Integrative computational approach identifies drug targets in CD4+ T-cell-mediated immune disorders
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Title
Integrative computational approach identifies drug targets in CD4+ T-cell-mediated immune disorders
Authors
Keywords
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Journal
npj Systems Biology and Applications
Volume 7, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-01-22
DOI
10.1038/s41540-020-00165-3
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Note: Only part of the references are listed.- Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap
- (2019) Jüri Reimand et al. Nature Protocols
- Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells
- (2019) Rodolfo Soria-Castro et al. Journal of Immunology Research
- Targeting metabolism to regulate immune responses in autoimmunity and cancer
- (2019) Chirag H. Patel et al. NATURE REVIEWS DRUG DISCOVERY
- Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease
- (2019) William C. Reisdorf et al. PLoS One
- PKM2-dependent metabolic reprogramming in CD4+ T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis
- (2018) Silin Lü et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Recon3D enables a three-dimensional view of gene variation in human metabolism
- (2018) Elizabeth Brunk et al. NATURE BIOTECHNOLOGY
- Adenosine deaminase deficiency: a review
- (2018) Aisling M. Flinn et al. Orphanet Journal of Rare Diseases
- The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation
- (2018) Jonathan Muri et al. Nature Communications
- GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4 + T Cells and Is Immunosuppressive in Type 1 Diabetes
- (2018) Amol K. Bhandage et al. EBioMedicine
- Immunotropic Effects and Proposed Mechanism of Action for 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors (Statins)
- (2018) T. I. Arefieva et al. BIOCHEMISTRY-MOSCOW
- Escher-FBA: a web application for interactive flux balance analysis
- (2018) Elliot Rowe et al. BMC Systems Biology
- Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation
- (2018) Gaojian Lian et al. eLife
- A Mechanistic Computational Model Reveals That Plasticity of CD4+ T Cell Differentiation Is a Function of Cytokine Composition and Dosage
- (2018) Bhanwar Lal Puniya et al. Frontiers in Physiology
- Drug repurposing: progress, challenges and recommendations
- (2018) Sudeep Pushpakom et al. NATURE REVIEWS DRUG DISCOVERY
- Database resources of the National Center for Biotechnology Information
- (2018) Eric W Sayers et al. NUCLEIC ACIDS RESEARCH
- The Gene Ontology Resource: 20 years and still GOing strong
- (2018) NUCLEIC ACIDS RESEARCH
- miR-425 regulates inflammatory cytokine production in CD4 + T cells via N-Ras upregulation in primary biliary cholangitis
- (2017) Ryo Nakagawa et al. JOURNAL OF HEPATOLOGY
- Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation
- (2017) Ian A. Bettencourt et al. JOURNAL OF IMMUNOLOGY
- Fatty acid synthase regulates the pathogenicity of Th17 cells
- (2017) Kathryne E. Young et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The Drug Repurposing Hub: a next-generation drug library and information resource
- (2017) Steven M Corsello et al. NATURE MEDICINE
- The Reactome Pathway Knowledgebase
- (2017) Antonio Fabregat et al. NUCLEIC ACIDS RESEARCH
- DrugBank 5.0: a major update to the DrugBank database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- Amino-acid transporters in T-cell activation and differentiation
- (2017) Wenkai Ren et al. Cell Death & Disease
- STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth
- (2017) Sarah MacPherson et al. Cell Reports
- Cholesterol Metabolism in T Cells
- (2017) Andreas Bietz et al. Frontiers in Immunology
- Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes
- (2017) Hector M. Granados et al. PLoS One
- Restricting Glutamine or Glutamine-Dependent Purine and Pyrimidine Syntheses Promotes Human T Cells with High FOXP3 Expression and Regulatory Properties
- (2016) Barbara Metzler et al. JOURNAL OF IMMUNOLOGY
- Recon 2.2: from reconstruction to model of human metabolism
- (2016) Neil Swainston et al. Metabolomics
- Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+T lymphocytes
- (2016) Nerea Osinalde et al. MOLECULAR & CELLULAR PROTEOMICS
- Genome-wide metabolic model to improve understanding of CD4+ T cell metabolism, immunometabolism and application in drug design
- (2016) Feifei Han et al. Molecular BioSystems
- OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines
- (2016) Wei-Hua Chen et al. NUCLEIC ACIDS RESEARCH
- The ChEMBL database in 2017
- (2016) Anna Gaulton et al. NUCLEIC ACIDS RESEARCH
- UniProt: the universal protein knowledgebase
- (2016) NUCLEIC ACIDS RESEARCH
- The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible
- (2016) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- Metabolic pathways in T cell activation and lineage differentiation
- (2016) Luís Almeida et al. SEMINARS IN IMMUNOLOGY
- Integration of Metabolic Modeling with Gene Co-expression Reveals Transcriptionally Programmed Reactions Explaining Robustness in Mycobacterium tuberculosis
- (2016) Bhanwar Lal Puniya et al. Scientific Reports
- Pyruvate Kinase M2: A Potential Target for Regulating Inflammation
- (2016) Jose C. Alves-Filho et al. Frontiers in Immunology
- T cell metabolism drives immunity
- (2015) Michael D. Buck et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Glucose Oxidation Is Critical for CD4+T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus
- (2015) Yiming Yin et al. JOURNAL OF IMMUNOLOGY
- T cell metabolic reprogramming and plasticity
- (2015) Maria Slack et al. MOLECULAR IMMUNOLOGY
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- KEGG as a reference resource for gene and protein annotation
- (2015) Minoru Kanehisa et al. NUCLEIC ACIDS RESEARCH
- A validated gene regulatory network and GWAS identifies early regulators of T cell–associated diseases
- (2015) Mika Gustafsson et al. Science Translational Medicine
- Normalization of CD4 + T cell metabolism reverses lupus
- (2015) Yiming Yin et al. Science Translational Medicine
- CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid arthritis: evidence from a case–control study
- (2015) Hua Ye et al. ARTHRITIS RESEARCH & THERAPY
- Escher: A Web Application for Building, Sharing, and Embedding Data-Rich Visualizations of Biological Pathways
- (2015) Zachary A. King et al. PLoS Computational Biology
- T Helper Lymphocyte Subsets and Plasticity in Autoimmunity and Cancer: An Overview
- (2015) Ekaterina A. Ivanova et al. Biomed Research International
- A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
- (2015) Longfei Mao et al. Computational and Structural Biotechnology Journal
- The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function
- (2014) Andrew N. Macintyre et al. Cell Metabolism
- Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
- (2014) Valerie A. Gerriets et al. JOURNAL OF CLINICAL INVESTIGATION
- Transduction with the Antioxidant Enzyme Catalase Protects Human T Cells against Oxidative Stress
- (2014) T. Ando et al. JOURNAL OF IMMUNOLOGY
- Nicotinamide Phosphoribosyl Transferase/Pre-B Cell Colony-Enhancing Factor/Visfatin Is Required for Lymphocyte Development and Cellular Resistance to Genotoxic Stress
- (2014) A. Rongvaux et al. JOURNAL OF IMMUNOLOGY
- BioModels: ten-year anniversary
- (2014) Vijayalakshmi Chelliah et al. NUCLEIC ACIDS RESEARCH
- Perturbed Glucose Metabolism: Insights into Multiple Sclerosis Pathogenesis
- (2014) Deepali Mathur et al. Frontiers in Neurology
- MicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS)
- (2013) Margareta Jernås et al. BMC IMMUNOLOGY
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
- (2013) Chih-Hao Chang et al. CELL
- Profiling of human CD4+ T-cell subsets identifies the TH2-specific noncoding RNA GATA3-AS1
- (2013) Huan Zhang et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells
- (2013) Zhen Yang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Integrated gene co-expression network analysis in the growth phase of Mycobacterium tuberculosis reveals new potential drug targets
- (2013) Bhanwar Lal Puniya et al. Molecular BioSystems
- Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
- (2013) Markus Kleinewietfeld et al. NATURE
- A community-driven global reconstruction of human metabolism
- (2013) Ines Thiele et al. NATURE BIOTECHNOLOGY
- Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies Peroxisome Proliferator-Activated Receptor Gamma as an intrinsic negative regulator of viral replication
- (2013) Annie Bernier et al. Retrovirology
- Systems Modeling of Molecular Mechanisms Controlling Cytokine-driven CD4+ T Cell Differentiation and Phenotype Plasticity
- (2013) Adria Carbo et al. PLoS Computational Biology
- Predicting Drug Targets and Biomarkers of Cancer via Genome-Scale Metabolic Modeling
- (2012) L. Jerby et al. CLINICAL CANCER RESEARCH
- Adenosine Deaminase in the Modulation of Immune System and its Potential as a Novel Target for Treatment of Inflammatory Disorders
- (2012) Luca Antonioli et al. CURRENT DRUG TARGETS
- Rarity of Human T Helper 17 Cells Is due to Retinoic Acid Orphan Receptor-Dependent Mechanisms that Limit Their Expansion
- (2012) Veronica Santarlasci et al. IMMUNITY
- Metabolic reprogramming and metabolic dependency in T cells
- (2012) Ruoning Wang et al. IMMUNOLOGICAL REVIEWS
- Requirements for Growth and IL-10 Expression of Highly Purified Human T Regulatory Cells
- (2012) Benedetta Bonacci et al. JOURNAL OF CLINICAL IMMUNOLOGY
- NCBI GEO: archive for functional genomics data sets—update
- (2012) Tanya Barrett et al. NUCLEIC ACIDS RESEARCH
- Increased Membrane Cholesterol in Lymphocytes Diverts T-Cells toward an Inflammatory Response
- (2012) Jacqueline Surls et al. PLoS One
- Different Subtypes of GABA-A Receptors Are Expressed in Human, Mouse and Rat T Lymphocytes
- (2012) Suresh K. Mendu et al. PLoS One
- GABA is an effective immunomodulatory molecule
- (2011) Zhe Jin et al. AMINO ACIDS
- Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis
- (2011) Jide Tian et al. AUTOIMMUNITY
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- Analysis of the Transcriptional Program of Developing Induced Regulatory T Cells
- (2011) Iryna Prots et al. PLoS One
- Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge
- (2010) Adam J. Case et al. FREE RADICAL BIOLOGY AND MEDICINE
- Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions
- (2010) Aarash Bordbar et al. Molecular Systems Biology
- GeneCards Version 3: the human gene integrator
- (2010) M. Safran et al. Database-The Journal of Biological Databases and Curation
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
- (2009) Da Wei Huang et al. Nature Protocols
- Catastrophic NAD+ Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE
- (2009) Santina Bruzzone et al. PLoS One
- Distinct roles of helper T-cell subsets in a systemic autoimmune disease
- (2008) K. K. Hoyer et al. BLOOD
- CD4 T cells: fates, functions, and faults
- (2008) J. Zhu et al. BLOOD
- T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis
- (2008) Chris J. Hedegaard et al. IMMUNOLOGY
- Context-Specific Metabolic Networks Are Consistent with Experiments
- (2008) Scott A. Becker et al. PLoS Computational Biology
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