APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity

(2019) Justin Chun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1 Risk Variants Cause Podocytes Injury through Enhancing Endoplasmic Reticulum Stress

(2018) Hongxiu Wen et al.   BIOSCIENCE REPORTS

The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition pore

(2018) Christopher P. Baines et al.   CELL CALCIUM

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

ApoL1 Overexpression Drives Variant-Independent Cytotoxicity

(2017) John F. O'Toole et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion

(2017) Daniel Granado et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease

(2017) Salim S Hayek et al.   NATURE MEDICINE

APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

(2017) Anneli Cooper et al.   eLife

APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction

(2016) Lijun Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death

(2016) Yulong Fu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1–Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes

(2016) Etty Kruzel-Davila et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques

(2016) Massimo Bonora et al.   Nature Protocols

Apolipoprotein L1 and Kidney Disease in African Americans

(2016) David J. Friedman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1

(2015) Atanu K. Khatua et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Protein domains of APOL1 and its risk variants

(2015) Xiqian Lan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Vascular smooth muscle cells contribute to APOL1-induced podocyte injury in HIV milieu

(2015) Xiqian Lan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells

(2015) Dongmei Cheng et al.   JOURNAL OF LIPID RESEARCH

APOL1 toxin, innate immunity, and kidney injury

(2015) Sophie Limou et al.   KIDNEY INTERNATIONAL

MitoFates: Improved Prediction of Mitochondrial Targeting Sequences and Their Cleavage Sites

(2015) Yoshinori Fukasawa et al.   MOLECULAR & CELLULAR PROTEOMICS

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: Relevance to trypanosome lysis

(2015) Russell Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases

(2015) Opeyemi A. Olabisi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1

(2015) Gilles Vanwalleghem et al.   Nature Communications

ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death

(2014) Siqin Zhaorigetu et al.   Autophagy

Localization of APOL1 Protein and mRNA in the Human Kidney: Nondiseased Tissue, Primary Cells, and Immortalized Cell Lines

(2014) L. Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evolution of the primate trypanolytic factor APOL1

(2014) R. Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Trypanosoma brucei gambiense resistance to human serum

(2013) Pierrick Uzureau et al.   NATURE

Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak

(2012) Martin Jastroch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Treatment of Primary FSGS in Adults

(2012) S. M. Korbet   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Null Alleles from a Rural Village in India Do Not Correlate with Glomerulosclerosis

(2012) Duncan B. Johnstone et al.   PLoS One

Genetics of kidney failure and the evolving story of APOL1

(2011) David J. Friedman et al.   JOURNAL OF CLINICAL INVESTIGATION

APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy

(2011) J. B. Kopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Population-Based Risk Assessment of APOL1 on Renal Disease

(2011) D. J. Friedman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Localization in Normal Kidney and Nondiabetic Kidney Disease

(2011) S. M. Madhavan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

(2010) Shay Tzur et al.   HUMAN GENETICS

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions

(2009) E. E. Smith et al.   GENOME RESEARCH

Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore

(2008) Anna W.C. Leung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein L1, a Novel Bcl-2 Homology Domain 3-only Lipid-binding Protein, Induces Autophagic Cell Death

(2008) Guanghua Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY