TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression

Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy

(2019) Shuang Qin et al.   Journal of Hematology & Oncology

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

Association Between a CCL17 Genetic Variant and Risk of Coronary Artery Disease in a Chinese Han Population

(2018) Yicong Ye et al.   CIRCULATION JOURNAL

Multiple biological functions of transcription factor 21 in the development of various cancers

(2018) Xiaodi Jiang et al.   OncoTargets and Therapy

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci

(2018) Boxiang Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing

(2018) Valentina Lo Sardo et al.   CELL

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk

(2018) Dharini Iyer et al.   PLoS Genetics

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection

(2017) Thomas Vierbuchen et al.   MOLECULAR CELL

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

(2017) Derek Klarin et al.   NATURE GENETICS

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

(2017) Joanna M M Howson et al.   NATURE GENETICS

Association analyses based on false discovery rate implicate new loci for coronary artery disease

(2017) Christopher P Nelson et al.   NATURE GENETICS

Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells

(2017) Wen Juan Tu et al.   Scientific Reports

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells

(2017) Juyong Brian Kim et al.   PLoS Genetics

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

(2017) Jingjing Liang et al.   PLoS Genetics

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

Functional Analysis of a Novel Genome-Wide Association Study Signal inSMAD3That Confers Protection From Coronary Artery DiseaseSignificance

(2016) Adam W. Turner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

(2016) Clint L. Miller et al.   Nature Communications

Functional interaction between COL4A1/COL4A2 and SMAD3 risk loci for coronary artery disease

(2015) Adam W. Turner et al.   ATHEROSCLEROSIS

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Genetically Determined Height and Coronary Artery Disease

(2015) Christopher P. Nelson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap

(2015) Sylvia T. Nurnberg et al.   PLoS Genetics

Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci

(2015) Olga Sazonova et al.   PLoS Genetics

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation

(2014) Clint L. Miller et al.   PLoS Genetics

Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study

(2013) Sonali Pechlivanis et al.   BMC Medical Genetics

Tcf21 regulates the specification and maturation of proepicardial cells

(2013) P. Tandon et al.   DEVELOPMENT

Effect of natural genetic variation on enhancer selection and function

(2013) S. Heinz et al.   NATURE

Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus

(2013) Clint L. Miller et al.   PLoS Genetics

Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks

(2013) Lesca M. Holdt et al.   PLoS Genetics

The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors

(2012) A. Acharya et al.   DEVELOPMENT

Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart

(2012) Caitlin M. Braitsch et al.   DEVELOPMENTAL BIOLOGY

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

(2012) Xiangfeng Lu et al.   NATURE GENETICS

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Network for Activation of Human Endothelial Cells by Oxidized Phospholipids

(2011) Casey E. Romanoski et al.   CIRCULATION RESEARCH

Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding

(2011) Simon C. Biddie et al.   MOLECULAR CELL

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

c-Jun, at the crossroad of the signaling network

(2011) Qinghang Meng et al.   Protein & Cell

Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice

(2010) Axel Visel et al.   NATURE

Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression

(2010) Michael S. Cunnington et al.   PLoS Genetics

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

(2008) Wenqiang Yu et al.   NATURE