Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

Valproic acid promotes a decrease in mycobacterial survival by enhancing nitric oxide production in macrophages stimulated with IFN-γ

(2019) Erik Nieto-Patlán et al.   TUBERCULOSIS

An Integrated View of Immunometabolism

(2018) Yun Sok Lee et al.   CELL

Evaluation of the efficacy of valproic acid and suberoylanilide hydroxamic acid (vorinostat) in enhancing the effects of first-line tuberculosis drugs against intracellular Mycobacterium tuberculosis

(2018) Martin Rao et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacetylase Inhibitor

(2017) Alessandro Venosa et al.   TOXICOLOGICAL SCIENCES

Epigenetics and Trained Immunity

(2017) Charlotte D.C.C. van der Heijden et al.   ANTIOXIDANTS & REDOX SIGNALING

DNA Methylation Changes in Valproic Acid-Treated HeLa Cells as Assessed by Image Analysis, Immunofluorescence and Vibrational Microspectroscopy

(2017) Giovana M. B. Veronezi et al.   PLoS One

The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3

(2017) Lulu Ni et al.   Scientific Reports

Butyrate enhances antibacterial effects while suppressing other features of alternative activation in IL-4-induced macrophages

(2016) Maria R. Fernando et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Loperamide Restricts Intracellular Growth ofMycobacterium tuberculosisin Lung Macrophages

(2016) Esmeralda Juárez et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Incidence of Neutropenia With Valproate and Quetiapine Combination Treatment in Subjects With Acquired Brain Injuries

(2016) Hee Jung Park et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Valproic Acid and Lithium Meditate Anti-Inflammatory Effects by Differentially Modulating Dendritic Cell Differentiation and Function

(2016) Sy-Jye Leu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Immunometabolic circuits in trained immunity

(2016) Rob J.W. Arts et al.   SEMINARS IN IMMUNOLOGY

Modulation of Donor-Specific Antibody Production After Organ Transplantation by Valproic Acid

(2016) Junsheng Ye et al.   TRANSPLANTATION

Valproic acid ameliorates coxsackievirus-B3-induced viral myocarditis by modulating Th17/Treg imbalance

(2016) Haibin Jin et al.   Virology Journal

Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis

(2016) Katarina Lyberg et al.   Oncotarget

Expression of non-secreted IL-4 is associated with HDAC inhibitor-induced cell death, histone acetylation and c-Jun regulation in human gamma/delta T-cells

(2016) Jaydeep Bhat et al.   Oncotarget

Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells

(2016) Jie Gao et al.   Protein & Cell

Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat

(2015) Sabbir Khan et al.   BIOCHIMIE

Modulation of human gamma/delta T-cell activation and phenotype by histone deacetylase inhibitors

(2015) Jaydeep Bhat et al.   CELLULAR IMMUNOLOGY

Valproate modulates glucose metabolism in patients with epilepsy after first exposure

(2015) Aleksei Rakitin et al.   EPILEPSIA

Valproic Acid Ameliorates Graft-versus-Host Disease by Downregulating Th1 and Th17 Cells

(2015) Jun Long et al.   JOURNAL OF IMMUNOLOGY

Effects of cytarabine on activation of human T cells – cytarabine has concentration-dependent effects that are modulated both by valproic acid and all-trans retinoic acid

(2015) Elisabeth Ersvaer et al.   BMC Pharmacology & Toxicology

Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response

(2015) Hong Zan et al.   Frontiers in Immunology

Genome-Wide Analysis Reveals Selective Modulation of microRNAs and mRNAs by Histone Deacetylase Inhibitor in B Cells Induced to Undergo Class-Switch DNA Recombination and Plasma Cell Differentiation

(2015) Tian Shen et al.   Frontiers in Immunology

Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway

(2014) Pengfei Shi et al.   BMC CANCER

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

(2014) M. Schiebler et al.   EMBO Molecular Medicine

Dendritic cell development requires histone deacetylase activity

(2014) Heike Chauvistré et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Modulation of Treg function improves adenovirus vector-mediated gene expression in the airway

(2014) Y Nagai et al.   GENE THERAPY

Histone deacetylase inhibitor valproic acid affects plasmacytoid dendritic cells phenotype and function

(2014) Jessy Arbez et al.   IMMUNOBIOLOGY

A novel mechanism for inhibition of lipopolysaccharide-induced proinflammatory cytokine production by valproic acid

(2014) Ulziisaikhan Jambalganiin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses

(2014) Clayton A. White et al.   JOURNAL OF IMMUNOLOGY

Valproic Acid Prevents Penile Fibrosis and Erectile Dysfunction in Cavernous Nerve‐Injured Rats

