Review
Pharmacology & Pharmacy
Mahfoozur Rahman, Waleed H. Almalki, Saad Alghamdi, Khalid S. Alharbi, Habibullah Khalilullah, Md Habban Akhter, Amit K. Keshari, Nisha Sharma, Tanuja Singh, Kriti Soni, Abdul Hafeez, Sarwar Beg
Summary: The development of pharmaceutical drug products for disease treatment is crucial, leading to an increasing number of approvals by global regulatory agencies. Utilizing a quality-by-design approach, process analytical technology, and printing techniques can revolutionize healthcare applications and enhance pharmaceutical manufacturing efficiency.
DRUG DISCOVERY TODAY
(2021)
Article
Medicine, Research & Experimental
Zhenfeng Shi, Jifang Liu, Lei Tian, Jingyi Li, Yue Gao, Yue Xing, Wenjing Yan, Chenyu Hua, Xiaolin Xie, Chang Liu, Chengyuan Liang
Summary: This review summarizes the significance and application of diselenide bonds in redox responsive drug delivery systems (DDSs). It comprehensively reports the stimulation sensitivity of diselenide bonds and extensively discusses the potential and prospects for their application in next-generation anticancer drug treatment systems.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Louis Martin-Monier, Pierre-Luc Piveteau, Fabien Sorin
Summary: Soft electronics have attracted considerable interest due to their biomechanical compatibility. The study introduces the novel concept of periodic stretchable patterns combining multiple conductive materials to produce tailored responses, and demonstrates constant resistance-strain responses up to 50% elongation. Additionally, counterintuitive sinusoidal responses are achieved by integrating three materials, with potential applications in sensing and soft robotics.
Review
Biochemistry & Molecular Biology
Wanlin Lai, Dan Du, Lei Chen
Summary: This review explores the metabolomics of epilepsy and identifies potential biomarkers and metabolic pathways that can aid in the diagnosis, treatment, and prognosis of the disease. It provides a novel perspective for the identification of therapeutic targets for epilepsy.
NEUROCHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Xueni Wang, Qian Zhou, Xiaoning Li, Xia Gan, Peng Liu, Xiaotao Feng, Gang Fang, Yonghong Liu
Summary: Prostate cancer is a common cancer in elderly males. Drug therapies have made significant progress, but side effects remain a problem. Aptamer-drug delivery systems have potential to reduce side effects, but have not entered the market yet. Research has identified at least nine potential anti-prostate cancer aptamer-drug delivery systems, but further development is needed.
Article
Chemistry, Multidisciplinary
Neha Singh, Madhu Vinjamur, Mamata Mukhopadhyay
Summary: This study provides insights into the adsorptive drug loading process in silica aerogels from supercritical CO2. A new method for accurate measurement of drug loading is presented, which yields lower results compared to the prevalent method. Both methods correlate well with the Langmuir adsorption equation.
Review
Pharmacology & Pharmacy
Haishu Chen, Jinan Xu, Hanyuan Xu, Tiancheng Luo, Yihao Li, Ke Jiang, Yangping Shentu, Zhiqian Tong
Summary: Alzheimer's disease (AD) is the most common form of dementia, characterized by the accumulation of amyloid beta protein (Aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein. However, drugs targeting Aβ and tau have not shown satisfactory clinical efficacy, challenging the hypothesis that AD is solely caused by Aβ cascade. Recent research suggests that endogenous formaldehyde, which increases with age, plays a direct role in the aggregation of Aβ and phosphorylation of tau, providing a new target for AD therapy. Moreover, the accumulation of Aβ in the extracellular space (ECS) hampers interstitial fluid drainage, hindering the successful delivery of AD drugs.
