Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+T lymphocytes

Acetylation of NDPK-D Regulates Its Subcellular Localization and Cell Survival

(2015) Yuki Fujita et al.   PLoS One

Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia

(2015) Jung Seok Hwang et al.   Scientific Reports

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

The IL-2 cytokine family in cancer immunotherapy

(2014) Geok Choo Sim et al.   CYTOKINE & GROWTH FACTOR REVIEWS

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

PPARγ ligand production is tightly linked to clonal expansion during initiation of adipocyte differentiation

(2014) Philip Hallenborg et al.   JOURNAL OF LIPID RESEARCH

Off-Line High-pH Reversed-Phase Fractionation for In-Depth Phosphoproteomics

(2014) Tanveer S. Batth et al.   JOURNAL OF PROTEOME RESEARCH

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

Phosphorylation Site Dynamics of Early T-cell Receptor Signaling

(2014) Lily A. Chylek et al.   PLoS One

Simultaneous dissection and comparison of IL-2 and IL-15 signaling pathways by global quantitative phosphoproteomics

(2014) Nerea Osinalde et al.   PROTEOMICS

Chromatin and signaling

(2013) Tamaki Suganuma et al.   CURRENT OPINION IN CELL BIOLOGY

Epigenetic regulation of inducible gene expression in the immune system

(2013) Pek Siew Lim et al.   IMMUNOLOGY

Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells

(2013) Toshiro Migita et al.   INTERNATIONAL JOURNAL OF CANCER

Qualitatively Different T Cell Phenotypic Responses to IL-2 versus IL-15 Are Unified by Identical Dependences on Receptor Signal Strength and Duration

(2013) A. Arneja et al.   JOURNAL OF IMMUNOLOGY

The Nuclear Protein ALY Binds to and Modulates the Activity of Transcription Factor E2F2

(2013) Nerea Osinalde et al.   MOLECULAR & CELLULAR PROTEOMICS

Chimeric γc cytokine receptors confer cytokine independent engraftment of human T lymphocytes

(2013) Michelle R. Hunter et al.   MOLECULAR IMMUNOLOGY

E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes

(2013) Usua Laresgoiti et al.   NUCLEIC ACIDS RESEARCH

Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae

(2013) L. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Rac1 Protein Regulates Glycogen Phosphorylase Activation and Controls Interleukin (IL)-2-dependent T Cell Proliferation

(2012) Onetsine Arrizabalaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

(2012) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors

(2011) Sid P. Kerkar et al.   JOURNAL OF CLINICAL INVESTIGATION

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics

(2011) Nerea Osinalde et al.   Journal of Proteomics

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

When Signaling Kinases Meet Histones and Histone Modifiers in the Nucleus

(2011) Sung Hee Baek   MOLECULAR CELL

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes

(2011) Maria N Navarro et al.   NATURE IMMUNOLOGY

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model

(2009) A. Di Stasi et al.   BLOOD

T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera

(2009) Takahiro Sogo et al.   CYTOKINE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Dissection of the insulin signaling pathway via quantitative phosphoproteomics

(2008) M. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology