Article
Neurosciences
Oliver C. Kiersnowski, Gavin P. Winston, Lorenzo Caciagli, Emma Biondetti, Maha Elbadri, Sarah Buck, John S. Duncan, John S. Thornton, Karin Shmueli, Sjoerd B. Vos
Summary: Using quantitative susceptibility mapping (QSM) and transverse relaxation rate (R2*), we investigated brain alterations in patients with temporal lobe epilepsy (TLE) compared to healthy controls (HC). We found significant changes in susceptibility and R2* in various brain regions, indicating selective loss of neurons and iron redistribution in the hippocampi, increased iron content in the thalamus and putamen, and correlations with disease severity and cognitive test scores.
HUMAN BRAIN MAPPING
(2023)
Article
Geriatrics & Gerontology
Jiale Hou, Haoyue Zhu, Ling Xiao, Charlie Weige Zhao, Guang Liao, Yongxiang Tang, Li Feng
Summary: The objective of this study was to investigate the cerebral metabolic changes in patients with temporal lobe epilepsy and impaired awareness seizures (TLE-IAS). The results showed abnormal cortical-subcortical metabolism in TLE-IAS patients, which correlated with the altered consciousness. These findings have important implications for guiding clinical treatments and improving the quality of life in TLE patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Genetics & Heredity
Yishu Wang, Jing Peng, Shuwei Bai, Haojun Yu, Hong He, Chunxiang Fan, Yong Hao, Yangtai Guan
Summary: Temporal lobe epilepsy (TLE), the most common form of refractory epilepsy in adults, may require surgery to alleviate seizures. Research suggests that a mutation in the PIK3R2 gene may play a significant role in the development of TLE.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Valerie J. Sydnor, Matthew Cieslak, Romain Duprat, Joseph Deluisi, Matthew W. Flounders, Hannah Long, Morgan Scully, Nicholas L. Balderston, Yvette Sheline, Dani S. Bassett, Theodore D. Satterthwaite, Desmond J. Oathes
Summary: The amygdala processes valenced stimuli and influences emotion. This study found that transcranial magnetic stimulation (TMS) can indirectly change amygdala activity when applied to ventrolateral prefrontal cortex (vIPFC). TMS stimulation of vIPFC was associated with acute and focal modulations of amygdala activity. Higher fiber density in the vIPFC-amygdala white matter pathway was also related to larger TMS-induced changes in the amygdala, indicating the importance of this pathway for cortical-subcortical communication.
Article
Medicine, General & Internal
Pablo Cabezudo-Garcia, Nicolas L. Ciano-Petersen, Natalia Mena-Vazquez, Jesus Ortega-Pinazo, Maria J. Postigo-Pozo, Guillermina Garcia-Martin, Helena Antoli-Martinez, Violeta Sanchez-Sanchez, Pablo Quiroga-Subirana, Pedro J. Serrano-Castro, Guillermo Estivill-Torrus
Summary: The study revealed a high prevalence of neural autoantibodies in adult patients with drug-resistant temporal lobe epilepsy of unknown etiology, indicating a possible autoimmune mechanism. The presence of bitemporal, independent, interictal epileptiform discharges and a history of status epilepticus may serve as markers for autoimmune-associated epilepsy in drug-resistant temporal lobe epilepsy of unknown etiology. Further validation of the proposed ARTE score in larger independent cohorts is warranted.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Nadim Jaafar, Amar Bhatt, Alexandra Eid, Mohamad Z. Koubeissi
Summary: Some surgical failures after temporal lobe epilepsy surgery may be caused by the presence of extratemporal epileptogenic zones, particularly in the medial parietal lobe. Seizures originating from this area may not cause obvious symptoms before spreading to the temporal lobe.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neuroimaging
Alfredo Lucas, Sofia Mouchtaris, Eli J. Cornblath, Nishant Sinha, Lorenzo Caciagli, Peter Hadar, James J. Gugger, Sandhitsu Das, Joel M. Stein, Kathryn A. Davis
Summary: Expansion of functional gradients (SFGs) is characteristic of temporal lobe epilepsy (TLE), and there are differences in subcortical functional gradients between left (L)-TLE and right (R)-TLE, driven by connectivity changes in the ipsilateral hippocampus.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin, Chun Kee Chung
Summary: Selective resection in mesial temporal lobe epilepsy surgery has been shown to effectively preserve postoperative memory function, with specific areas of resection correlating with memory decline. This suggests the importance of selective resection to protect memory function in temporal lobe surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Valeri Borger, Motaz Hamed, Julia Taube, Gulsah Aydin, Inja Ilic, Matthias Schneider, Patrick Schuss, Erdem Guresir, Albert Becker, Christoph Helmstaedter, Christian E. Elger, Hartmut Vatter
Summary: Temporal lobe epilepsy (TLE) is a common form of epilepsy, and about 30% of patients have drug-resistant seizures. This study evaluated the seizure outcomes of patients with drug-refractory TLE who underwent resective temporal lobe surgery (rTLS), finding that the lack of MRI lesions and placement of depth electrodes before surgery were associated with unfavorable postsurgical seizure outcomes.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Xi Zhang, Guojun Zhang, Tao Yu, Cuiping Xu, Jin Zhu, Xiaoming Yan, Kai Ma, Runshi Gao
Summary: This study analyzed the surgical outcomes of patients with temporal lobe epilepsy (TLE) who underwent temporal and insular SEEG recordings. The findings suggest that insular involvement may be associated with failed anterior temporal lobectomy (ATL) and poorer seizure outcomes. The study also identified temporal-insular spreading time (TIST) as an independent predictor of postoperative seizure-free outcomes in these patients.
Article
Veterinary Sciences
Akos Pakozdy, Peter Halasz, Andrea Klang, Borbala A. Loerincz, Martin J. Schmidt, Ursula Glantschnigg-Eisl, Sophie Binks
Summary: This article summarizes the attention given to feline temporal lobe epilepsy (TLE) in recent years, stating that epileptic discharges in certain parts of the temporal lobe result in similar symptoms, justifying their grouping under one name. Feline TLE patients often exhibit histopathological changes in the hippocampus. The article aims to not only summarize the clinical features and possible etiology, but also to classify TLE within the veterinary epilepsy classification.
VETERINARY JOURNAL
(2023)
Article
Neurosciences
Liping Pan, Yakun Wu, Jie Bao, Dandan Guo, Xin Zhang, Jiajing Wang, Meili Deng, Peiran Yu, Gaoxu Wei, Lulin Zhang, Xiao Qin, Yijun Song
Summary: The aim of this study was to investigate the alterations in neural networks during working memory encoding in patients with temporal lobe epilepsy (TLE). The results showed that functional connectivity strength decreased, and the theta network was altered in TLE patients with working memory deficits. This suggests that the theta network may serve as a sensitive measure of cognitive impairment and predict cognitive outcomes in TLE patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Yun Qin, Sipei Li, Dezhong Yao, Cheng Luo
Summary: In this study, abnormal connections in the subcortical-cortical pathway in IGE were examined using resting-state fMRI data, with a focus on the dynamics and causal relationship among these interactions. Key regions representing abnormal functional network connectivity in this circuit were identified as the thalamus and precuneus. The results also indicated a causal effect of the connectivity between the precuneus and adjacent regions on the dysfunction of the thalamocortical circuit, while the connection between the striatum and thalamus played a modulatory role in epilepsy.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ivan Ignacio-Mejia, Itzel Jatziri Contreras-Garcia, Julieta Griselda Mendoza-Torreblanca, Omar Noel Medina-Campos, Jose Pedraza-Chaverri, Mercedes Edna Garcia-Cruz, Antonio Romo-Mancillas, Saul Gomez-Manzo, Cindy Bandala, Maria Elena Sanchez-Mendoza, Luz Adriana Pichardo-Macias, Noemi Cardenas-Rodriguez
Summary: Epilepsy is a neurological disorder associated with oxidative stress. Some antiseizure drugs, including levetiracetam, have been found to have neuroprotective and antioxidant properties. This study evaluated the effects of levetiracetam on the oxidant-antioxidant status in the hippocampus of rats with temporal lobe epilepsy (TLE). The results showed that levetiracetam increased antioxidant enzyme activity, reduced hydrogen peroxide levels, and demonstrated scavenging activity against hydroxyl radicals.
Article
Clinical Neurology
Yuanzhi Xu, Ahmed Mohyeldin, Maximiliano Alberto Nunez, Ayoze Doniz-Gonzalez, Vera Vigo, Aaron A. Cohen-Gadol, Juan C. Fernandez-Miranda
Summary: The authors investigated the microvascular anatomy of the hippocampus and its implications for medial temporal tumor surgery, revealing the anatomical variability of the arterial supply and venous drainage of the hippocampus. The study found rich anastomoses between hippocampal arteries and highlighted the importance of understanding the vascular variability and network of the hippocampus for surgery in this region, including anterior temporal lobectomy with amygdalohippocampectomy and transsylvian selective amygdalohippocampectomy.
JOURNAL OF NEUROSURGERY
(2021)
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)