Mutant huntingtin fails to directly impair brain mitochondria

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice

(2019) Aris A. Polyzos et al.   Cell Metabolism

The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders

(2018) Anuradha Tarafdar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative metabolism and Ca 2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease

(2017) James Hamilton et al.   NEUROCHEMISTRY INTERNATIONAL

Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases

(2017) Pauline Gaignard et al.   Frontiers in Aging Neuroscience

Oxidative metabolism in YAC128 mouse model of Huntington's disease

(2015) James Hamilton et al.   HUMAN MOLECULAR GENETICS

Ca2+handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's disease

(2015) Jessica J. Pellman et al.   JOURNAL OF NEUROCHEMISTRY

Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling

(2015) Nickolay Brustovetsky   MOLECULAR NEUROBIOLOGY

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Inhibition of mitochondrial protein import by mutant huntingtin

(2014) Hiroko Yano et al.   NATURE NEUROSCIENCE

Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in vivo

(2013) Eugenia Trushina et al.   HUMAN MOLECULAR GENETICS

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

(2013) Maria Damiano et al.   HUMAN MOLECULAR GENETICS

Forebrain Striatal-Specific Expression of Mutant Huntingtin Protein in Vivo Induces Cell-Autonomous Age-Dependent Alterations in Sensitivity to Excitotoxicity and Mitochondrial Function

(2011) Soong Ho Kim et al.   ASN Neuro

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

In Vitroandin VivoAggregation of a Fragment of Huntingtin Protein Directly Causes Free Radical Production

(2011) Sarah Hands et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease

(2011) Ming-Chang Chiang et al.   NEUROBIOLOGY OF DISEASE

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Impaired Regulation of Brain Mitochondria by Extramitochondrial Ca2+in Transgenic Huntington Disease Rats

(2008) Frank N. Gellerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

(2008) A. L. Orr et al.   JOURNAL OF NEUROSCIENCE

ΔΨm-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

(2003) Tatyana V. Votyakova et al.   JOURNAL OF NEUROCHEMISTRY