Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation

Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like PhenotypeSignificance

(2015) Yuliya Vengrenyuk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

(2015) A. N. Kapustin et al.   CIRCULATION RESEARCH

MicroRNA-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial HypertensionNovelty and Significance

(2015) Lin Deng et al.   CIRCULATION RESEARCH

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development

(2015) Jianhe Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Annexin II-dependent actin remodelling evoked by hydrogen peroxide requires the metalloproteinase/sphingolipid pathway

(2015) Christel Cinq-Frais et al.   Redox Biology

Microvesicles as Cell–Cell Messengers in Cardiovascular Diseases

(2014) Xavier Loyer et al.   CIRCULATION RESEARCH

Small entities with large impact

(2014) Joshua D. Hutcheson et al.   CURRENT OPINION IN LIPIDOLOGY

Bone Morphogenic Protein (BMP) Signaling Up-regulates Neutral Sphingomyelinase 2 to Suppress Chondrocyte Maturation via the Akt Protein Signaling Pathway as a Negative Feedback Mechanism

(2014) Hironori Kakoi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors

(2014) C. M. Wilson et al.   JOURNAL OF CELL SCIENCE

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

(2013) B. W. M. van Balkom et al.   BLOOD

Macrophage-Derived Matrix Vesicles

(2013) Sophie E. P. New et al.   CIRCULATION RESEARCH

Microvesicle-mediated Transfer of MicroRNA-150 from Monocytes to Endothelial Cells Promotes Angiogenesis

(2013) Jing Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

Rare, Nonsynonymous Variant in the Smooth Muscle-Specific Isoform of Myosin Heavy Chain, MYH11 , R247C, Alters Force Generation in the Aorta and Phenotype of Smooth Muscle Cells

(2012) Shao-Qing Kuang et al.   CIRCULATION RESEARCH

Cancer Cells Induced to Express Mesenchymal Phenotype Release Exosome-like Extracellular Vesicles Carrying Tissue Factor

(2012) Delphine Garnier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Protease-Activated Receptor-2 Modulates Protease-Activated Receptor-1–Driven Neointimal Hyperplasia

(2011) Leila M. Sevigny et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SDF-1α Induction in Mature Smooth Muscle Cells by Inactivation of PTEN Is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation

(2011) Raphael A. Nemenoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Upregulation of smpd3 via BMP2 stimulation and Runx2

(2011) Young-Mi Chae et al.   BMB Reports

Thrombin Generation in Hemorrhage Control and Vascular Occlusion

(2011) Kenneth G. Mann   CIRCULATION

Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate

(2011) Catherine M. Shanahan et al.   CIRCULATION RESEARCH

Calcium Regulates Key Components of Vascular Smooth Muscle Cell–Derived Matrix Vesicles to Enhance Mineralization

(2011) Alexander N. Kapustin et al.   CIRCULATION RESEARCH

A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization

(2011) Zohreh Khavandgar et al.   JOURNAL OF CELL BIOLOGY

Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro

(2010) Andrew P. Sage et al.   KIDNEY INTERNATIONAL

Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle

(2009) Rebecca A. Deaton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

(2008) James A. Thomas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calcium Phosphate Crystals Induce Cell Death in Human Vascular Smooth Muscle Cells

(2008) Alexandra E. Ewence et al.   CIRCULATION RESEARCH

Annexin-Mediated Matrix Vesicle Calcification in Vascular Smooth Muscle Cells

(2008) Neal X Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not Matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis

(2008) R. C. Shroff et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE