Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer

CAVER Analyst 2.0: analysis and visualization of channels and tunnels in protein structures and molecular dynamics trajectories

(2018) Adam Jurcik et al.   BIOINFORMATICS

The GABA A Receptor β Subunit Is Required for Inhibitory Transmission

(2018) Quynh-Anh Nguyen et al.   NEURON

MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps

(2018) Jose Luis Vilas et al.   STRUCTURE

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Structure of a human synaptic GABAA receptor

(2018) Shaotong Zhu et al.   NATURE

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

(2018) Swastik Phulera et al.   eLife

GABAA receptor signalling mechanisms revealed by structural pharmacology

(2018) Simonas Masiulis et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites

(2017) Duncan Laverty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for GABAA receptor potentiation by neurosteroids

(2017) Paul S Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites

(2017) Duncan Laverty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for GABAA receptor potentiation by neurosteroids

(2017) Paul S Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GABA A Receptor Coupling Junction and Pore GABRB3 Mutations are Linked to Early-Onset Epileptic Encephalopathy

(2017) Ciria C. Hernandez et al.   Scientific Reports

Segregation of lipids near acetylcholine-receptor channels imaged by cryo-EM

(2017) Nigel Unwin   IUCrJ

Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes

(2016) Stuart A. Forman et al.   ANESTHESIA AND ANALGESIA

Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy

(2016) J.M. de la Rosa-Trevín et al.   JOURNAL OF STRUCTURAL BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

(2016) Ákos Nemecz et al.   NEURON

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs

(2016) Anahita Javaheri et al.   Nature Microbiology

Phosphoinositides regulate ion channels

(2015) Bertil Hille et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β−Interface

(2015) Selwyn S. Jayakar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1β3γ2LGABAAreceptor account for theirin vivoeffects

(2015) Rooma Desai et al.   JOURNAL OF PHYSIOLOGY-LONDON

The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders

(2015) Sien Braat et al.   NEURON

The desensitization gate of inhibitory Cys-loop receptors

(2015) Marc Gielen et al.   Nature Communications

The Role of Intracellular Linkers in Gating and Desensitization of Human Pentameric Ligand-Gated Ion Channels

(2014) D. Papke et al.   JOURNAL OF NEUROSCIENCE

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

GABRA1 and STXBP1: Novel genetic causes of Dravet syndrome

(2014) G. L. Carvill et al.   NEUROLOGY

Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function

(2014) Steven Mennerick et al.   PSYCHOPHARMACOLOGY

De novo mutations in epileptic encephalopathies

(2013) et al.   NATURE

A propofol binding site on mammalian GABAA receptors identified by photolabeling

(2013) Grace M S Yip et al.   Nature Chemical Biology

Human α1β3γ2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state

(2013) Zuzana Dostalova et al.   PROTEIN SCIENCE

Structure, Function, and Modulation of GABAAReceptors

(2012) Erwin Sigel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gephyrin, the enigmatic organizer at GABAergic synapses

(2012) Verena Tretter et al.   Frontiers in Cellular Neuroscience

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Novel α1 and γ2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy

(2011) Pamela Lachance-Touchette et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A Bayesian View on Cryo-EM Structure Determination

(2011) Sjors H.W. Scheres   JOURNAL OF MOLECULAR BIOLOGY

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mutations in GABAAreceptor subunits associated with genetic epilepsies

(2010) Robert L. Macdonald et al.   JOURNAL OF PHYSIOLOGY-LONDON

High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAAand serotonin receptors

(2010) Zuzana Dostalova et al.   PROTEIN SCIENCE

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY