Genetic Insights Into Smooth Muscle Cell Contributions to Coronary Artery Disease

Advances in Transcriptomics

(2018) Robert C. Wirka et al.   CIRCULATION RESEARCH

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine AtherosclerosisNovelty and Significance

(2018) Clément Cochain et al.   CIRCULATION RESEARCH

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass CytometryNovelty and Significance

(2018) Holger Winkels et al.   CIRCULATION RESEARCH

Genetics of coronary artery disease in the light of genome-wide association studies

(2018) Heribert Schunkert et al.   Clinical Research in Cardiology

An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm

(2018) Christian L. Lino Cardenas et al.   Nature Communications

The CRISPR tool kit for genome editing and beyond

(2018) Mazhar Adli   Nature Communications

Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets

(2018) Harri Lempiäinen et al.   Scientific Reports

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci

(2018) Boxiang Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility

(2018) Darren A. Cusanovich et al.   CELL

Acting on non-communicable diseases in low- and middle-income tropical countries

(2018) Majid Ezzati et al.   NATURE

Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

(2018) Chen Yao et al.   Nature Communications

Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing

(2018) Valentina Lo Sardo et al.   CELL

Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics

(2018) Matthew D. Krause et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

(2018) Nora Franceschini et al.   Nature Communications

Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement

(2018) Guangshuai Jia et al.   Nature Communications

Identification of 55,000 Replicated DNA Methylation QTL

(2018) Allan F. McRae et al.   Scientific Reports

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

(2018) Vivek Nanda et al.   PLoS Genetics

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk

(2018) Dharini Iyer et al.   PLoS Genetics

Atherosclerotic plaque vulnerability in the statin era

(2017) Jan Nilsson   EUROPEAN HEART JOURNAL

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion

(2017) Zenpei Shimatani et al.   NATURE BIOTECHNOLOGY

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

(2017) Joanna M M Howson et al.   NATURE GENETICS

Association analyses based on false discovery rate implicate new loci for coronary artery disease

(2017) Christopher P Nelson et al.   NATURE GENETICS

Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

(2017) Maxwell R Mumbach et al.   NATURE GENETICS

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

(2017) Julia Joung et al.   Nature Protocols

Genetics of coronary artery disease: discovery, biology and clinical translation

(2017) Amit V. Khera et al.   NATURE REVIEWS GENETICS

Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice

(2017) Danny Halim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

(2017) Sarah Kim-Hellmuth et al.   Nature Communications

Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells

(2017) Nicholas T Hogan et al.   eLife

CRISPR-Cas9 Genome Editing for Treatment of Atherogenic Dyslipidemia

(2017) Alexandra C. Chadwick et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation ofLMOD1, SYNPO2, PDLIM7, PLN, andSYNMHighlights

(2016) Ljubica Perisic Matic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Functional Analysis of a Novel Genome-Wide Association Study Signal inSMAD3That Confers Protection From Coronary Artery DiseaseSignificance

(2016) Adam W. Turner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease LociSignificance

(2016) Yuqi Zhao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genetics links between transforming growth factor β pathway and coronary disease

(2016) Lingyao Zeng et al.   ATHEROSCLEROSIS

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

(2016) Biola M. Javierre et al.   CELL

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis ModelsNovelty and Significance

(2016) Joel Chappell et al.   CIRCULATION RESEARCH

Genetics of Coronary Artery Disease

(2016) Ruth McPherson et al.   CIRCULATION RESEARCH

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

HiChIP: efficient and sensitive analysis of protein-directed genome architecture

(2016) Maxwell R Mumbach et al.   NATURE METHODS

Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation

(2016) Yingchi Zhang et al.   NUCLEIC ACIDS RESEARCH

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases

(2016) O. Franzen et al.   SCIENCE

RNA splicing is a primary link between genetic variation and disease

(2016) Yang I. Li et al.   SCIENCE

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

(2016) Lesca M. Holdt et al.   Nature Communications

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

(2016) Clint L. Miller et al.   Nature Communications

Which Genetics Variants in DNase-Seq Footprints Are More Likely to Alter Binding?

(2016) Gregory A. Moyerbrailean et al.   PLoS Genetics

Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction

(2016) Wei Yang et al.   PLoS Genetics

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease

(2016) Husain A. Talukdar et al.   Cell Systems

Prediction of Causal Candidate Genes in Coronary Artery Disease LociSignificance

(2015) Ingrid Brænne et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery DiseaseSignificance

(2015) Sujoy Ghosh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: The Athero-Express Genomics Study

(2015) Sander W. van der Laan et al.   ATHEROSCLEROSIS

Functional interaction between COL4A1/COL4A2 and SMAD3 risk loci for coronary artery disease

(2015) Adam W. Turner et al.   ATHEROSCLEROSIS

Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application

(2015) Biraja C. Dash et al.   BIOCHEMICAL JOURNAL

Knockout ofAdamts7, a Novel Coronary Artery Disease Locus in Humans, Reduces Atherosclerosis in MiceCLINICAL PERSPECTIVE

(2015) Robert C. Bauer et al.   CIRCULATION

Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic ForcesNovelty and Significance

(2015) Congqing Wu et al.   CIRCULATION RESEARCH

CDKN2B Regulates TGF β Signaling and Smooth Muscle Cell Investment of Hypoxic NeovesselsNovelty and Significance

(2015) Vivek Nanda et al.   CIRCULATION RESEARCH

Expression Quantitative Trait Loci Acting Across Multiple Tissues Are Enriched in Inherited Risk for Coronary Artery DiseaseCLINICAL PERSPECTIVE

(2015) Hassan Foroughi Asl et al.   Circulation-Cardiovascular Genetics

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

(2015) Isaac B Hilton et al.   NATURE BIOTECHNOLOGY

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Fine-mapping cellular QTLs with RASQUAL and ATAC-seq

(2015) Natsuhiko Kumasaka et al.   NATURE GENETICS

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

WASP: allele-specific software for robust molecular quantitative trait locus discovery

(2015) Bryce van de Geijn et al.   NATURE METHODS

The role of regulatory variation in complex traits and disease

(2015) Frank W. Albert et al.   NATURE REVIEWS GENETICS

Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?

(2015) Sarah Anissa Hannou et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap

(2015) Sylvia T. Nurnberg et al.   PLoS Genetics

Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci

(2015) Olga Sazonova et al.   PLoS Genetics

Expression Quantitative Trait Loci Acting Across Multiple Tissues Are Enriched in Inherited Risk for Coronary Artery DiseaseCLINICAL PERSPECTIVE

(2015) Hassan Foroughi Asl et al.   Circulation-Cardiovascular Genetics

Mechanisms of Atherothrombosis and Vascular Response to Primary Percutaneous Coronary Intervention in Women Versus Men With Acute Myocardial Infarction

(2014) Giulio Guagliumi et al.   JACC-Cardiovascular Interventions

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

(2014) Yoko Kojima et al.   JOURNAL OF CLINICAL INVESTIGATION

Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A

(2014) Khelifa Arab et al.   MOLECULAR CELL

GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes

(2014) John D. Eicher et al.   NUCLEIC ACIDS RESEARCH

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation

(2014) Clint L. Miller et al.   PLoS Genetics

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

(2014) Ville-Petteri Mäkinen et al.   PLoS Genetics

ADAMTS7 Cleavage and Vascular Smooth Muscle Cell Migration Is Affected by a Coronary-Artery-Disease-Associated Variant

(2013) Xiangyuan Pu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

Identification of CAD candidate genes in GWAS loci and their expression in vascular cells

(2013) Ayca Erbilgin et al.   JOURNAL OF LIPID RESEARCH

In Vivo Diagnosis of Plaque Erosion and Calcified Nodule in Patients With Acute Coronary Syndrome by Intravascular Optical Coherence Tomography

(2013) Haibo Jia et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Extensive Variation in Chromatin States Across Humans

(2013) M. Kasowski et al.   SCIENCE

Identification of Genetic Variants That Affect Histone Modifications in Human Cells

(2013) G. McVicker et al.   SCIENCE

Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus

(2013) Clint L. Miller et al.   PLoS Genetics

Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks

(2013) Lesca M. Holdt et al.   PLoS Genetics

Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis

(2012) Matthias Derwall et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation

(2012) Nicholas J. Leeper et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

c-Ski inhibits the proliferation of vascular smooth muscle cells via suppressing Smad3 signaling but stimulating p38 pathway

(2012) Jun Li et al.   CELLULAR SIGNALLING

The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors

(2012) A. Acharya et al.   DEVELOPMENT

Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart

(2012) Caitlin M. Braitsch et al.   DEVELOPMENTAL BIOLOGY

Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells

(2012) A. Motterle et al.   HUMAN MOLECULAR GENETICS

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(2012) Lasse Folkersen et al.   MOLECULAR MEDICINE

DNase I sensitivity QTLs are a major determinant of human expression variation

(2012) Jacob F. Degner et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

A Tale of Coronary Artery Disease and Myocardial Infarction

(2012) Elizabeth G. Nabel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clan Genomics and the Complex Architecture of Human Disease

(2011) James R. Lupski et al.   CELL

Leiomodin 1, a New Serum Response Factor-dependent Target Gene Expressed Preferentially in Differentiated Smooth Muscle Cells

(2011) Vivek Nanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans

(2011) Maxime Rotival et al.   PLoS Genetics

Systems Genetics Analysis of Gene-by-Environment Interactions in Human Cells

(2010) Casey E. Romanoski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21

(2010) Lesca M. Holdt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Association of Genetic Risk Variants With Expression of Proximal Genes Identifies Novel Susceptibility Genes for Cardiovascular Disease

(2010) Lasse Folkersen et al.   Circulation-Cardiovascular Genetics

Liver and Adipose Expression Associated SNPs Are Enriched for Association to Type 2 Diabetes

(2010) Hua Zhong et al.   PLoS Genetics

Functional Analysis of the Chromosome 9p21.3 Coronary Artery Disease Risk Locus

(2009) Olga Jarinova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries

(2009) Li Wang et al.   CIRCULATION RESEARCH

Growing Epidemic of Coronary Heart Disease in Low- and Middle-Income Countries

(2009) Thomas A. Gaziano et al.   CURRENT PROBLEMS IN CARDIOLOGY

Mapping complex disease traits with global gene expression

(2009) William Cookson et al.   NATURE REVIEWS GENETICS

PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

(2008) James A. Thomas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

High-Resolution Mapping and Characterization of Open Chromatin across the Genome

(2008) Alan P. Boyle et al.   CELL

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

(2008) Anna Helgadottir et al.   NATURE GENETICS

Revealing the architecture of gene regulation: the promise of eQTL studies

(2008) Yoav Gilad et al.   TRENDS IN GENETICS