Searching Synergistic Dose Combinations for Anticancer Drugs

Application of Combination High-Throughput Phenotypic Screening and Target Identification Methods for the Discovery of Natural Product-Based Combination Drugs

(2017) Monica Isgut et al.   MEDICINAL RESEARCH REVIEWS

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

(2017) Kyuho Han et al.   NATURE BIOTECHNOLOGY

Cancer: Identifying synergistic drug combinations

(2017) Crunkhorn Sarah   NATURE REVIEWS DRUG DISCOVERY

A Fully Automated High-Throughput Zebrafish Behavioral Ototoxicity Assay

(2017) Douglas W. Todd et al.   Zebrafish

Single and Combination Drug Screening with Aqueous Biphasic Tumor Spheroids

(2017) Pradip Shahi Thakuri et al.   SLAS Discovery

Spheroid arrays for high-throughput single-cell analysis of spatial patterns and biomarker expression in 3D

(2017) Delyan P. Ivanov et al.   Scientific Reports

Optimization of drug combinations using Feedback System Control

(2016) Patrycja Nowak-Sliwinska et al.   Nature Protocols

Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model

(2016) Aleidy Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism-Independent Optimization of Combinatorial Nanodiamond and Unmodified Drug Delivery Using a Phenotypically Driven Platform Technology

(2015) Hann Wang et al.   ACS Nano

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

(2015) Andrea Weiss et al.   ANGIOGENESIS

Systematic discovery of drug interaction mechanisms

(2015) G. Chevereau et al.   Molecular Systems Biology

Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer

(2015) Yi Sun et al.   Nature Communications

Preclinical optimization of a broad-spectrum anti-bladder cancer tri-drug regimen via the Feedback System Control (FSC) platform

(2015) Qi Liu et al.   Scientific Reports

Multi-Scale Agent-Based Multiple Myeloma Cancer Modeling and the Related Study of the Balance between Osteoclasts and Osteoblasts

(2015) Minna Qiao et al.   PLoS One

A streamlined search technology for identification of synergistic drug combinations

(2015) Andrea Weiss et al.   Scientific Reports

Synergistic Inhibitory Effect of Berberine and d-Limonene on Human Gastric Carcinoma Cell Line MGC803

(2014) Xiu-Zhen Zhang et al.   JOURNAL OF MEDICINAL FOOD

A community computational challenge to predict the activity of pairs of compounds

(2014) Mukesh Bansal et al.   NATURE BIOTECHNOLOGY

A Diverse Stochastic Search Algorithm for Combination Therapeutics

(2014) Mehmet Umut Caglar et al.   Biomed Research International

Novel Resveratrol and 5-Fluorouracil Coencapsulated in PEGylated Nanoliposomes Improve Chemotherapeutic Efficacy of Combination against Head and Neck Squamous Cell Carcinoma

(2014) Aarti Mohan et al.   Biomed Research International

Synergistic effects of pemetrexed and amrubicin in non-small cell lung cancer cell lines: Potential for combination therapy

(2013) Yukihisa Hatakeyama et al.   CANCER LETTERS

Multi-scale agent-based modeling on melanoma and its related angiogenesis analysis

(2013) Jun Wang et al.   Theoretical Biology and Medical Modelling

Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts

(2011) Eric Deharo et al.   MALARIA JOURNAL

Synergistic Effects of Foretinib with HER-Targeted Agents in MET and HER1- or HER2-Coactivated Tumor Cells

(2011) L. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Systematic exploration of synergistic drug pairs

(2011) M. Cokol et al.   Molecular Systems Biology

An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells

(2011) Hideaki Tsutsui et al.   Nature Communications

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

The application of drug dose equivalence in the quantitative analysis of receptor occupation and drug combinations

(2010) Ronald J. Tallarida et al.   PHARMACOLOGY & THERAPEUTICS

Statistical Metamodeling for Revealing Synergistic Antimicrobial Interactions

(2010) Chia Hsiang Chen et al.   PLoS One

Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm

(2008) Pak Kin Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Search Algorithms as a Framework for the Optimization of Drug Combinations

(2008) Diego Calzolari et al.   PLoS Computational Biology