

(2016) Xin Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nanodiscs for structural and functional studies of membrane proteins

(2016) Ilia G Denisov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels

(2016) Andrew J R Plested   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

(2016) Xin Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nanodiscs for structural and functional studies of membrane proteins

(2016) Ilia G Denisov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nicotinic acetylcholine receptor–lipid interactions: Mechanistic insight and biological function

(2015) John E. Baenziger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The styrene–maleic acid copolymer: a versatile tool in membrane research

(2015) Jonas M. Dörr et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

(2015) Xin Huang et al.   NATURE

Glycine receptor mechanism elucidated by electron cryo-microscopy

(2015) Juan Du et al.   NATURE

The desensitization gate of inhibitory Cys-loop receptors

(2015) Marc Gielen et al.   Nature Communications

Surfactant-free purification of membrane proteins with intact native membrane environment

(2015) Mohammed Jamshad et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Unraveling Mechanisms Underlying Partial Agonism in 5-HT3A Receptors

(2014) J. Corradi et al.   JOURNAL OF NEUROSCIENCE

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

(2014) Thorsten Althoff et al.   NATURE

The Structural Mechanism of the Cys-Loop Receptor Desensitization

(2013) Jianliang Zhang et al.   MOLECULAR NEUROBIOLOGY

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Allostery and the Monod-Wyman-Changeux Model After 50 Years

(2012) Jean-Pierre Changeux   Annual Review of Biophysics

Sanjeevini: a freely accessible web-server for target directed lead molecule discovery

(2012) B Jayaram et al.   BMC BIOINFORMATICS

An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors

(2012) Snehal Jadey et al.   JOURNAL OF GENERAL PHYSIOLOGY

The  1K276E Startle Disease Mutation Reveals Multiple Intermediate States in the Gating of Glycine Receptors

(2012) R. Lape et al.   JOURNAL OF NEUROSCIENCE

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Functional Reconstitution of an ABC Transporter in Nanodiscs for Use in Electron Paramagnetic Resonance Spectroscopy

(2010) Frances Joan D. Alvarez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Single-Channel Kinetic Analysis for Activation and Desensitization of Homomeric 5-HT3A Receptors

(2009) Jeremías Corradi et al.   BIOPHYSICAL JOURNAL

DoG Picker and TiltPicker: Software tools to facilitate particle selection in single particle electron microscopy

(2009) N.R. Voss et al.   JOURNAL OF STRUCTURAL BIOLOGY

Membrane Proteins Solubilized Intact in Lipid Containing Nanoparticles Bounded by Styrene Maleic Acid Copolymer

(2009) Timothy J. Knowles et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection and trapping of intermediate states priming nicotinic receptor channel opening

(2009) Nuriya Mukhtasimova et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

On the nature of partial agonism in the nicotinic receptor superfamily

(2008) Remigijus Lape et al.   NATURE

Glycinergic Transmission Shaped by the Corelease of GABA in a Mammalian Auditory Synapse

(2008) Tao Lu et al.   NEURON