Review
Chemistry, Medicinal
Simona Petroni, Irene Tagliaro, Carlo Antonini, Massimiliano D'Arienzo, Sara Fernanda Orsini, Joao F. Mano, Virginia Brancato, Joao Borges, Laura Cipolla
Summary: Chitosan is a marine-origin polysaccharide with diverse applications in various sectors. This review provides an overview of chitosan properties, chemical functionalization, and the innovative biomaterials derived from it. The focus is on the preparation of chitosan-based biomaterials and their use in the biomedical field, aiming to inspire further exploration and development of advanced biomedical devices. Selected works from the last 10 years will be considered.
Review
Chemistry, Multidisciplinary
Ya Cui, Hairui Li, Yaxin Li, Lixia Mao
Summary: By manipulating the composition and structure of nanomaterials, an immunomodulatory bone regeneration strategy can be achieved to accelerate osteogenesis. However, the lack of knowledge about the interaction between nanomaterials and the immune system has resulted in their underutilization in clinical trials.
NANOSCALE ADVANCES
(2022)
Article
Oncology
Yiran Yao, Xiang Gu, Xiaofang Xu, Shengfang Ge, Renbing Jia
Summary: This review focuses on the mechanism underlying RB1 mutation during oncogenesis, as well as potential clinical strategies for treating RB1-mutated cancers. The unsolved problems and prospects of RB1 mutation are also discussed.
Article
Engineering, Chemical
Yun Jia, Yu Zhang, Yaoguo Huang, Linlin Chen, Yali Zhang
Summary: Three novel acyl thiobenzamides were synthesized and used as flotation collectors for chalcopyrite. DFT calculations showed that TTBA had the strongest electron-donating ability and chemical reactivity, leading to the best collecting ability. Adsorption tests indicated that the adsorption process of TTBA onto chalcopyrite surfaces was endothermic-spontaneous with increased entropy.
MINERALS ENGINEERING
(2021)
Review
Polymer Science
H. P. S. Abdul Khalil, Kanchan Jha, Esam Bashir Yahya, Sandeep Panchal, Nidhi Patel, Arindam Garai, Soni Kumari, Mohammed Jameel
Summary: Soil fertilizers can significantly increase crop yields and improve plant health by providing essential nutrients to the soil. However, overuse or improper use of fertilizers can lead to soil degradation and damage ecosystems. Biopolymer aerogels show promise as an innovative solution to improve the efficiency and effectiveness of soil-fertilizer delivery systems, promoting sustainable farming practices.
Review
Instruments & Instrumentation
Pratiksha Patil, Shweta Nene, Saurabh Shah, Shashi Bala Singh, Saurabh Srivastava
Summary: Osteoarthritis is a disabling disorder with no definitive treatment. Oral administration and intra-articular injection have limitations, so there is a need for an alternative route. Topical delivery of nanocarriers through the skin could be a potential solution to overcome the drawbacks of intra-articular route.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Immunology
Mia Levite, Hadassa Goldberg
Summary: Autoimmune Epilepsy is a complex disorder involving autoimmune antibodies targeting glutamate receptors and inhibitory neurotransmitter receptors, leading to neuronal damage and behavioral issues. The findings suggest a potential link between autoimmune mechanisms and epilepsy pathogenesis, highlighting the importance of understanding the role of autoimmunity in neurological disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nguyen Thi Hai Yen, Jung-Hwa Oh, Nguyen Thi Van Anh, Quoc-Viet Le, Se-Myo Park, Young Jin Park, Yong-Soon Cho, Kyoung-Sik Moon, Huy Truong Nguyen, Jae-Gook Shin, Nguyen Phuoc Long, Dong Hyun
Summary: This study conducted multi-specimen molecular characterization in rats treated with different doses of indomethacin to investigate its toxicity mechanism. The results showed that a dose of 10 mg/kg of indomethacin caused significant metabolic changes and kidney injury. Analysis revealed an oxidant-antioxidant imbalance and dysfunction of mitochondria, which resulted in the dysregulation of metabolites and genes related to the kidney, as well as the suppression of amino acid and fatty acid metabolism. These findings provide insights into the mechanism of indomethacin toxicity and suggest potential targets for reducing its toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
Farhan Ahmad, Aisha Kamal, Ananya Singh, Farha Ashfaque, Saud Alamri, Manzer H. Siddiqui
Summary: This study evaluated the effect of seed priming with salicylic acid (SA) on reducing the adverse effects of salt stress in pea seedlings. The results showed that seed priming with SA alleviated the negative impact of salinity on overall plant performance, including growth and photosynthetic attributes. SA achieved this by inducing enzymatic and non-enzymatic antioxidant systems, promoting soluble sugar and proline accumulation, and regulating ion homeostasis. Seed priming with SA could be a promising approach for cultivating salt-tolerant plants.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Review
Environmental Sciences
Sima Singh, Arshid Numan, Dinesh Sharma, Rahul Shukla, Amit Alexander, Gaurav Kumar Jain, Farhan Jalees Ahmad, Prashant Kesharwani
Summary: The outbreak of the COVID-19 pandemic in 2019 and 2020 has led to a new era of communicable infectious diseases, with the emergence of Hantavirus infection posing a new public health emergency. Hantavirus, a zoonotic pathogen, causes two major clinical manifestations - HFRS and HCPS. Despite the lack of effective treatments or vaccines, public awareness and precautionary measures can help reduce the spread of the virus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Biochemical Research Methods
S. M. Kawish, Abdul Qadir, Suma Saad, Sarwar Beg, Gaurav K. Jain, Mohd Aqil, Amer M. Alanazi, Azmat Ali Khan, Md Abdur Rashid, Rehan A. Rab, Waleed H. Almalki, Farhan J. Ahmad
Summary: A cost-effective, reliable, and rapid HPTLC method was developed for estimating GLA in borage oil, utilizing aluminum plates precoated with silica gel as the stationary phase and a hexane:toulene:glacial acetic acid mixture as the mobile phase. The method showed well-resolved spots for GLA and was validated for parameters like linearity, accuracy, specificity, and precision. The method demonstrated high sensitivity for GLA estimation in herbal oil samples and formulations.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Mansi Budhiraja, Sobiya Zafar, Sohail Akhter, Majed Alrobaian, Md Abdur Rashid, Md. Abul Barkat, Sarwar Beg, Farhan J. Ahmad
Summary: This study developed a combinational drug delivery system by embedding mupirocin-loaded chitosan microspheres in a collagen scaffold containing Piper betle extract, aiming to improve wound healing. The results showed that this method effectively promoted wound healing and exhibited good antibacterial effects.
Article
Engineering, Chemical
Muzaffar Iqbal, Mohammad Raish, Ajaz Ahmad, Essam A. Ali, Yousef A. Bin Jardan, Mushtaq A. Ansari, Mudassar Shahid, Abdul Ahad, Khalid M. Alkharfy, Fahad I. Al-Jenoobi
Summary: The study found that when Ibrutinib interacts with Sinapic acid, it may influence the pharmacokinetics of Ibrutinib and result in increased bioavailability. This may be due to the inhibition of IBR metabolism in the liver and intestines by SA.
Review
Biochemistry & Molecular Biology
Syed M. Kawish, Shwetakshi Sharma, Waleed H. Almalki, Saad Alghamdi, Obaid Afzal, Imran Kazmi, Abdulmalik S. A. Altamimi, Fahad A. Al-Abbasi, Sarwar Beg, Farhan J. Ahmad
Summary: The pharmaceutical industry is advancing towards personalized medicine through innovation in drug development. Three-dimensional printing technology has enabled the manufacturing of personalized dosage forms, opening up new possibilities for discovering compounds and technologies.
CURRENT DRUG METABOLISM
(2022)
Article
Food Science & Technology
Sarushi Rastogi, Vinita Kumari, Vasudha Sharma, Farhan Jalees Ahmad
Summary: A colorimetric method was developed for visual detection of oxytocin in bottle gourd. The method showed high sensitivity and a quick reaction time, allowing for accurate screening of oxytocin.
