PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells

Analysis of the structure and function of EMRE in a yeast expression system

(2016) Takenori Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

By Regulating Mitochondrial Ca2+-Uptake UCP2 Modulates Intracellular Ca2+

(2016) Lukas Jaroslaw Motloch et al.   PLoS One

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

(2016) Dhanendra Tomar et al.   Cell Reports

EMRE Is a Matrix Ca 2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca 2+ Uniporter

(2016) Horia Vais et al.   Cell Reports

Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling

(2016) Nóra M. Márkus et al.   PLoS One

Structure and function of the mitochondrial calcium uniporter complex

(2015) Diego De Stefani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter

(2015) Horia Vais et al.   Cell Metabolism

The Ca2+-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca2+ Uptake

(2015) Carmelina Petrungaro et al.   Cell Metabolism

UCP2 inhibition sensitizes breast cancer cells to therapeutic agents by increasing oxidative stress

(2015) Daniel Gabriel Pons et al.   FREE RADICAL BIOLOGY AND MEDICINE

The mitochondrial Ca2+ uniporter complex

(2015) J. Kevin Foskett et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Arginine methyltransferases as novel therapeutic targets for breast cancer

(2015) A. Morettin et al.   MUTAGENESIS

The molecular era of the mitochondrial calcium uniporter

(2015) Kimberli J. Kamer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

UCP2 modulates single-channel properties of a MCU-dependent Ca2+ inward current in mitochondria

(2015) Alexander I. Bondarenko et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ca2+signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+uniporter geneMCU

(2015) Santhanam Shanmughapriya et al.   Science Signaling

PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145

(2015) Yanzhong Yang et al.   Nature Communications

F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression

(2015) Xin Tian et al.   Oncotarget

Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca2+

(2015) Markus Waldeck-Weiermair et al.   Scientific Reports

Ca2+signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+uniporter geneMCU

(2015) Santhanam Shanmughapriya et al.   Science Signaling

Molecular control of mitochondrial calcium uptake

(2014) Diego De Stefani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The uniporter: From newly identified parts to function

(2014) Kimberli J. Kamer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The elusive importance of being a mitochondrial Ca2+ uniporter

(2014) Diana Pendin et al.   CELL CALCIUM

Molecular mechanism of mitochondrial calcium uptake

(2014) Lele Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake

(2014) L. Wang et al.   EMBO JOURNAL

SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress–mediated cell death

(2014) Nicholas E. Hoffman et al.   MOLECULAR BIOLOGY OF THE CELL

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation

(2014) Jun-Ichi Sakamaki et al.   NATURE CELL BIOLOGY

Non-histone protein methylation as a regulator of cellular signalling and function

(2014) Kyle K. Biggar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity

(2014) Alexandra Kukat et al.   PLoS Genetics

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

Molecularly Distinct Routes of Mitochondrial Ca2+Uptake Are Activated Depending on the Activity of the Sarco/Endoplasmic Reticulum Ca2+ATPase (SERCA)

(2013) Markus Waldeck-Weiermair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

Selective Inhibition by Ethanol of Mitochondrial Calcium Influx Mediated by Uncoupling Protein-2 in Relation to N-Methyl-D-Aspartate Cytotoxicity in Cultured Neurons

(2013) Ryo Fukumori et al.   PLoS One

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

(2013) Nicholas E. Hoffman et al.   Cell Reports

Tissue-specific and age-dependent expression of protein arginine methyltransferases (PRMTs) in male rat tissues

(2012) Eunyoung Hong et al.   BIOGERONTOLOGY

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS

(2012) Dorothee Dormann et al.   EMBO JOURNAL

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Possible involvement of mitochondrial uncoupling protein-2 in cytotoxicity mediated by acquired N-methyl-d-aspartate receptor channels

(2012) Ryo Fukumori et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondria, calcium-dependent neuronal death and neurodegenerative disease

(2012) Michael R. Duchen   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

PMeS: Prediction of Methylation Sites Based on Enhanced Feature Encoding Scheme

(2012) Shao-Ping Shi et al.   PLoS One

Activity of the mitochondrial calcium uniporter varies greatly between tissues

(2012) Francesca Fieni et al.   Nature Communications

New Aspects of Mitochondrial Uncoupling Proteins (UCPs) and Their Roles in Tumorigenesis

(2011) Delira Robbins et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Uncoupling Protein 3 (UCP3) Modulates the Activity of Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) by Decreasing Mitochondrial ATP Production

(2011) Umberto De Marchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deacetylation and methylation at histone H3 lysine 9 (H3K9) coordinate chromosome condensation during cell cycle progression

(2011) Jin-Ah Park et al.   MOLECULES AND CELLS

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins

(2011) Konstantinos Tripsianes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Uncoupling protein 3 adjusts mitochondrial Ca2+ uptake to high and low Ca2+ signals

(2010) Markus Waldeck-Weiermair et al.   CELL CALCIUM

The contribution of UCP2 and UCP3 to mitochondrial Ca2+ uptake is differentially determined by the source of supplied Ca2+

(2010) Markus Waldeck-Weiermair et al.   CELL CALCIUM

Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production

(2010) Kevin Bonham et al.   FEBS Journal

Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers

(2010) Masanori Yoshimatsu et al.   INTERNATIONAL JOURNAL OF CANCER

Ca2+ Hot Spots on the Mitochondrial Surface Are Generated by Ca2+ Mobilization from Stores, but Not by Activation of Store-Operated Ca2+ Channels

(2010) Marta Giacomello et al.   MOLECULAR CELL

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells

(2009) Elinor J. Griffiths et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter

(2009) D. Jiang et al.   SCIENCE

UCPs — unlikely calcium porters

(2008) Paul S. Brookes et al.   NATURE CELL BIOLOGY