(2014) Johanna L. Hannan et al.   Journal of Sexual Medicine

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Lipopolysaccharide prevents valproic acid-induced apoptosis via activation of nuclear factor-κB and inhibition of p53 activation

(2013) Bilegtsaikhan Tsolmongyn et al.   CELLULAR IMMUNOLOGY

Histone deacetylase inhibition by Japanese encephalitis virus in monocyte/macrophages: A novel viral immune evasion strategy

(2013) Dwaipayan Adhya et al.   IMMUNOBIOLOGY

Inhibition of human B-cell development into plasmablasts by histone deacetylase inhibitor valproic acid

(2013) Anne-Kathrin Kienzler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Response of Secondary Genes to Lipopolysaccharides in Macrophages Depends on Histone Deacetylase and Phosphorylation of C/EBP 

(2013) N. Serrat et al.   JOURNAL OF IMMUNOLOGY

HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity

(2013) Hae Jin Kee et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Valproic acid pathway

(2013) Yogita Ghodke-Puranik et al.   Pharmacogenetics and Genomics

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Levetiracetam but not valproate inhibits function of CD8+ T lymphocytes

(2013) Gang Li et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Influence of Histone Deacetylase Inhibitors and DNA-Methyltransferase Inhibitors on the NK Cell-Mediated Lysis of Pediatric B-Lineage Leukemia

(2013) Matthias Manuel Pfeiffer et al.   Frontiers in Oncology

Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma

(2012) Song Gu et al.   ANTI-CANCER DRUGS

Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors

(2012) T Montero-Melendez et al.   CELL DEATH AND DIFFERENTIATION

DNA demethylation and histone H3K9 acetylation determine the active transcription of the NKG2D gene in human CD8+T and NK cells

(2012) Alba Fernández-Sánchez et al.   Epigenetics

Impact of HDAC inhibitors on dendritic cell functions

(2012) Jihane Frikeche et al.   EXPERIMENTAL HEMATOLOGY

Valproic acid inhibits proliferation of EB virus-infected natural killer cells

(2012) Kazuyasu Fujii et al.   Hematology

Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells

(2012) Han Xian Aw Yeang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Antiepileptic Drug Valproic Acid Restores T Cell Homeostasis and Ameliorates Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2012) Jie Lv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valproic Acid Treatment Is Associated With Altered Leukocyte Subset Development

(2012) Marije Bartels et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Valproic acid attenuates blood-spinal cord barrier disruption by inhibiting matrix metalloprotease-9 activity and improves functional recovery after spinal cord injury

(2012) Jee Y. Lee et al.   JOURNAL OF NEUROCHEMISTRY

The Histone Deacetylase Inhibitor Valproic Acid Lessens NK Cell Action against Oncolytic Virus-Infected Glioblastoma Cells by Inhibition of STAT5/T-BET Signaling and Generation of Gamma Interferon

(2012) Christopher A. Alvarez-Breckenridge et al.   JOURNAL OF VIROLOGY

Valproic Acid-Induced Eosinophilic Pleural Effusion

(2012) Zvi Kamenetsky et al.   NEUROLOGIST

Valproic acid ameliorates inflammation in experimental autoimmune encephalomyelitis rats

(2012) Z. Zhang et al.   NEUROSCIENCE

Effects of valproate on Tax and HBZ expression in HTLV-1 and HAM/TSP T lymphocytes

(2011) G. Belrose et al.   BLOOD

Histone Deacetylase Inhibition by Sodium Valproate Regulates Polarization of Macrophage Subsets

(2011) Chenming Wu et al.   DNA AND CELL BIOLOGY

Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease

(2011) Simon G. Royce et al.   Epigenetics

Impact of valproic acid on dendritic cells function

(2011) Jihane Frikeche et al.   IMMUNOBIOLOGY

HDACi: molecular mechanisms and therapeutic implications in the innate immune system

(2011) Bandar Ali Suliman et al.   IMMUNOLOGY AND CELL BIOLOGY

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

(2011) Omar Khan et al.   IMMUNOLOGY AND CELL BIOLOGY

Upregulation of NKG2D ligands and enhanced natural killer cell cytotoxicity by hydralazine and valproate

(2011) A. Due�as-Gonz�lez   INTERNATIONAL JOURNAL OF ONCOLOGY

Histone Deacetylase Inhibitors Impair Antibacterial Defenses of Macrophages

(2011) Matteo Mombelli et al.   JOURNAL OF INFECTIOUS DISEASES

Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression

(2011) Lucas E. Rossi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Valproic Acid Attenuates Proteinuria and Kidney Injury

(2011) K. Van Beneden et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion

(2011) Kyuseok Kim et al.   RESUSCITATION

Une pleurésie à éosinophiles liée à la prise d’acide valproïque

(2011) C. Bally et al.   Revue de Pneumologie Clinique

Valproic Acid Increases Susceptibility to Endotoxin Shock Through Enhanced Release of High-Mobility Group Box 1

(2011) Shinsuke Sugiura et al.   SHOCK

Valproic acid perturbs hematopoietic homeostasis by inhibition of erythroid differentiation and activation of the myelo-monocytic pathway

(2010) Sébastien Chateauvieux et al.   BIOCHEMICAL PHARMACOLOGY

Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection

(2010) T. Roger et al.   BLOOD

Secretion of MIP-1β and MIP-1α by CD8+ T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage

(2010) Kevin O. Saunders et al.   CELLULAR IMMUNOLOGY

Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs

(2010) Tatiana Akimova et al.   CLINICAL IMMUNOLOGY

Bryostatin-1 Synergizes with Histone Deacetylase Inhibitors to Reactivate HIV-1 from Latency

(2010) Moises Perez et al.   CURRENT HIV RESEARCH

Valproate induces DNA demethylation in nuclear extracts from adult mouse brain

(2010) Erbo Dong et al.   Epigenetics

The Histone Deacetylase Inhibitor ITF2357 Decreases Surface CXCR4 and CCR5 Expression on CD4+ T-Cells and Monocytes and is Superior to Valproic Acid for Latent HIV-1 Expression in Vitro

(2010) Shay Matalon et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Valproate Treatment of Human Cord Blood CD4-positive Effector T Cells Confers on Them the Molecular Profile (MicroRNA Signature and FOXP3 Expression) of Natural Regulatory CD4-positive Cells through Inhibition of Histone Deacetylase

(2010) Hussein Fayyad-Kazan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular and Therapeutic Potential and Toxicity of Valproic Acid

(2010) Sébastien Chateauvieux et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Valproate Increases Glutaminase and Decreases Glutamine Synthetase Activities in Primary Cultures of Rat Brain Astrocytes

(2010) Roger M. Collins et al.   JOURNAL OF NEUROCHEMISTRY

How GABA generates depolarization

(2010) Nicholas C. Spitzer   JOURNAL OF PHYSIOLOGY-LONDON

Neutrophilic differentiation modulates the apoptotic response of HL-60 cells to sodium butyrate and sodium valproate

(2010) J. Vrba et al.   NEOPLASMA

Antiretroviral Intensification and Valproic Acid Lack Sustained Effect on Residual HIV-1 Viremia or Resting CD4+ Cell Infection

(2010) Nancie M. Archin et al.   PLoS One

Epigenetic regulation of CD8+ T-lymphocyte mediated suppression of HIV-1 replication

(2010) Kevin O. Saunders et al.   VIROLOGY

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

(2010) Julia M. Wagner et al.   Clinical Epigenetics

Biochemical, Molecular and Epigenetic Mechanisms of Valproic Acid Neuroprotection

(2010) Barbara Monti et al.   Current Molecular Pharmacology

Divalproex Sodium-Induced Eosinophilic Pleural Effusion

(2009) Prachi Joshi et al.   AMERICAN JOURNAL OF THERAPEUTICS

Clinical and Biological Effects of Valproic Acid as a Histone Deacetylase Inhibitor on Tumor and Surrogate Tissues: Phase I/II Trial of Valproic acid and Epirubicin/FEC

(2009) P. Munster et al.   CLINICAL CANCER RESEARCH

Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis

(2009) Sandra J. Saouaf et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas -deficient MRL/lpr−/− murine model of autoimmune lymphoproliferative syndrome (ALPS)

(2009) Kennichi C. Dowdell et al.   EXPERIMENTAL HEMATOLOGY

Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cellsin vitroandin vivo

(2009) Inge Mannaerts et al.   HEPATOLOGY

Is There a Future for Histone Deacetylase Inhibitors in the Pharmacotherapy of Psychiatric Disorders?

(2009) D. R. Grayson et al.   MOLECULAR PHARMACOLOGY

Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells

(2008) Nancy M Archin et al.   AIDS

Delayed-Onset Neutropenia with Divalproex Sodium

(2008) Steven C Stoner et al.   ANNALS OF PHARMACOTHERAPY

Valproic acid as epigenetic cancer drug: Preclinical, clinical and transcriptional effects on solid tumors

(2008) Alfonso Duenas-Gonzalez et al.   CANCER TREATMENT REVIEWS

Valproic acid attenuates inflammation in experimental autoimmune neuritis

(2008) Z. Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effect of Aging on Glucuronidation of Valproic Acid in Human Liver Microsomes and the Role of UDP-Glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10

(2008) U. A. Argikar et al.   DRUG METABOLISM AND DISPOSITION

Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: A review

(2008) M. F. B. Silva et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY