Allostery and the Monod-Wyman-Changeux Model After 50 Years

Hemoglobin allostery: Variations on the theme

(2011) Andrea Bellelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Thrombin plasticity

(2011) James A. Huntington   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Microsecond Simulations Indicate that Ethanol Binds between Subunits and Could Stabilize an Open-State Model of a Glycine Receptor

(2011) Samuel Murail et al.   BIOPHYSICAL JOURNAL

Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels

(2011) Stuart A. Forman et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Polyphosphates and Pyrophosphates of Pentopyranoses and Pentofuranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release

(2011) Konstantina C. Fylaktakidou et al.   ChemMedChem

The oligomeric state sets GABABreceptor signalling efficacy

(2011) Laëtitia Comps-Agrar et al.   EMBO JOURNAL

Additional Acetylcholine (ACh) Binding Site at α4/α4 Interface of (α4β2)2α4 Nicotinic Receptor Influences Agonist Sensitivity

(2011) Simone Mazzaferro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G Protein Activation by Serotonin Type 4 Receptor Dimers

(2011) Lucie P. Pellissier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The long activations of α2 glycine channels can be described by a mechanism with reaction intermediates (“flip”)

(2011) Paraskevi Krashia et al.   JOURNAL OF GENERAL PHYSIOLOGY

A Tale of Two Repressors

(2011) Mitchell Lewis   JOURNAL OF MOLECULAR BIOLOGY

Thinking in cycles: MWC is a good model for acetylcholine receptor-channels

(2011) Anthony Auerbach   JOURNAL OF PHYSIOLOGY-LONDON

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Structure of the human histamine H1 receptor complex with doxepin

(2011) Tatsuro Shimamura et al.   NATURE

The structural basis of agonist-induced activation in constitutively active rhodopsin

(2011) Jörg Standfuss et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Structure and function of an irreversible agonist-β2 adrenoceptor complex

(2011) Daniel M. Rosenbaum et al.   NATURE

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings

(2011) Natacha Rochel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dimers and beyond: The functional puzzles of class C GPCRs

(2011) Julie Kniazeff et al.   PHARMACOLOGY & THERAPEUTICS

Unsuspected pathway of the allosteric transition in hemoglobin

(2011) S. Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

(2011) R. J. Howard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

50th anniversary of the word “allosteric”

(2011) Jean-Pierre Changeux   PROTEIN SCIENCE

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

(2011) Angela J. Boettcher et al.   STRUCTURE

Allostery in trypsin-like proteases suggests new therapeutic strategies

(2011) David W. Gohara et al.   TRENDS IN BIOTECHNOLOGY

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC

(2011) Iwan Zimmermann et al.   PLOS BIOLOGY

Allosteric Receptors: From Electric Organ to Cognition

(2010) Jean-Pierre Changeux   Annual Review of Pharmacology and Toxicology

Ribonucleotide reductases: Substrate specificity by allostery

(2010) Peter Reichard   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Relationships between Structural Dynamics and Functional Kinetics in Oligomeric Membrane Receptors

(2010) Stuart J. Edelstein et al.   BIOPHYSICAL JOURNAL

Ligand-directed signalling at β-adrenoceptors

(2010) Bronwyn A. Evans et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal models for autosomal dominant frontal lobe epilepsy: on the origin of seizures

(2010) Ortrud K Steinlein   Expert Review of Neurotherapeutics

Unveiling the Timescale of the R–T Transition in Human Hemoglobin

(2010) M. Cammarata et al.   JOURNAL OF MOLECULAR BIOLOGY

Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography

(2010) James E. Voss et al.   NATURE

Structural mechanism of C-type inactivation in K+ channels

(2010) Luis G. Cuello et al.   NATURE

Structural basis for the coupling between activation and inactivation gates in K+ channels

(2010) Luis G. Cuello et al.   NATURE

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

(2010) Ricarda J C Hilf et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transmembrane signaling by GPCRs: Insight from rhodopsin and opsin structures

(2010) Hui-Woog Choe et al.   NEUROPHARMACOLOGY

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

(2010) Peter Keov et al.   NEUROPHARMACOLOGY

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function

(2010) Xavier Deupi et al.   PHYSIOLOGY

Principles of conduction and hydrophobic gating in K+ channels

(2010) M. O. Jensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

(2010) H. Nury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, function and mechanism of the anaphase promoting complex (APC/C)

(2010) David Barford   QUARTERLY REVIEWS OF BIOPHYSICS

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch

(2010) F. Bai et al.   SCIENCE

Spontaneous Quaternary and Tertiary T-R Transitions of Human Hemoglobin in Molecular Dynamics Simulation

(2010) Jochen S. Hub et al.   PLoS Computational Biology

G-protein-coupled receptor oligomers: two or more for what? Lessons from mGlu and GABABreceptors

(2009) J.-P. Pin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

(2009) Eric B. Gonzales et al.   NATURE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

Detection and trapping of intermediate states priming nicotinic receptor channel opening

(2009) Nuriya Mukhtasimova et al.   NATURE

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Conformational selection or induced fit: A flux description of reaction mechanism

(2009) G. G. Hammes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Twisting Motion of Single Molecular KcsA Potassium Channel upon Gating

(2008) Hirofumi Shimizu et al.   CELL

Time Evolution of the Quaternary Structure of Escherichia coli Aspartate Transcarbamoylase upon Reaction with the Natural Substrates and a Slow, Tight-Binding Inhibitor

(2008) Jay M. West et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Crystal structure of squid rhodopsin

(2008) Midori Murakami et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Structural Rearrangements of NR1/NR2A NMDA Receptors during Allosteric Inhibition

(2008) Marc Gielen et al.   NEURON

Allostery and cooperativity revisited

(2008) Qiang Cui et al.   PROTEIN SCIENCE

Protein–protein interaction and quaternary structure

(2008) Joël Janin et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

Cooperative Transition between Open and Closed Conformations in Potassium Channels

(2008) Turkan Haliloglu et al.   PLoS Computational Biology