Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore

(2019) Maria A. Neginskaya et al.   Cell Reports

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

(2019) Joshua J. Woods et al.   ACS Central Science

Progress in understanding mitochondrial calcium uniporter complex‐mediated calcium signalling: A potential target for cancer treatment

(2019) Chaochu Cui et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation

(2019) Olha M. Koval et al.   Science Signaling

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

(2019) Shashank Dadsena et al.   Nature Communications

Overcoming Multidrug Resistance through the GLUT1-Mediated and Enzyme-Triggered Mitochondrial Targeting Conjugate with Redox-Sensitive Paclitaxel Release

(2018) Pengkai Ma et al.   ACS Applied Materials & Interfaces

Novel Channels of the Outer Membrane of Mitochondria: Recent Discoveries Change Our View

(2018) Vanessa Checchetto et al.   BIOESSAYS

Mitochondrial Outer Membrane Channels: Emerging Diversity in Transport Processes

(2018) Thomas Becker et al.   BIOESSAYS

RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+Uptake and Promotes Colorectal Oncogenesis

(2018) Fanxin Zeng et al.   CANCER RESEARCH

Mitochondrial Ca 2+ -activated K + channels and their role in cell life and death pathways

(2018) Inge E. Krabbendam et al.   CELL CALCIUM

VDAC1 as a Player in Mitochondria-Mediated Apoptosis and Tar get for Modulating Apoptosis

(2018) Varda Shoshan-Barmatz et al.   CURRENT MEDICINAL CHEMISTRY

Selective induction of cancer cell death by VDAC1-based peptides and their potential use in cancer therapy

(2018) Anna Shteinfer-Kuzmine et al.   Molecular Oncology

The role of the mitochondrial calcium uniporter (MCU) complex in cancer

(2018) Adina Vultur et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation

(2018) Ioana Ferecatu et al.   PLoS One

Cryo-EM structure of a mitochondrial calcium uniporter

(2018) Jiho Yoo et al.   SCIENCE

Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells

(2018) Rong Zhang et al.   Cell Death & Disease

Hypoxic-induced truncation of voltage-dependent anion channel 1 is mediated by both asparagine endopeptidase and calpain 1 activities

(2018) Hadas Pahima et al.   Oncotarget

Mitochondrial Nicotinic Acetylcholine Receptors Support Liver Cells Viability After Partial Hepatectomy

(2018) Kateryna Uspenska et al.   Frontiers in Pharmacology

Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide

(2018) Srinivas Pittala et al.   NEOPLASIA

VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis

(2018) Andrea Magrì et al.   Frontiers in Chemistry

Targeting Bcl-2 for the treatment of multiple myeloma

(2018) Cyrille Touzeau et al.   LEUKEMIA

Cryo-EM structure of a fungal mitochondrial calcium uniporter

(2018) Nam X. Nguyen et al.   NATURE

Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters

(2018) Rozbeh Baradaran et al.   NATURE

Pharmacological modulation of mitochondrial ion channels

(2018) Luigi Leanza et al.   BRITISH JOURNAL OF PHARMACOLOGY

Akt‐mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth

(2018) Saverio Marchi et al.   EMBO JOURNAL

VDAC2 enables BAX to mediate apoptosis and limit tumor development

(2018) Hui San Chin et al.   Nature Communications

Mitochondrial VDAC1 Silencing Leads to Metabolic Rewiring and the Reprogramming of Tumour Cells into Advanced Differentiated States

(2018) Tasleem Arif et al.   Cancers

Bax, Bak and beyond - mitochondrial performance in apoptosis

(2017) Aida Peña-Blanco et al.   FEBS Journal

Synthetic Methods for the Preparation of a Functional Analogue of Ru360, a Potent Inhibitor of Mitochondrial Calcium Uptake

(2017) Sarah R. Nathan et al.   INORGANIC CHEMISTRY

Identification of new channels by systematic analysis of the mitochondrial outer membrane

(2017) Vivien Krüger et al.   JOURNAL OF CELL BIOLOGY

Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1

(2017) Lucie A. Bergdoll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1

(2017) Toshiaki Hosaka et al.   PROTEIN SCIENCE

Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells

(2017) Daniel Bauer et al.   Cell Death & Disease

Mitochondrial markers predict recurrence, metastasis and tamoxifen-resistance in breast cancer patients: Early detection of treatment failure with companion diagnostics

(2017) Federica Sotgia et al.   Oncotarget

Recombinant Human Voltage Dependent Anion Selective Channel Isoform 3 (hVDAC3) Forms Pores with a Very Small Conductance

(2017) Vanessa Checchetto et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Enjoy the Trip: Calcium in Mitochondria Back and Forth

(2016) Diego De Stefani et al.   Annual Review of Biochemistry

What do we not know about mitochondrial potassium channels?

(2016) Michał Laskowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Physiology of intracellular potassium channels: A unifying role as mediators of counterion fluxes?

(2016) Vanessa Checchetto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The mitochondrial permeability transition pore in AD 2016: An update

(2016) Lucia Biasutto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

(2016) R. Salvador-Gallego et al.   EMBO JOURNAL

Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis

(2016) L. Grosse et al.   EMBO JOURNAL

The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α

(2016) Anna Tosatto et al.   EMBO Molecular Medicine

Impact of intracellular ion channels on cancer development and progression

(2016) Roberta Peruzzo et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Ceramide channels and mitochondrial outer membrane permeability

(2016) Marco Colombini   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Regulation of mitochondrial calcium in plants versus animals

(2016) Stephan Wagner et al.   JOURNAL OF EXPERIMENTAL BOTANY

Silencing A7-nAChR levels increases the sensitivity of gastric cancer cells to ixabepilone treatment

(2016) Chao-Chiang Tu et al.   TUMOR BIOLOGY

MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

(2016) Anil Noronha Antony et al.   Nature Communications

Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma

(2016) Angela Zaccagnino et al.   Oncotarget

Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria

(2016) César Cárdenas et al.   Cell Reports

Identification of potential predictive markers of dexamethasone resistance in childhood acute lymphoblastic leukemia

(2016) Nasrin Dehghan-Nayeri et al.   Journal of Cell Communication and Signaling

VDAC3 As a Potential Marker of Mitochondrial Status Is Involved in Cancer and Pathology

(2016) Simona Reina et al.   Frontiers in Oncology

Identification of KCa3.1 Channel as a Novel Regulator of Oxidative Phosphorylation in a Subset of Pancreatic Carcinoma Cell Lines

(2016) Ilya Kovalenko et al.   PLoS One

In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy

(2016) Yusuke Nasu et al.   Scientific Reports

TPGS2k/PLGA Nanoparticles for Overcoming Multidrug Resistance by Interfering Mitochondria of Human Alveolar Adenocarcinoma Cells

(2015) Dong-Fang Wang et al.   ACS Applied Materials & Interfaces

Mitochondrial Ca2+ uniporter is critical for store-operated Ca2+ entry-dependent breast cancer cell migration

(2015) Shihao Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ceramide channels: destabilization by Bcl-xL and role in apoptosis

(2015) Kai-Ti Chang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The mitochondrial voltage-dependent anion channel 1 in tumor cells

(2015) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Uncoupling protein 2 mediates resistance to gemcitabine-induced apoptosis in hepatocellular carcinoma cell lines

(2015) G. Yu et al.   BIOSCIENCE REPORTS

Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors

(2015) Alex I Chernyavsky et al.   BMC CANCER

Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection

(2015) Lara Testai et al.   CARDIOVASCULAR RESEARCH

UCP2 inhibition sensitizes breast cancer cells to therapeutic agents by increasing oxidative stress

(2015) Daniel Gabriel Pons et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of growth-promoting and tumor-protecting effects of epithelial nicotinic acetylcholine receptors

(2015) Alex I. Chernyavsky et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MAC inhibitors antagonize the pro-apoptotic effects of tBid and disassemble Bax / Bak oligomers

(2015) Pablo M. Peixoto et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mechanistic Aspects of Folded Protein Transport by the Twin Arginine Translocase (Tat)

(2015) Kenneth Cline   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells

(2015) Li Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil

(2015) Wei-Yu Chen et al.   TUMOR BIOLOGY

The α7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to taxanes

(2015) Chao-Chiang Tu et al.   TUMOR BIOLOGY

Nicotine Induces Inhibitor of Differentiation-1 in a Src-dependent Pathway Promoting Metastasis and Chemoresistance in Pancreatic Adenocarcinoma

(2015) Jose G. Trevino et al.   NEOPLASIA

BAX channel activity mediates lysosomal disruption linked to Parkinson disease

(2014) Jordi Bové et al.   Autophagy

The mitochondrial permeability transition pore and its adaptive responses in tumor cells

(2014) Andrea Rasola et al.   CELL CALCIUM

The elusive importance of being a mitochondrial Ca2+ uniporter

(2014) Diana Pendin et al.   CELL CALCIUM

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

(2014) S B Ma et al.   CELL DEATH AND DIFFERENTIATION

Correlation between Potassium Channel Expression and Sensitivity to Drug-induced Cell Death in Tumor Cell Lines

(2014) Luigi Leanza et al.   CURRENT PHARMACEUTICAL DESIGN

VDAC phosphorylation, a lipid sensor influencing the cell fate

(2014) Cécile Martel et al.   MITOCHONDRION

Organelle-specific initiation of cell death

(2014) Lorenzo Galluzzi et al.   NATURE CELL BIOLOGY

Mitochondrial ion channels as oncological targets

(2014) L Leanza et al.   ONCOGENE

Mitochondrial Channels: Ion Fluxes and More

(2014) Ildiko Szabo et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial Calcium Uniporter Activity Is Dispensable for MDA-MB-231 Breast Carcinoma Cell Survival

(2014) Duane D. Hall et al.   PLoS One

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

(2014) Dana Westphal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting BCL2 for the Treatment of Lymphoid Malignancies

(2014) Mary Ann Anderson et al.   SEMINARS IN HEMATOLOGY

Mitochondria: from cell death executioners to regulators of cell differentiation

(2014) Atsuko Kasahara et al.   TRENDS IN CELL BIOLOGY

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Death upon a Kiss: Mitochondrial Outer Membrane Composition and Organelle Communication Govern Sensitivity to BAK/BAX-Dependent Apoptosis

(2013) Thibaud T. Renault et al.   CHEMISTRY & BIOLOGY

Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction

(2013) Amalia M. Dolga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia

(2013) L Leanza et al.   LEUKEMIA

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

(2013) Clare V Logan et al.   NATURE GENETICS

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Structural model for the protein-translocating element of the twin-arginine transport system

(2013) F. Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs

(2013) Simona Dinicola et al.   TOXICOLOGY IN VITRO

VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia

(2013) T Prezma et al.   Cell Death & Disease

Role of mitochondrial uncoupling protein 2 in cancer cell resistance to gemcitabine

(2012) Elisa Dalla Pozza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Expression of a Truncated Active Form of VDAC1 in Lung Cancer Associates with Hypoxic Cell Survival and Correlates with Progression to Chemotherapy Resistance

(2012) M. C. Brahimi-Horn et al.   CANCER RESEARCH

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25

(2012) Saverio Marchi et al.   CURRENT BIOLOGY

Induction of Apoptosis in Macrophages via Kv1.3 and Kv1.5 Potassium Channels

(2012) L. Leanza et al.   CURRENT MEDICINAL CHEMISTRY

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells

(2012) Luigi Leanza et al.   EMBO Molecular Medicine

Intracellular BKCa(iBKCa) channels

(2012) Harpreet Singh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Intracellular localization of nicotinic acetylcholine receptors in human cell lines

(2012) O.M. Kalashnyk et al.   LIFE SCIENCES

Role of Ion Channels and Transporters in Cell Migration

(2012) Albrecht Schwab et al.   PHYSIOLOGICAL REVIEWS

Mitochondria Express α7 Nicotinic Acetylcholine Receptors to Regulate Ca2+ Accumulation and Cytochrome c Release: Study on Isolated Mitochondria

(2012) Galyna Gergalova et al.   PLoS One

Mitochondria as Therapeutic Targets for the Treatment of Malignant Disease

(2011) Simone Fulda et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria-Targeted Small Molecule Therapeutics and Probes

(2011) Robin A.J. Smith et al.   ANTIOXIDANTS & REDOX SIGNALING

VDAC isoforms in mammals

(2011) Angela Messina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondrial recoupling: a novel therapeutic strategy for cancer?

(2011) G Baffy et al.   BRITISH JOURNAL OF CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

14-3-3theta Protects against Neurotoxicity in a Cellular Parkinson's Disease Model through Inhibition of the Apoptotic Factor Bax

(2011) Sunny R. Slone et al.   PLoS One

Nicotinic Acetylcholine Receptor Signaling in Tumor Growth and Metastasis

(2011) Sandeep Singh et al.   Journal of Oncology

Multidrug resistance phenotypes and MRS2 mitochondrial magnesium channel: Two players from one stemness?

(2010) Federica I. Wolf et al.   CANCER BIOLOGY & THERAPY

Human mitochondrial Mrs2 protein promotes multidrug resistance in gastric cancer cells by regulating p27, cyclin D1 expression and cytochrome C release

(2010) Yu Chen et al.   CANCER BIOLOGY & THERAPY

Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis

(2010) I Szabò et al.   CELL DEATH AND DIFFERENTIATION

Targeting mitochondria for cancer therapy

(2010) David M. Hockenbery   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Voltage-dependent Inwardly Rectifying Potassium Conductance in the Outer Membrane of Neuronal Mitochondria

(2010) Francesca Fieni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis

(2010) N. Keinan et al.   MOLECULAR AND CELLULAR BIOLOGY

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion

(2009) Franziska B. Mullauer et al.   APOPTOSIS

An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1

(2009) Nicola Sassi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Intermediate conductance Ca2+-activated potassium channel (KCa3.1) in the inner mitochondrial membrane of human colon cancer cells

(2009) Umberto De Marchi et al.   CELL CALCIUM

Voltage-Dependent Potassium Channels Kv1.3 and Kv1.5 in Human Cancer

(2009) J. Bielanska et al.   CURRENT CANCER DRUG TARGETS

Voltage-dependent Anion Channel 1-based Peptides Interact with Bcl-2 to Prevent Antiapoptotic Activity

(2009) Nir Arbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Warburg effect and mitochondrial stability in cancer cells

(2009) Vladimir Gogvadze et al.   MOLECULAR ASPECTS OF MEDICINE

Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation

(2009) Blanca Schafer et al.   MOLECULAR BIOLOGY OF THE CELL

Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax

(2009) H Yamagata et al.   ONCOGENE

The Mitochondrial Uncoupling Protein-2 Promotes Chemoresistance in Cancer Cells

(2008) Z. Derdak et al.   CANCER RESEARCH

Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

(2008) I. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA