Challenges of applying multicellular tumor spheroids in preclinical phase
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Title
Challenges of applying multicellular tumor spheroids in preclinical phase
Authors
Keywords
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Journal
Cancer Cell International
Volume 21, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-03-05
DOI
10.1186/s12935-021-01853-8
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Note: Only part of the references are listed.- Efficacy and safety of anticancer drug combinations: a meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compounds
- (2020) Denis L. Jardim et al. OncoImmunology
- Mechanism of droplet-formation in a supersonic microfluidic spray device
- (2020) T. Kartanas et al. APPLIED PHYSICS LETTERS
- Collective forces of tumor spheroids in three-dimensional biopolymer networks
- (2020) Christoph Mark et al. eLife
- MCF7 Spheroid Development: New Insight about Spatio/Temporal Arrangements of TNTs, Amyloid Fibrils, Cell Connections, and Cellular Bridges
- (2020) Laura Pulze et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Modeling neoplastic disease with spheroids and organoids
- (2020) Michele Zanoni et al. Journal of Hematology & Oncology
- Mathematical modelling reveals cellular dynamics within tumour spheroids
- (2020) Joshua A. Bull et al. PLoS Computational Biology
- Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine
- (2020) Zarema Gilazieva et al. Cancers
- Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment
- (2019) Tristan Courau et al. Journal for ImmunoTherapy of Cancer
- Preparation and characterization of size-controlled glioma spheroids using agarose hydrogel microwells
- (2019) Fereshtehsadat Mirab et al. PLoS One
- The comet assay applied to HepG2 liver spheroids
- (2019) Elisabeth Elje et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Laser-based 3D bioprinting for spatial and size control of tumor spheroids and embryoid bodies
- (2019) David M. Kingsley et al. Acta Biomaterialia
- Quantitative Size-Based Analysis of Tumor Spheroids and Responses to Therapeutics
- (2019) Pradip Shahi Thakuri et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells
- (2019) Rone Aparecido De Grandis et al. BIOORGANIC CHEMISTRY
- A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells
- (2019) Julia Klicks et al. BMC CANCER
- Three-dimensional cell culture can be regulated by vibration: low-frequency vibration increases the size of olfactory ensheathing cell spheroids
- (2019) Lachlan J. Beckingham et al. Journal of Biological Engineering
- In vitro lung cancer multicellular tumor spheroid formation using a microfluidic device
- (2019) Sang Woo Lee et al. BIOTECHNOLOGY AND BIOENGINEERING
- Micropocket hydrogel devices for all-in-one formation, assembly, and analysis of aggregate-based tissues
- (2019) Lisa Zhao et al. Biofabrication
- Enhanced morphological and functional differences of pancreatic cancer with epithelial or mesenchymal characteristics in 3D culture
- (2019) Yuuki Shichi et al. Scientific Reports
- Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration
- (2018) Maria Kalli et al. ANNALS OF BIOMEDICAL ENGINEERING
- Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research
- (2018) Bu-Wei Huang et al. JOURNAL OF CONTROLLED RELEASE
- Mass fabrication of uniform sized 3D tumor spheroid using high-throughput microfluidic system
- (2018) Bongseop Kwak et al. JOURNAL OF CONTROLLED RELEASE
- Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma
- (2018) Yeonhwa Song et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Emerging tumor spheroids technologies for 3D in vitro cancer modeling
- (2018) Tânia Rodrigues et al. PHARMACOLOGY & THERAPEUTICS
- Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
- (2018) Khashayar Moshksayan et al. SENSORS AND ACTUATORS B-CHEMICAL
- Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles
- (2018) Hongxu Lu et al. Small
- An improved method for culturing patient-derived colorectal cancer spheroids
- (2018) Hiroyuki Miyoshi et al. Oncotarget
- Facile Tumor Spheroids Formation in Large Quantity with Controllable Size and High Uniformity
- (2018) Wentao Shi et al. Scientific Reports
- Exclusion from spheroid formation identifies loss of essential cell-cell adhesion molecules in colon cancer cells
- (2018) Mira Stadler et al. Scientific Reports
- Searching Synergistic Dose Combinations for Anticancer Drugs
- (2018) Zuojing Yin et al. Frontiers in Pharmacology
- Scalable Multiplexed Drug-Combination Screening Platforms Using 3D Microtumor Model for Precision Medicine
- (2018) Zhixiong Zhang et al. Small
- Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient
- (2018) Theresa Mulholland et al. Scientific Reports
- 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
- (2018) Ana S. Nunes et al. BIOTECHNOLOGY AND BIOENGINEERING
- A Microfluidic Spheroid Culture Device with a Concentration Gradient Generator for High-Throughput Screening of Drug Efficacy
- (2018) Wanyoung Lim et al. MOLECULES
- Generation of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening
- (2018) Jong Min Lee et al. Scientific Reports
- Bioengineering-inspired three-dimensional culture systems: Organoids to create tumor microenvironment
- (2018) Pelin Saglam-Metiner et al. GENE
- Application of microfluidic chip technology in pharmaceutical analysis: A review
- (2018) Ping Cui et al. Journal of Pharmaceutical Analysis
- Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening
- (2017) Marie Millard et al. International Journal of Nanomedicine
- Cell-like pressure sensors reveal increase of mechanical stress towards the core of multicellular spheroids under compression
- (2017) M. E. Dolega et al. Nature Communications
- Development and cytotoxic response of two proliferative MDA-MB-231 and non-proliferative SUM1315 three-dimensional cell culture models of triple-negative basal-like breast cancer cell lines
- (2017) Dubois Clémence et al. Oncotarget
- Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening
- (2017) Robson L. F. Amaral et al. Frontiers in Physiology
- Comparative Study of Multicellular Tumor Spheroid Formation Methods and Implications for Drug Screening
- (2017) Maria F. Gencoglu et al. ACS Biomaterials-Science & Engineering
- The Scalable Standardized Biofabrication of Tissue Spheroids from Different Cell Types Using Nonadhesive Technology
- (2017) Elizaveta V. Koudan et al. 3D Printing and Additive Manufacturing
- Comparative Study of Multicellular Tumor Spheroid Formation Methods and Implications for Drug Screening
- (2017) Maria F. Gencoglu et al. ACS Biomaterials Science & Engineering
- High-Content Monitoring of Drug Effects in a 3D Spheroid Model
- (2017) Frédérique Mittler et al. Frontiers in Oncology
- Spheroid arrays for high-throughput single-cell analysis of spatial patterns and biomarker expression in 3D
- (2017) Delyan P. Ivanov et al. Scientific Reports
- Role of KCNB1 in the prognosis of gliomas and autophagy modulation
- (2017) Hao-Yuan Wang et al. Scientific Reports
- Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip
- (2016) Yu Shrike Zhang et al. BIOMATERIALS
- 3D tumor spheroids: an overview on the tools and techniques used for their analysis
- (2016) Elisabete C. Costa et al. BIOTECHNOLOGY ADVANCES
- Recapitulating epithelial tumor microenvironment in vitro using three dimensional tri-culture of human epithelial, endothelial, and mesenchymal cells
- (2016) Surya P. Lamichhane et al. BMC CANCER
- Biphasic modeling of brain tumor biomechanics and response to radiation treatment
- (2016) Stelios Angeli et al. JOURNAL OF BIOMECHANICS
- Generation of Multicellular Breast Cancer Tumor Spheroids: Comparison of Different Protocols
- (2016) Karolin Froehlich et al. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- Mini-pillar array for hydrogel-supported 3D culture and high-content histologic analysis of human tumor spheroids
- (2016) Jihoon Kang et al. LAB ON A CHIP
- Scaling and automation of a high-throughput single-cell-derived tumor sphere assay chip
- (2016) Yu-Heng Cheng et al. LAB ON A CHIP
- Developing multi-cellular tumor spheroid model (MCTS) in the chitosan/collagen/alginate (CCA) fibrous scaffold for anticancer drug screening
- (2016) Jian-Zheng Wang et al. Materials Science & Engineering C-Materials for Biological Applications
- Spheroid-based 3-dimensional culture models: Gene expression and functionality in head and neck cancer
- (2016) MARIANNE SCHMIDT et al. ONCOLOGY REPORTS
- Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment
- (2016) Silvio Däster et al. Oncotarget
- Comparative analysis of tumor spheroid generation techniques for differential in vitro drug toxicity
- (2016) Shreya Raghavan et al. Oncotarget
- Reproducible Construction of Surface Tension-Mediated Honeycomb Concave Microwell Arrays for Engineering of 3D Microtissues with Minimal Cell Loss
- (2016) GeonHui Lee et al. PLoS One
- 3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained
- (2016) Michele Zanoni et al. Scientific Reports
- 3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis
- (2015) Jin-Young Kim et al. JOURNAL OF BIOTECHNOLOGY
- Associations of chemo- and radio-resistant phenotypes with the gap junction, adhesion and extracellular matrix in a three-dimensional culture model of soft sarcoma
- (2015) Chujie Bai et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- A cell-based sensor of fluid shear stress for microfluidics
- (2015) Sarvesh Varma et al. LAB ON A CHIP
- High-throughput, deterministic single cell trapping and long-term clonal cell culture in microfluidic devices
- (2015) Huaying Chen et al. LAB ON A CHIP
- Controllable organization and high throughput production of recoverable 3D tumors using pneumatic microfluidics
- (2015) Wenming Liu et al. LAB ON A CHIP
- Media additives to promote spheroid circularity and compactness in hanging drop platform
- (2015) Brendan M. Leung et al. Biomaterials Science
- Spherical Cancer Models in Tumor Biology
- (2015) Louis-Bastien Weiswald et al. NEOPLASIA
- Generation of Multicellular Tumor Spheroids with Microwell-Based Agarose Scaffolds for Drug Testing
- (2015) Xue Gong et al. PLoS One
- 3D cell culture systems modeling tumor growth determinants in cancer target discovery
- (2014) Claudio R. Thoma et al. ADVANCED DRUG DELIVERY REVIEWS
- Cell therapy, 3D culture systems and tissue engineering for cardiac regeneration
- (2014) Maximilian Y. Emmert et al. ADVANCED DRUG DELIVERY REVIEWS
- Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells
- (2014) Dami An et al. Biomolecules & Therapeutics
- Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo
- (2014) John A. Hickman et al. Biotechnology Journal
- The extracellular matrix modulates the hallmarks of cancer
- (2014) M. W. Pickup et al. EMBO REPORTS
- 3D tumor models: history, advances and future perspectives
- (2014) Parul Benien et al. Future Oncology
- 3D Cell Culture Systems: Advantages and Applications
- (2014) Maddaly Ravi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- A microfluidic-based platform for tumour spheroid culture, monitoring and drug screening
- (2014) K. Kwapiszewska et al. LAB ON A CHIP
- A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids
- (2014) Janine Ruppen et al. LAB ON A CHIP
- Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations
- (2013) Kristie M. Charoen et al. BIOMATERIALS
- Development of an in Vitro 3D Tumor Model to Study Therapeutic Efficiency of an Anticancer Drug
- (2013) Crystal S. Shin et al. MOLECULAR PHARMACEUTICS
- AlgiMatrix™ Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies
- (2013) Chandraiah Godugu et al. PLoS One
- A practical guide for the fabrication of microfluidic devices using glass and silicon
- (2012) Ciprian Iliescu et al. Biomicrofluidics
- Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation
- (2012) Maria Vinci et al. BMC BIOLOGY
- Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy
- (2012) A. McIntyre et al. CLINICAL CANCER RESEARCH
- Implication of Tumor Microenvironment in Chemoresistance: Tumor-Associated Stromal Cells Protect Tumor Cells from Cell Death
- (2012) Magali Castells et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Development of Multicellular Tumor Spheroid (MCTS) Culture from Breast Cancer Cell and a High Throughput Screening Method Using the MTT Assay
- (2012) Wan Yong Ho et al. PLoS One
- Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line
- (2012) Stephen J. Fey et al. TOXICOLOGICAL SCIENCES
- Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor
- (2011) Yinghuan Li et al. ADVANCED DRUG DELIVERY REVIEWS
- Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth
- (2011) Michael S. Samuel et al. CANCER CELL
- A software-programmable microfluidic device for automated biology
- (2011) Luis M. Fidalgo et al. LAB ON A CHIP
- Mechanical compression drives cancer cells toward invasive phenotype
- (2011) J. M. Tse et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
- (2010) Yi-Chung Tung et al. ANALYST
- Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells
- (2010) Daniela Loessner et al. BIOMATERIALS
- Preparation of arrays of cell spheroids and spheroid-monolayer cocultures within a microfluidic device
- (2010) Tomoaki Okuyama et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage
- (2010) Victoria Tovar et al. JOURNAL OF HEPATOLOGY
- Integrins and Extracellular Matrix in Mechanotransduction
- (2010) M. A. Schwartz Cold Spring Harbor Perspectives in Biology
- Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells
- (2009) Lisa A. Gurski et al. BIOMATERIALS
- A self-contained microfluidic cell culture system
- (2009) Baoyue Zhang et al. BIOMEDICAL MICRODEVICES
- Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells
- (2009) Gang Cheng et al. PLoS One
- 3-D Tumor Model forIn VitroEvaluation of Anticancer Drugs
- (2008) Jayme L. Horning et al. MOLECULAR PHARMACEUTICS
- Biodegradable PCL scaffolds with an interconnected spherical pore network for tissue engineering
- (2007) R. Izquierdo et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
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