Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels

Dynamics of the Ligand Binding Domain Layer during AMPA Receptor Activation

(2016) Jelena Baranovic et al.   BIOPHYSICAL JOURNAL

Superactivation of AMPA receptors by auxiliary proteins

(2016) Anna L. Carbone et al.   Nature Communications

Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors

(2016) Maria V. Yelshanskaya et al.   Scientific Reports

The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold

(2015) Giovanni Gonzalez-Gutierrez et al.   JOURNAL OF GENERAL PHYSIOLOGY

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

(2015) Xin Huang et al.   NATURE

Glycine receptor mechanism elucidated by electron cryo-microscopy

(2015) Juan Du et al.   NATURE

Physical basis of apparent pore dilation of ATP-activated P2X receptor channels

(2015) Mufeng Li et al.   NATURE NEUROSCIENCE

Glycine activated ion channel subunits encoded by ctenophore glutamate receptor genes

(2015) Robert Alberstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor

(2015) Radovan Spurny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergence of ion channel genome content in early animal evolution

(2015) Benjamin J. Liebeskind et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The desensitization gate of inhibitory Cys-loop receptors

(2015) Marc Gielen et al.   Nature Communications

Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors

(2015) Corrie J. B. daCosta et al.   Nature Communications

Catch-and-Hold Activation of Muscle Acetylcholine Receptors Having Transmitter Binding Site Mutations

(2014) Prasad Purohit et al.   BIOPHYSICAL JOURNAL

Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States

(2014) Katharina L. Dürr et al.   CELL

Auxiliary proteins promote modal gating of AMPA- and kainate-type glutamate receptors

(2014) Wei Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Lynx1 Shifts α4β2 Nicotinic Receptor Subunit Stoichiometry by Affecting Assembly in the Endoplasmic Reticulum

(2014) Weston A. Nichols et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

X-ray structure of the mouse serotonin 5-HT3 receptor

(2014) Ghérici Hassaine et al.   NATURE

Structural mechanism of glutamate receptor activation and desensitization

(2014) Joel R. Meyerson et al.   NATURE

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

(2014) Thorsten Althoff et al.   NATURE

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Mechanical coupling maintains the fidelity of NMDA receptor–mediated currents

(2014) Rashek Kazi et al.   NATURE NEUROSCIENCE

Structure of an agonist-bound ionotropic glutamate receptor

(2014) M. V. Yelshanskaya et al.   SCIENCE

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism

(2014) L. Chen et al.   SCIENCE

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Radial symmetry in a chimeric glutamate receptor pore

(2014) Timothy J. Wilding et al.   Nature Communications

Loop C and the mechanism of acetylcholine receptor–channel gating

(2013) Prasad Purohit et al.   JOURNAL OF GENERAL PHYSIOLOGY

A propofol binding site on mammalian GABAA receptors identified by photolabeling

(2013) Grace M S Yip et al.   Nature Chemical Biology

Defining the structural relationship between kainate-receptor deactivation and desensitization

(2013) G Brent Dawe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Conformational Intermediate in Glutamate Receptor Activation

(2013) Albert Y. Lau et al.   NEURON

Nanoscale Scaffolding Domains within the Postsynaptic Density Concentrate Synaptic AMPA Receptors

(2013) Harold D. MacGillavry et al.   NEURON

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

(2013) L. Sauguet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional anatomy of an allosteric protein

(2013) Prasad Purohit et al.   Nature Communications

Site-Directed Spin Labeling Reveals Pentameric Ligand-Gated Ion Channel Gating Motions

(2013) Cosma D. Dellisanti et al.   PLOS BIOLOGY

Benzodiazepines Modulate GABAA Receptors by Regulating the Preactivation Step after GABA Binding

(2012) M. C. Gielen et al.   JOURNAL OF NEUROSCIENCE

The  1K276E Startle Disease Mutation Reveals Multiple Intermediate States in the Gating of Glycine Receptors

(2012) R. Lape et al.   JOURNAL OF NEUROSCIENCE

Amino-Terminal Ligands Prolong NMDA Receptor-Mediated EPSCs

(2012) K. R. Tovar et al.   JOURNAL OF NEUROSCIENCE

Coupled Control of Desensitization and Gating by the Ligand Binding Domain of Glutamate Receptors

(2012) Anna L. Carbone et al.   NEURON

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

(2012) R. Spurny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

(2012) Jianjun Pan et al.   Nature Communications

Mechanism of AMPA Receptor Activation by Partial Agonists

(2011) Ahmed H. Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Channel and Structural Foundations of Neuronal  7 Acetylcholine Receptor Potentiation

(2011) C. J. B. daCosta et al.   JOURNAL OF NEUROSCIENCE

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

(2011) Shu-Xing Li et al.   NATURE NEUROSCIENCE

The hidden energetics of ligand binding and activation in a glutamate receptor

(2011) Albert Y Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Specific Sites within the Ligand-Binding Domain and Ion Channel Linkers Modulate NMDA Receptor Gating

(2010) I. Talukder et al.   JOURNAL OF NEUROSCIENCE

Domain organization and function in GluK2 subtype kainate receptors

(2010) U. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variant Ionotropic Glutamate Receptors as Chemosensory Receptors in Drosophila

(2009) Richard Benton et al.   CELL

Number and Locations of Agonist Binding Sites Required to Activate Homomeric Cys-Loop Receptors

(2009) D. Rayes et al.   JOURNAL OF NEUROSCIENCE

Mechanism of differential control of NMDA receptor activity by NR2 subunits

(2009) Marc Gielen et al.   NATURE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

Detection and trapping of intermediate states priming nicotinic receptor channel opening

(2009) Nuriya Mukhtasimova et al.   NATURE

Kinetic basis of partial agonism at NMDA receptors

(2009) Cassandra L Kussius et al.   NATURE NEUROSCIENCE

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

Distinct gating modes determine the biphasic relaxation of NMDA receptor currents

(2008) Wei Zhang et al.   NATURE NEUROSCIENCE

High-resolution structure of the open NaK channel

(2008) Amer Alam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular Basis of Kainate Receptor Modulation by Sodium

(2008) Andrew J.R. Plested et al.   NEURON