Mitochondrial Ion Channels of the Inner Membrane and Their Regulation in Cell Death Signaling

Reply to Bernardi: The mitochondrial permeability transition pore and the ATP synthase

(2020) John E. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Swine acute diarrhea syndrome coronavirus-induced apoptosis is caspase- and cyclophilin D- dependent

(2020) Jiyu Zhang et al.   Emerging Microbes & Infections

Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca 2+ ‐dependent death of cancer cells

(2020) Francesco Ciscato et al.   EMBO REPORTS

A 20/20 view of ANT function in mitochondrial biology and necrotic cell death

(2020) Michael J. Bround et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of the mitochondrial permeability transition improves bone fracture repair

(2020) Brianna H. Shares et al.   BONE

Cyclosporine: an old weapon in the fight against Coronaviruses

(2020) Adam Molyvdas et al.   EUROPEAN RESPIRATORY JOURNAL

Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection

(2020) Michela Carraro et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NCLX prevents cell death during adrenergic activation of the brown adipose tissue

(2020) Essam A. Assali et al.   Nature Communications

Cyclophilin D: An Integrator of Mitochondrial Function

(2020) Georgios Amanakis et al.   Frontiers in Physiology

The Antiviral Properties of Cyclosporine. Focus on Coronavirus, Hepatitis C Virus, Influenza Virus, and Human Immunodeficiency Virus Infections

(2020) Paulina Glowacka et al.   Biology-Basel

Cryo-EM structure of the entire mammalian F-type ATP synthase

(2020) Gergely Pinke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial F-ATP synthase as the permeability transition pore

(2020) Christoph Gerle   PHARMACOLOGICAL RESEARCH

Structure of the dimeric ATP synthase from bovine mitochondria

(2020) Tobias E. Spikes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family

(2020) Roberta Peruzzo et al.   Redox Biology

High mitochondrial Ca2+ content increases cancer cell proliferation upon inhibition of mitochondrial permeability transition pore (mPTP)

(2019) Saverio Marchi et al.   CELL CYCLE

Mitochondrial Megachannel Resides in Monomeric ATP Synthase

(2019) Nelli Mnatsakanyan et al.   BIOPHYSICAL JOURNAL

Progress in understanding mitochondrial calcium uniporter complex‐mediated calcium signalling: A potential target for cancer treatment

(2019) Chaochu Cui et al.   BRITISH JOURNAL OF PHARMACOLOGY

Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration

(2019) Jędrzej M. Małecki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase

(2019) Joe Carroll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo real-time dynamics of ATP and ROS production in axonal mitochondria show decoupling in mouse models of peripheral neuropathies

(2019) Gerben van Hameren et al.   Acta Neuropathologica Communications

Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells

(2019) Roberta Peruzzo et al.   Cancers

APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore

(2019) Shrijal S. Shah et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Identification of an ATP-sensitive potassium channel in mitochondria

(2019) Angela Paggio et al.   NATURE

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

(2019) Jason Karch et al.   Science Advances

Single-Channel Properties of the ROMK-Pore-Forming Subunit of the Mitochondrial ATP-Sensitive Potassium Channel

(2019) Michał Laskowski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutant huntingtin fails to directly impair brain mitochondria

(2019) James Hamilton et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development and Application of Sub-Mitochondrial Targeted Ca2 + Biosensors

(2019) Markus Waldeck-Weiermair et al.   Frontiers in Cellular Neuroscience

Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore

(2019) Andrea Urbani et al.   Nature Communications

Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death

(2019) Elena Britti et al.   CELL CALCIUM

Lipid-Mediated Modulation of Intracellular Ion Channels and Redox State: Physiopathological Implications

(2018) Marisa Brini et al.   ANTIOXIDANTS & REDOX SIGNALING

Calcium and regulation of the mitochondrial permeability transition

(2018) Valentina Giorgio et al.   CELL CALCIUM

Mitochondrial Ca 2+ -activated K + channels and their role in cell life and death pathways

(2018) Inge E. Krabbendam et al.   CELL CALCIUM

Glycogen synthase kinase-3β opens mitochondrial permeability transition pore through mitochondrial hexokinase II dissociation

(2018) Takamitsu Tanaka et al.   Journal of Physiological Sciences

Melatonin Balance the Autophagy and Apoptosis by Regulating UCP2 in the LPS-Induced Cardiomyopathy

(2018) Pan Pan et al.   MOLECULES

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Porcine deltacoronavirus induces caspase-dependent apoptosis through activation of the cytochrome c -mediated intrinsic mitochondrial pathway

(2018) Yoo Jin Lee et al.   VIRUS RESEARCH

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming

(2018) Zhongfu Ying et al.   Cell Metabolism

Efficient proximity labeling in living cells and organisms with TurboID

(2018) Tess C Branon et al.   NATURE BIOTECHNOLOGY

MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+

(2018) Kimberli J. Kamer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Influence of MicroRNAs on Mitochondrial Calcium

(2018) Carolina Jaquenod De Giusti et al.   Frontiers in Physiology

Pharmacological modulation of mitochondrial ion channels

(2018) Luigi Leanza et al.   BRITISH JOURNAL OF PHARMACOLOGY

New Advances in Adaptive Thermogenesis: UCP1 and Beyond

(2018) Edward T. Chouchani et al.   Cell Metabolism

Mitochondrial Ca 2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity

(2017) Zhiwei Dong et al.   MOLECULAR CELL

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

Oxidative metabolism and Ca 2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease

(2017) James Hamilton et al.   NEUROCHEMISTRY INTERNATIONAL

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

(2017) Amit Agarwal et al.   NEURON

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting calcium signaling in cancer therapy

(2017) Chaochu Cui et al.   Acta Pharmaceutica Sinica B

Endoplasmic Reticulum–Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target

(2017) Galdo Bustos et al.   Frontiers in Oncology

Enjoy the Trip: Calcium in Mitochondria Back and Forth

(2016) Diego De Stefani et al.   Annual Review of Biochemistry

On the structural possibility of pore-forming mitochondrial F o F 1 ATP synthase

(2016) Christoph Gerle   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The mitochondrial permeability transition pore in AD 2016: An update

(2016) Lucia Biasutto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pharmacological targeting of ion channels for cancer therapy: In vivo evidences

(2016) Luigi Leanza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of mitochondrial calcium in plants versus animals

(2016) Stephan Wagner et al.   JOURNAL OF EXPERIMENTAL BOTANY

Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease

(2016) Simon J. Beck et al.   Nature Communications

PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells

(2016) Corina T. Madreiter-Sokolowski et al.   Nature Communications

Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone

(2016) Laura C. Shum et al.   PLoS One

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Ion channels in the regulation of apoptosis

(2015) Artem Kondratskyi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure and function of the mitochondrial calcium uniporter complex

(2015) Diego De Stefani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment

(2015) Cristina Correia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ca2+handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's disease

(2015) Jessica J. Pellman et al.   JOURNAL OF NEUROCHEMISTRY

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Engineering of a light-gated potassium channel

(2015) C. Cosentino et al.   SCIENCE

Overexpression of uncoupling protein-2 in cancer: metabolic and heat changes, inhibition and effects on drug resistance

(2015) Michael A. Pitt   INFLAMMOPHARMACOLOGY

Silencing the KCNK9 potassium channel (TASK-3) gene disturbs mitochondrial function, causes mitochondrial depolarization, and induces apoptosis of human melanoma cells

(2014) Dénes Nagy et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

The H+-ATP synthase: A gate to ROS-mediated cell death or cell survival

(2014) Inmaculada Martínez-Reyes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

At the right distance: ER-mitochondria juxtaposition in cell life and death

(2014) Deborah Naon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Joiner et al. reply

(2014) Mei-ling A. Joiner et al.   NATURE

Mitochondrial Ca2+ uniporter and CaMKII in heart

(2014) Francesca Fieni et al.   NATURE

miRNAs 182 and 183 Are Necessary to Maintain Adult Cone Photoreceptor Outer Segments and Visual Function

(2014) Volker Busskamp et al.   NEURON

Ion channels and apoptosis in cancer

(2014) C. D. Bortner et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mitochondrial Channels: Ion Fluxes and More

(2014) Ildiko Szabo et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction

(2013) Amalia M. Dolga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications

(2013) Saverio Marchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

(2013) Lee J. Martin et al.   NEUROBIOLOGY OF AGING

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular ion channels and cancer

(2013) Luigi Leanza et al.   Frontiers in Physiology

Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25

(2012) Saverio Marchi et al.   CURRENT BIOLOGY

CaMKII determines mitochondrial stress responses in heart

(2012) Mei-ling A. Joiner et al.   NATURE

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidative stress, mitochondrial permeability transition pore opening and cell death during hypoxia–reoxygenation in adult cardiomyocytes

(2011) Rana Assaly et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma

(2011) Nataliya Razumilava et al.   HEPATOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Absence of mitochondrial uncoupling protein 1 affects apoptosis in thymocytes, thymocyte/T-cell profile and peripheral T-cell number

(2010) Alison E. Adams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis

(2010) I Szabò et al.   CELL DEATH AND DIFFERENTIATION

Calcium-dependent mitochondrial function and dysfunction in neurons

(2010) Natalia B. Pivovarova et al.   FEBS Journal

Signal transduction to the permeability transition pore

(2010) Andrea Rasola et al.   FEBS LETTERS

Identification of the miR-106b 25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

(2010) L. Poliseno et al.   Science Signaling

Cyclophilin D in mitochondrial pathophysiology

(2009) Valentina Giorgio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

(2009) Elena Palma et al.   HUMAN MOLECULAR GENETICS

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

Mitochondria and calcium in health and disease

(2008) M DUCHEN et al.   CELL CALCIUM

p38 mitogen-activated protein kinase regulates canonical Wnt- -catenin signaling by inactivation of GSK3 

(2008) R. K. Bikkavilli et al.   JOURNAL OF CELL SCIENCE

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

(2008) Douglas P Millay et al.   NATURE MEDICINE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

(2008) I. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA