Coronary Disease-Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway

TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression

(2019) Quanyi Zhao et al.   Genome Medicine

CRISPR-Cas9 Mediated Epitope Tagging Provides Accurate and Versatile Assessment of Myocardin

(2018) Qing Lyu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

(2018) Ashish Misra et al.   Nature Communications

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci

(2018) Boxiang Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

(2018) Vivek Nanda et al.   PLoS Genetics

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk

(2018) Dharini Iyer et al.   PLoS Genetics

Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

(2017) Derek Klarin et al.   NATURE GENETICS

Association analyses based on false discovery rate implicate new loci for coronary artery disease

(2017) Christopher P Nelson et al.   NATURE GENETICS

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells

(2017) Juyong Brian Kim et al.   PLoS Genetics

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

The transition of smooth muscle cells from a contractile to a migratory, phagocytic phenotype: direct demonstration of phenotypic modulation

(2016) Mairi E. Sandison et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective

(2016) Olga A Cherepanova et al.   NATURE MEDICINE

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

(2016) Clint L. Miller et al.   Nature Communications

Myocardin Regulates Vascular Smooth Muscle Cell Inflammatory Activation and DiseaseSignificance

(2015) Matthew Ackers-Johnson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap

(2015) Sylvia T. Nurnberg et al.   PLoS Genetics

Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci

(2015) Olga Sazonova et al.   PLoS Genetics

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

(2014) Yoko Kojima et al.   JOURNAL OF CLINICAL INVESTIGATION

Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation

(2014) Clint L. Miller et al.   PLoS Genetics

Tcf21 regulates the specification and maturation of proepicardial cells

(2013) P. Tandon et al.   DEVELOPMENT

The Transcription Factor TEAD1 Represses Smooth Muscle-specific Gene Expression by Abolishing Myocardin Function

(2013) Fang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus

(2013) Clint L. Miller et al.   PLoS Genetics

The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors

(2012) A. Acharya et al.   DEVELOPMENT

Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart

(2012) Caitlin M. Braitsch et al.   DEVELOPMENTAL BIOLOGY

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

(2012) Xiangfeng Lu et al.   NATURE GENETICS

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Smooth Muscle Calponin

(2011) Xiaochun Long et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY