Bypassing the Blood–Brain Barrier: Direct Intracranial Drug Delivery in Epilepsies

When Drugs Do Not Work: Alternatives to Antiseizure Medications

(2020) Sara Dawit et al.   Current Neurology and Neuroscience Reports

Networks in Temporal Lobe Epilepsy

(2020) Karina A. González Otárula et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Neuromodulation of Epilepsy Networks

(2020) Nathaniel D. Sisterson et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options

(2020) Wolfgang Löscher et al.   PHARMACOLOGICAL REVIEWS

Early seizure detection for closed loop direct neurostimulation devices in epilepsy

(2019) Matthias Duempelmann   Journal of Neural Engineering

Cortico-striatal synchronization in human focal seizures

(2019) Jerome Aupy et al.   BRAIN

The 100 most-cited articles about convection-enhanced delivery to the brain: a bibliometric analysis

(2019) Victor M. Lu et al.   World Neurosurgery

The Concept of Drug-Resistant Epileptogenic Zone

(2019) Chunbo Zhang et al.   Frontiers in Neurology

Novel therapies for epilepsy in the pipeline

(2019) Boulenouar Mesraoua et al.   EPILEPSY & BEHAVIOR

Pharmacoresistance – Epidemiology, mechanisms, and impact on epilepsy treatment

(2019) Mubeen Janmohamed et al.   NEUROPHARMACOLOGY

Disrupted basal ganglia–thalamocortical loops in focal to bilateral tonic-clonic seizures

(2019) Xiaosong He et al.   BRAIN

Descending projections from thesubstantia nigra pars reticulatadifferentially control seizures

(2019) Evan Wicker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Pharmacogenomics in Antiepileptic Drug Therapy: Current Status and Future Perspectives

(2018) Antonio Gambardella et al.   CURRENT PHARMACEUTICAL DESIGN

Pathophysiology of absence epilepsy: Insights from genetic models

(2018) Antoine Depaulis et al.   NEUROSCIENCE LETTERS

Pharmacogenomics in epilepsy

(2018) Simona Balestrini et al.   NEUROSCIENCE LETTERS

The Subthalamic Nucleus: Unravelling New Roles and Mechanisms in the Control of Action

(2018) Tora Bonnevie et al.   NEUROSCIENTIST

Convection-Enhanced Delivery of Muscimol Into the Bilateral Subthalamic Nuclei of Nonhuman Primates

(2018) John D Heiss et al.   NEUROSURGERY

The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats

(2018) Saeedeh Asadi et al.   BMC NEUROSCIENCE

Advanced fabrication approaches to controlled delivery systems for epilepsy treatment

(2018) Gilles Sebastiaan van Tienderen et al.   Expert Opinion on Drug Delivery

OUP accepted manuscript

(2018)   NEUROSURGERY

Deep brain stimulation for seizure control in drug-resistant epilepsy

(2018) Neil Klinger et al.   Neurosurgical Focus

Practical Management of Epileptic Seizures and Status Epilepticus in Adult Palliative Care Patients

(2018) Wenke Grönheit et al.   Frontiers in Neurology

The epidemiology of drug-resistant epilepsy: A systematic review and meta-analysis

(2018) Linda Kalilani et al.   EPILEPSIA

Localized shape abnormalities in the thalamus and pallidum are associated with secondarily generalized seizures in mesial temporal lobe epilepsy

(2017) Linglin Yang et al.   EPILEPSY & BEHAVIOR

The role of the basal ganglia in the control of seizure

(2017) J. Vuong et al.   JOURNAL OF NEURAL TRANSMISSION

The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP)

(2017) John H. Kehne et al.   NEUROCHEMICAL RESEARCH

Intracerebroventricular Delivery as a Safe, Long-Term Route of Drug Administration

(2017) Jessica L. Cohen-Pfeffer et al.   PEDIATRIC NEUROLOGY

Intra-hippocampal microinjection of oxytocin produced antiepileptic effect on the pentylenetetrazol-induced epilepsy in rats

(2017) Amir Erfanparast et al.   Pharmacological Reports

Development of drug-loaded polymer microcapsules for treatment of epilepsy

(2017) Yu Chen et al.   Biomaterials Science

Large-scale cortico-subcortical functional networks in focal epilepsies: The role of the basal ganglia

(2017) Eva Výtvarová et al.   NeuroImage-Clinical

Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers

(2017) Fei Tang et al.   Frontiers in Neurology

Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier

(2016) David S. Hersh et al.   CURRENT PHARMACEUTICAL DESIGN

Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies

(2016) Wolfgang Löscher   EPILEPSY RESEARCH

SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats

(2016) Elham Kordi Jaz et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Comorbidities of epilepsy: current concepts and future perspectives

(2016) Mark R Keezer et al.   LANCET NEUROLOGY

Evaluation of the Biocompatibility of Polypyrrole Implanted Subdurally in GAERS

(2016) Sebastien H. Bauquier et al.   MACROMOLECULAR BIOSCIENCE

Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models

(2016) Laura Gey et al.   NEUROBIOLOGY OF DISEASE

Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks

(2016) Colin Soper et al.   NEUROBIOLOGY OF DISEASE

Anticonvulsant Effects of Fractions Isolated from Dinoponera quadriceps (Kempt) Ant Venom (Formicidae: Ponerinae)

(2016) Diana Nôga et al.   Toxins

Spatial memory in nonhuman primates implanted with the subdural pharmacotherapy device

(2015) Nandor Ludvig et al.   BEHAVIOURAL BRAIN RESEARCH

Validation of the 6Hz refractory seizure mouse model for intracerebroventricularly administered compounds

(2015) Laura Walrave et al.   EPILEPSY RESEARCH

On-demand pulsatile intracerebral delivery of carisbamate with closed-loop direct neurostimulation therapy in an electrically induced self-sustained focal-onset epilepsy rat model

(2015) Erwin Z. Mangubat et al.   JOURNAL OF NEUROSURGERY

Convection-enhanced delivery to the central nervous system

(2015) Russell R. Lonser et al.   JOURNAL OF NEUROSURGERY

Limbic circuitry of the midline thalamus

(2015) Robert P. Vertes et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Targeting Neuronal Networks with Combined Drug and Stimulation Paradigms Guided by Neuroimaging to Treat Brain Disorders

(2015) Carl L. Faingold et al.   NEUROSCIENTIST

Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats

(2015) Elham Goudarzi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Injectable phenytoin loaded polymeric microspheres for the control of temporal lobe epilepsy in rats

(2015) Jonathan L. Jiang et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Reduction of epileptiform activity through local valproate-implants in a rat neocortical epilepsy model

(2015) Michael P. Rassner et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Hippocampal Sclerosis: Causes and Prevention

(2015) Matthew Walker   SEMINARS IN NEUROLOGY

Reassessing Models of Basal Ganglia Function and Dysfunction

(2014) Alexandra B. Nelson et al.   Annual Review of Neuroscience

Extratemporal lobe circuits in temporal lobe epilepsy

(2014) Edward H. Bertram   EPILEPSY & BEHAVIOR

Sex dimorphism in seizure-controlling networks

(2014) Fillippo Sean Giorgi et al.   NEUROBIOLOGY OF DISEASE

Intrasubthalamic cell transplants for epilepsy therapy

(2013) Manuela Gernert   NEUROREPORT

Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat

(2013) S. Bröer et al.   NEUROSCIENCE

Locally Applied Valproate Enhances Survival in Rats after Neocortical Treatment with Tetanus Toxin and Cobalt Chloride

(2013) Dirk-Matthias Altenmüller et al.   Biomed Research International

Novel methods of antiepileptic drug delivery — Polymer-based implants

(2012) Amy J. Halliday et al.   ADVANCED DRUG DELIVERY REVIEWS

Autoradiographic evidence for the transmeningeal diffusion of muscimol into the neocortex in rats

(2012) Nandor Ludvig et al.   BRAIN RESEARCH

Anticonvulsant Effects by Bilateral and Unilateral Transplantation of GABA-Producing Cells into the Subthalamic Nucleus in an Acute Seizure Model

(2012) Annelie Handreck et al.   CELL TRANSPLANTATION

Changing Views of Basal Ganglia Circuits and Circuit Disorders

(2012) Mahlon DeLong et al.   CLINICAL EEG AND NEUROSCIENCE

Do the basal ganglia inhibit seizure activity in temporal lobe epilepsy?

(2012) Ivan Rektor et al.   EPILEPSY & BEHAVIOR

An Implantable Closedloop Asynchronous Drug Delivery System for the Treatment of Refractory Epilepsy

(2012) M. T. Salam et al.   IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING

Levetiracetam-loaded biodegradable polymer implants in the tetanus toxin model of temporal lobe epilepsy in rats

(2012) Amy J. Halliday et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Long-term behavioral, electrophysiological, and neurochemical monitoring of the safety of an experimental antiepileptic implant, the muscimol-delivering Subdural Pharmacotherapy Device in monkeys

(2012) Nandor Ludvig et al.   JOURNAL OF NEUROSURGERY

Topography of dyskinesias and torticollis evoked by inhibition of substantia nigra pars reticulata

(2012) David Dybdal et al.   MOVEMENT DISORDERS

Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model

(2012) Sonja Bröer et al.   NEUROBIOLOGY OF DISEASE

Transmeningeal muscimol can prevent focal EEG seizures in the rat neocortex without stopping multineuronal activity in the treated area

(2011) Nandor Ludvig et al.   BRAIN RESEARCH

Blood-Brain Barrier P450 Enzymes and Multidrug Transporters in Drug Resistance: A Synergistic Role in Neurological Diseases

(2011) Chaitali Ghosh et al.   CURRENT DRUG METABOLISM

The Anticonvulsant Response to Valproate in Kindled Rats Is Correlated with Its Effect on Neuronal Firing in the Substantia Nigra Pars Reticulata: A New Mechanism of Pharmacoresistance

(2011) K. Tollner et al.   JOURNAL OF NEUROSCIENCE

An implantable triple-function device for local drug delivery, cerebrospinal fluid removal and EEG recording in the cranial subdural/subarachnoid space of primates

(2011) Nandor Ludvig et al.   JOURNAL OF NEUROSCIENCE METHODS

A new hypothesis of drug refractory epilepsy: Neural network hypothesis

(2011) Min Fang et al.   MEDICAL HYPOTHESES

Converging PET and fMRI evidence for a common area involved in human focal epilepsies

(2011) H. Laufs et al.   NEUROLOGY

Periodic transmeningeal muscimol maintains its antiepileptic efficacy over three weeks without inducing tolerance, in rats

(2011) Hai M. Tang et al.   NEUROSCIENCE LETTERS

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

(2011) Wolfgang Löscher   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Insights into the novel three ‘D's of epilepsy treatment: drugs, delivery systems and devices

(2010) Shadab A. Pathan et al.   DRUG DISCOVERY TODAY

Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures

(2010) Annelies Van Dycke et al.   EPILEPSIA

Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus

(2010) Simone Bittencourt et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Interactions between the midbrain superior colliculus and the basal ganglia

(2010) Peter Redgrave   Frontiers in Neuroanatomy

Cortical and subcortical networks in human secondarily generalized tonic–clonic seizures

(2009) H. Blumenfeld et al.   BRAIN

Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

(2009) Patrick Kwan et al.   EPILEPSIA

Preclinical assessment of proconvulsant drug activity and its relevance for predicting adverse events in humans

(2009) Wolfgang Löscher   EUROPEAN JOURNAL OF PHARMACOLOGY

Antiepileptic effects of silk-polymer based adenosine release in kindled rats

(2009) Cory Szybala et al.   EXPERIMENTAL NEUROLOGY

Image-guided convection-enhanced delivery of muscimol to the primate brain

(2009) John D. Heiss et al.   JOURNAL OF NEUROSURGERY

Kindling as a model of temporal lobe epilepsy induces bilateral changes in spontaneous striatal activity

(2009) Saskia Kücker et al.   NEUROBIOLOGY OF DISEASE

Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats

(2009) Shirn L. Baptiste et al.   NEUROSCIENCE LETTERS

Intraventricular and intracerebral delivery of anti-epileptic drugs in the kindling model

(2009) Juan A. Barcia et al.   Neurotherapeutics

Nanotechnology for delivery of drugs to the brain for epilepsy

(2009) Margaret F. Bennewitz et al.   Neurotherapeutics

Convection-enhanced delivery in the treatment of epilepsy

(2009) Michael A. Rogawski   Neurotherapeutics

Continuous bilateral infusion of GABA in the dorsomedian nucleus of the thalamus elevates the generalized seizure threshold in amygdala-kindled rats

(2009) José M. Gallego et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Silk polymer-based adenosine release: Therapeutic potential for epilepsy

(2008) Andrew Wilz et al.   BIOMATERIALS

Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: Therapeutic implications

(2008) Nandor Ludvig et al.   EPILEPSIA

Effects of subdural application of lidocaine in patients with focal epilepsy

(2008) Deepak Madhavan et al.   EPILEPSY RESEARCH

Habenula: Crossroad between the Basal Ganglia and the Limbic System

(2008) O. Hikosaka et al.   JOURNAL OF NEUROSCIENCE

Cell and gene therapies in epilepsy – promising avenues or blind alleys?

(2008) Wolfgang Löscher et al.   TRENDS IN NEUROSCIENCES

Technology Insight: neuroengineering and epilepsy—designing devices for seizure control

(2008) William C Stacey et al.   Nature clinical practice. Neurology

Multiple roles of midline dorsal thalamic nuclei in induction and spread of limbic seizures

(2007) Edward H. Bertram et al.   EPILEPSIA