FOOD ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Rehan A. Rub, Sagar Suman Panda, Sunil K. Panda, Waleed H. Almalki, Majed Alrobaian, Abdul Hafeez, Mahfoozur Rahman, Sarwar Beg, Asgar Ali, Farhan J. Ahmed
Summary: The research focuses on developing an analytical method for estimating aripiprazole in rat plasma using ultra-performance liquid chromatography coupled with tandem mass spectrometry. Propranolol was chosen as the internal standard for maximum recovery of the drug from rat plasma during pharmacokinetic evaluation.
SEPARATION SCIENCE PLUS
(2022)
Article
Engineering, Biomedical
Saman Fatima, Mubashshir Ali, Syed Naved Quadri, Sarwar Beg, M. Samim, Suhel Parvez, Malik Zainul Abdin, Prashant Mishra, Farhan Jalees Ahmad
Summary: The study reported the use of nanoparticles to enhance the targeting and bioavailability of ropinirole hydrochloride for the treatment of ischemic stroke. The nanoparticles showed improved therapeutic effects and reduced unwanted toxicities. Additionally, they were able to attenuate ischemic injury and restore neurological and behavioral deficits.
Editorial Material
Biochemistry & Molecular Biology
Md. Abul Barkat, Sarwar Beg, Farhan J. Ahmad
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
S. M. Kawish, Nazeer Hasan, Sarwar Beg, Abdul Qadir, Gaurav K. Jain, Mohd Aqil, Farhan J. Ahmad
Summary: In this study, a novel docetaxel-nanoemulsion was developed to improve therapeutic effectiveness and reduce side effects through targeted delivery. The optimized nanoemulsion demonstrated excellent characteristics in terms of drug encapsulation, drug release kinetics, and in vivo pharmacokinetics.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Instruments & Instrumentation
Pavitra Solanki, Mohd Danish Ansari, Mohd Iqbal Alam, Mohd Aqil, Farhan J. Ahmad, Yasmin Sultana
Summary: This study developed an orally effective nanoformulation of disodium pamidronate for the treatment of osteoporosis. Through rational design and optimization, a commercially potential self nano-emulsifying drug delivery system (SNEDDS) was developed, which showed improved oral bioavailability and enhanced anti-osteoporotic activity. The study provided significant achievements in the treatment of postmenopausal osteoporosis and may lead to the use of nanotherapeutic-driven emerging biodegradable carriers-based drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Farhan Ahmad, Shalini Singh, Niraj Kumari
Summary: Spontaneous regression (SR) is relatively rare in non-small-cell lung cancer, especially with adenocarcinoma histology. Various mechanisms have been postulated, but the exact underlying mechanism is still uncertain.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Arif Nadaf, Akash Gupta, Nazeer Hasan, Fauziya, Shadaan Ahmad, Prashant Kesharwani, Farhan J. Ahmad
Summary: Electrospinning is a versatile technique for generating ultrathin fibers, and this review provides a comprehensive overview of electrospinning and non-electrospinning processes, their setup, fabrication process, components, and applications. The review covers the characteristics of nanofibers, materials required for their production, and the diverse applications they have in various fields. It also discusses the challenges and future prospects of nanofiber development.
Article
Polymer Science
Mohammad Zubair Ahmed, Anshul Gupta, Musarrat Husain Warsi, Ahmed M. Abdelhaleem Ali, Nazeer Hasan, Farhan J. Ahmad, Ameeduzzafar Zafar, Gaurav K. Jain
Summary: Vitamin D deficiency is prevalent among nearly 50% of the global population, and this study developed a vitamin D oil-in-water nanoemulsion incorporated in edible gummies to enhance bioavailability and stability. The nanoemulsion prevented degradation of vitamin D and retained its activity over 15 days. The vitamin D gummies formulated with the nanoemulsion had optimal hardness and maintained taste and acceptance over 45 days of storage. This study highlights the potential of nanoemulsions to improve the delivery and effectiveness of vitamin D.
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
