Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

(2015) Xin Huang et al.   NATURE

Glycine receptor mechanism elucidated by electron cryo-microscopy

(2015) Juan Du et al.   NATURE

Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch

(2015) Edmund Foster et al.   NEURON

The desensitization gate of inhibitory Cys-loop receptors

(2015) Marc Gielen et al.   Nature Communications

Selective potentiation of alpha 1 glycine receptors by ginkgolic acid

(2015) Galyna Maleeva et al.   Frontiers in Molecular Neuroscience

Agonist and Antagonist Binding in Human Glycine Receptors

(2014) Rilei Yu et al.   BIOCHEMISTRY

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

X-ray structure of the mouse serotonin 5-HT3 receptor

(2014) Ghérici Hassaine et al.   NATURE

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

(2014) Thorsten Althoff et al.   NATURE

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

(2012) Wei Xiong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic Pain States: Pharmacological Strategies to Restore Diminished Inhibitory Spinal Pain Control

(2011) Hanns Ulrich Zeilhofer et al.   Annual Review of Pharmacology and Toxicology

Allosteric modulation of glycine receptors

(2011) Gonzalo E. Yevenes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia

(2011) Wei Xiong et al.   Nature Chemical Biology

Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update

(2010) Robert H. Dworkin et al.   MAYO CLINIC PROCEEDINGS

Central mechanisms of pathological pain

(2010) Rohini Kuner   NATURE MEDICINE

Prediction of Vss from In Vitro Tissue-Binding Studies

(2009) L. M. Berry et al.   DRUG METABOLISM AND DISPOSITION

Models and Mechanisms of Hyperalgesia and Allodynia

(2009) Jürgen Sandkühler   PHYSIOLOGICAL REVIEWS