Pyruvate Kinase M2: A Potential Target for Regulating Inflammation

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions

(2016) Abhishek Bhardwaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in gastric cancer

(2016) Ran Tang et al.   Oncotarget

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer

(2015) Peng Yang et al.   CELLULAR SIGNALLING

Eukaryotic initiation factor 6 modulates myofibroblast differentiation at transforming growth factor- 1 transcription level via H2A.Z occupancy and Sp1 recruitment

(2015) S.-s. Yang et al.   JOURNAL OF CELL SCIENCE

Lack of Evidence for PKM2 Protein Kinase Activity

(2015) Aaron M. Hosios et al.   MOLECULAR CELL

Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells

(2015) PARUNYA CHAIYAWAT et al.   ONCOLOGY REPORTS

Glutamine enema regulates colonic ubiquitinated proteins but not proteasome activities during TNBS-induced colitis leading to increased mitochondrial activity

(2015) Julien Bertrand et al.   PROTEOMICS

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

miR-122 inhibits cancer cell malignancy by targeting PKM2 in gallbladder carcinoma

(2015) Wei Lu et al.   TUMOR BIOLOGY

PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation

(2015) Valeria Iansante et al.   Nature Communications

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis

(2015) Cheng Zhan et al.   PLoS One

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

(2015) Weibo Luo et al.   Oncotarget

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

(2015) Katharina Bluemlein et al.   Oncotarget

Pyruvate Kinase M2 Regulates Apoptosis of Intestinal Epithelial Cells in Crohn’s Disease

(2014) Qiyun Tang et al.   DIGESTIVE DISEASES AND SCIENCES

Pyruvate kinase M2 and cancer: an updated assessment

(2014) Mohd Askandar Iqbal et al.   FEBS LETTERS

Serine and glycine metabolism in cancer

(2014) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Control of glioma cell death and differentiation by PKM2–Oct4 interaction

(2014) M Morfouace et al.   Cell Death & Disease

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

(2014) Liangchun Yang et al.   Nature Communications

Activation of Akt protects cancer cells from growth inhibition induced by PKM2 knockdown

(2014) Xiaodong Qin et al.   Cell and Bioscience

The Warburg effect then and now: From cancer to inflammatory diseases

(2013) Eva M. Palsson-McDermott et al.   BIOESSAYS

Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma

(2013) S. R. P. McDonnell et al.   BLOOD

Nuclear PKM2 regulates the Warburg effect

(2013) Weiwei Yang et al.   CELL CYCLE

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

(2013) Lei Lv et al.   MOLECULAR CELL

PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells

(2013) Yuhui Jiang et al.   MOLECULAR CELL

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

(2013) H. P. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

(2012) Charles Kung et al.   CHEMISTRY & BIOLOGY

Fecal M2-PK in Children with Crohn’s Disease: A Preliminary Report

(2012) A. S. Day et al.   DIGESTIVE DISEASES AND SCIENCES

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

(2012) Michael S. Goldberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions

(2012) K. E. Keller et al.   SCIENCE

Emerging roles of PKM2 in cell metabolism and cancer progression

(2012) Weibo Luo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase

(2011) I Mor et al.   ONCOGENE

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons

(2011) Zhenxun Wang et al.   Journal of Molecular Cell Biology

Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells

(2010) B. Kefas et al.   NEURO-ONCOLOGY

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

(2010) C. V. Clower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY

The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2

(2009) Gilles A. Spoden et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling

(2008) Thian-Sze Wong et al.   INTERNATIONAL JOURNAL OF CANCER

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

(2007) Jungwoon Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY