Vascular smooth muscle cells in atherosclerosis: time for a re-assessment

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis

(2020) Shulan Pi et al.   Autophagy

Polygenic risk scores for coronary artery disease and subsequent event risk amongst established cases

(2020) Laurence J Howe et al.   HUMAN MOLECULAR GENETICS

Extracellular Matrix in Vascular Disease, Part 2/4

(2020) Javier Barallobre-Barreiro et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis

(2020) Gabriel F. Alencar et al.   CIRCULATION

The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification

(2020) Estella Zuccolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human

(2020) Huize Pan et al.   CIRCULATION

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

(2020) Marie AC Depuydt et al.   CIRCULATION RESEARCH

Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis

(2019) Ying Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

(2019) Larissa G.P. Langhi Prata et al.   SEMINARS IN IMMUNOLOGY

TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression

(2019) Quanyi Zhao et al.   Genome Medicine

Smooth Muscle Cell Phenotypic Diversity

(2019) Mingjun Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genetic Insights Into Smooth Muscle Cell Contributions to Coronary Artery Disease

(2019) Doris Wong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Human- and Smooth Muscle Cell-Enriched lncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling

(2019) Amira D Mahmoud et al.   CIRCULATION RESEARCH

Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts

(2019) Jessal J. Patel et al.   EXPERIMENTAL CELL RESEARCH

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

(2019) Robert C. Wirka et al.   NATURE MEDICINE

Vascular smooth muscle cells in atherosclerosis

(2019) Gemma L. Basatemur et al.   Nature Reviews Cardiology

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

(2019) Michela Borghesan et al.   Cell Reports

Coronary Disease-Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway

(2019) Manabu Nagao et al.   CIRCULATION RESEARCH

Emerging roles of extracellular vesicles in cellular senescence and aging

(2018) Masaki Takasugi   AGING CELL

Smooth muscle cell fate and plasticity in atherosclerosis

(2018) Sima Allahverdian et al.   CARDIOVASCULAR RESEARCH

Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis

(2018) Mandy O J Grootaert et al.   CARDIOVASCULAR RESEARCH

New models to study vascular mural cell embryonic origin: implications in vascular diseases

(2018) Sanjay Sinha et al.   CARDIOVASCULAR RESEARCH

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

(2018) Andrew L Durham et al.   CARDIOVASCULAR RESEARCH

Proteomic Architecture of Human Coronary and Aortic Atherosclerosis

(2018) David M. Herrington et al.   CIRCULATION

Vascular Smooth Muscle–Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome

(2018) Magda R. Hamczyk et al.   CIRCULATION

Novel drug discovery strategies for atherosclerosis that target necrosis and necroptosis

(2018) Isabelle Coornaert et al.   Expert Opinion on Drug Discovery

Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

(2018) Ashish Misra et al.   Nature Communications

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci

(2018) Boxiang Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease

(2018) Eithne M. Maguire et al.   VASCULAR PHARMACOLOGY

Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

(2018) Lina Dobnikar et al.   Nature Communications

Metalloproteinases in atherosclerosis

(2017) Jason L. Johnson   EUROPEAN JOURNAL OF PHARMACOLOGY

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques

(2017) Sarah R. Langley et al.   JOURNAL OF CLINICAL INVESTIGATION

Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression

(2017) Michael Wierer et al.   MOLECULAR & CELLULAR PROTEOMICS

Coronary Artery Calcification

(2017) Chris Reutelingsperger et al.   JACC-Cardiovascular Imaging

LncRNA MALAT1 regulates smooth muscle cell phenotype switch via activation of autophagy

(2017) Tie-Feng Song et al.   Oncotarget

Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness Regulators

(2017) Christopher K. Yu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration

(2017) Xuechong Hong et al.   Scientific Reports

PCSK9 knock-out mice are protected from neointimal formation in response to perivascular carotid collar placement

(2016) Nicola Ferri et al.   ATHEROSCLEROSIS

Lineage tracing of cells involved in atherosclerosis

(2016) Julián Albarrán-Juárez et al.   ATHEROSCLEROSIS

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

(2016) Rafael Kramann et al.   Cell Stem Cell

Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4Novelty and Significance

(2016) Mark W. Majesky et al.   CIRCULATION RESEARCH

Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis ModelsNovelty and Significance

(2016) Joel Chappell et al.   CIRCULATION RESEARCH

WNT/β-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression

(2016) Ting Cai et al.   EXPERIMENTAL CELL RESEARCH

Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation

(2016) A. N. Kapustin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective

(2016) Olga A Cherepanova et al.   NATURE MEDICINE

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Global Overview of the Epidemiology of Atherosclerotic Cardiovascular Disease

(2015) Simon Barquera et al.   ARCHIVES OF MEDICAL RESEARCH

Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory

(2015) Delphine Gomez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like PhenotypeSignificance

(2015) Yuliya Vengrenyuk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory PhenotypeSignificance

(2015) Sarah E. Gardner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability

(2015) Martin Bennett et al.   CIRCULATION

Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

(2015) A. N. Kapustin et al.   CIRCULATION RESEARCH

Site-Specific Secretome Map Evidences VSMC-Related Markers of Coronary Atherosclerosis Grade and Extent in the Hypercholesterolemic Swine

(2015) Silvia Rocchiccioli et al.   DISEASE MARKERS

Endothelial-to-mesenchymal transition drives atherosclerosis progression

(2015) Pei-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Statins on Serial Coronary Calcification During Atheroma Progression and Regression

(2015) Rishi Puri et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Pathophysiology of native coronary, vein graft and in-stent atherosclerosis

(2015) Kazuyuki Yahagi et al.   Nature Reviews Cardiology

Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming

(2015) Peter J. Quesenberry et al.   Stem Cell Research & Therapy

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap

(2015) Sylvia T. Nurnberg et al.   PLoS Genetics

miRNA-221 and miRNA-222 synergistically function to promote vascular calcification

(2014) N. C. W. Mackenzie et al.   CELL BIOCHEMISTRY AND FUNCTION

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

(2014) Sima Allahverdian et al.   CIRCULATION

Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis

(2014) Susanne Feil et al.   CIRCULATION RESEARCH

Role of Krüppel-Like Factor 4 and its Binding Proteins in Vascular Disease

(2014) Tadashi Yoshida et al.   Journal of Atherosclerosis and Thrombosis

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Detection of histone modifications at specific gene loci in single cells in histological sections

(2013) Delphine Gomez et al.   NATURE METHODS

Spry1 and Spry4 Differentially Regulate Human Aortic Smooth Muscle Cell Phenotype via Akt/FoxO/Myocardin Signaling

(2013) Xuehui Yang et al.   PLoS One

Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus

(2013) Clint L. Miller et al.   PLoS Genetics

Smooth Muscle–Selective Inhibition of Nuclear Factor‐κB Attenuates Smooth Muscle Phenotypic Switching and Neointima Formation Following Vascular Injury

(2013) Tadashi Yoshida et al.   Journal of the American Heart Association

Smooth Muscle Phenotypic Modulation—A Personal Experience

(2012) Julie H. Campbell et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study

(2012) Veena Naik et al.   CARDIOVASCULAR RESEARCH

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

Cooperative Binding of KLF4, pELK-1, and HDAC2 to a G/C Repressor Element in the SM22α Promoter Mediates Transcriptional Silencing During SMC Phenotypic Switching In Vivo

(2012) Morgan Salmon et al.   CIRCULATION RESEARCH

Krüppel-like Factor 4 Contributes to High Phosphate-induced Phenotypic Switching of Vascular Smooth Muscle Cells into Osteogenic Cells

(2012) Tadashi Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adventitial Pericyte Progenitor/Mesenchymal Stem Cells Participate in the Restenotic Response to Arterial Injury

(2012) Ulrich Tigges et al.   JOURNAL OF VASCULAR RESEARCH

Drugs Targeting Epigenetic Histone Acetylation in Vascular Smooth Muscle Cells for Restenosis and Atherosclerosis

(2011) Rama Natarajan   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Signaling Mechanisms That Regulate Smooth Muscle Cell Differentiation

(2011) Christopher P. Mack   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bone Marrow–Derived Smooth Muscle–Like Cells Are Infrequent in Advanced Primary Atherosclerotic Plaques but Promote Atherosclerosis

(2011) Haixiang Yu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Myofibroblast-Mediated Adventitial Remodeling

(2011) Matteo Coen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate

(2011) Catherine M. Shanahan et al.   CIRCULATION RESEARCH

The Wnt pathways in vascular disease

(2011) Aikaterini Tsaousi et al.   CURRENT OPINION IN LIPIDOLOGY

Intraplaque haemorrhages as the trigger of plaque vulnerability

(2011) J.-B. Michel et al.   EUROPEAN HEART JOURNAL

Adipocyte-Derived Factors Regulate Vascular Smooth Muscle Cells Through Mineralocorticoid and Glucocorticoid Receptors

(2011) Aurelie Nguyen Dinh Cat et al.   HYPERTENSION

Down-regulation of Krüppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-β and Bone Morphogenetic Protein 4

(2011) Brandi N. Davis-Dusenbery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells

(2011) Guangdong Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-Like Factor 4

(2010) Changqing Xie et al.   STEM CELLS AND DEVELOPMENT

Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition

(2009) Ritsuko Nakano-Kurimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle

(2009) Rebecca A. Deaton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Functional Analysis of the Chromosome 9p21.3 Coronary Artery Disease Risk Locus

(2009) Olga Jarinova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Free cholesterol overloading induced smooth muscle cells death and activated both ER- and mitochondrial-dependent death pathway

(2009) Xu Kedi et al.   ATHEROSCLEROSIS

A Necessary Role of miR-221 and miR-222 in Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia

(2009) Xiaojun Liu et al.   CIRCULATION RESEARCH

Vascular Smooth Muscle Cell Apoptosis Induces Interleukin-1–Directed Inflammation

(2009) Murray C.H. Clarke et al.   CIRCULATION RESEARCH

Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster

(2009) Thomas Boettger et al.   JOURNAL OF CLINICAL INVESTIGATION

Complex Regulation and Function of the Inflammatory Smooth Muscle Cell Phenotype in Atherosclerosis

(2009) Anthony Wayne Orr et al.   JOURNAL OF VASCULAR RESEARCH

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

(2009) Kimberly R. Cordes et al.   NATURE

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Statins Use a Novel Nijmegen Breakage Syndrome-1–Dependent Pathway to Accelerate DNA Repair in Vascular Smooth Muscle Cells

(2008) Melli Mahmoudi et al.   CIRCULATION RESEARCH

Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration

(2008) Murray C.H. Clarke et al.   CIRCULATION RESEARCH

Induction of MicroRNA-221 by Platelet-derived Growth Factor Signaling Is Critical for Modulation of Vascular Smooth Muscle Phenotype

(2008) Brandi N. Davis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY