Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human

All-Trans-Retinoic Acid Suppresses Neointimal Hyperplasia and Inhibits Vascular Smooth Muscle Cell Proliferation and Migration via Activation of AMPK Signaling Pathway

(2019) Jingzhi Zhang et al.   Frontiers in Pharmacology

Genetic Insights Into Smooth Muscle Cell Contributions to Coronary Artery Disease

(2019) Doris Wong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Human- and Smooth Muscle Cell-Enriched lncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling

(2019) Amira D Mahmoud et al.   CIRCULATION RESEARCH

Retinoic acid signaling pathways

(2019) Norbert B. Ghyselinck et al.   DEVELOPMENT

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

(2019) Robert C. Wirka et al.   NATURE MEDICINE

Vascular smooth muscle cells in atherosclerosis

(2019) Gemma L. Basatemur et al.   Nature Reviews Cardiology

Single-cell immune landscape of human atherosclerotic plaques

(2019) Dawn M. Fernandez et al.   NATURE MEDICINE

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass CytometryNovelty and Significance

(2018) Holger Winkels et al.   CIRCULATION RESEARCH

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm

(2018) Hongxu Ding et al.   Nature Communications

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

(2018) Lina Dobnikar et al.   Nature Communications

Treatment of Acute Promyelocytic Leukemia in Adults

(2018) Afaf E.G. Osman et al.   Journal of Oncology Practice

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis ModelsNovelty and Significance

(2016) Joel Chappell et al.   CIRCULATION RESEARCH

Functional characterization of somatic mutations in cancer using network-based inference of protein activity

(2016) Mariano J Alvarez et al.   NATURE GENETICS

Retinoic acid induces macrophage cholesterol efflux and inhibits atherosclerotic plaque formation in apoE-deficient mice

(2015) Wenjing Zhou et al.   BRITISH JOURNAL OF NUTRITION

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis

(2014) Susanne Feil et al.   CIRCULATION RESEARCH

Deletion of Yes-Associated Protein (YAP) Specifically in Cardiac and Vascular Smooth Muscle Cells Reveals a Crucial Role for YAP in Mouse Cardiovascular Development

(2014) Yong Wang et al.   CIRCULATION RESEARCH

Identification of novel retinoic acid target genes

(2014) Joanne G.A. Savory et al.   DEVELOPMENTAL BIOLOGY

Genes involved in cell adhesion and signaling: a new repertoire of retinoic acid receptor target genes in mouse embryonic fibroblasts

(2013) Z. Al Tanoury et al.   JOURNAL OF CELL SCIENCE

Smooth Muscle–Selective Inhibition of Nuclear Factor‐κB Attenuates Smooth Muscle Phenotypic Switching and Neointima Formation Following Vascular Injury

(2013) Tadashi Yoshida et al.   Journal of the American Heart Association

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

(2012) Yvonne Döring et al.   CIRCULATION

All-trans-Retinoic Acid Ameliorated High Fat Diet-Induced Atherosclerosis in Rabbits by Inhibiting Platelet Activation and Inflammation

(2012) Birong Zhou et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model

(2010) Chang H. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-Specific Interaction of Retinoic Acid Receptors with Target Genes in Mouse Embryonic Fibroblasts and Embryonic Stem Cells

(2009) L. Delacroix et al.   MOLECULAR AND CELLULAR BIOLOGY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE