Article
Clinical Neurology
Chenmin He, Cong Chen, Yuyu Yang, Lingli Hu, Bo Jin, Wenjie Ming, Zhongjin Wang, Yao Ding, Meiping Ding, Shuang Wang, Shan Wang
Summary: This study evaluated the clinical characteristics and prognostic significance of subclinical seizures in patients who underwent epilepsy surgery. The study found that the rate of subclinical seizures captured on intracranial EEG monitoring was higher than that on scalp EEG monitoring. Subclinical seizures detected on scalp EEG were associated with younger seizure onset, while those detected on intracranial EEG were associated with temporal lobe epilepsy and predicted surgical outcomes in focal epilepsy.
NEUROLOGY AND THERAPY
(2022)
Review
Clinical Neurology
Robert S. Fisher, Jayant N. Acharya, Fiona Mitchell Baumer, Jacqueline A. French, Pasquale Parisi, Jessica H. Solodar, Jerzy P. Szaflarski, Liu Lin Thio, Benjamin Tolchin, Arnold J. Wilkins, Dorothee Kasteleijn-Nolst Trenite
Summary: Light stimulation can trigger seizures in certain individuals, especially in young people and those with specific forms of epilepsy. Photosensitive seizures can coexist with spontaneous seizures and have a genetic component. The exact mechanisms of photosensitive seizures are still unclear, but specific triggers such as flashes or color changes can provoke seizures. Prevention strategies include avoiding triggers, covering one eye, keeping a safe distance from screens, reducing contrast, and taking certain antiseizure medications. Visually-induced seizures pose significant public health risks, requiring ongoing scientific research, regulation, and public education.
Article
Clinical Neurology
Richard A. Wennberg
Summary: This study reviewed 10,000 consecutive routine electroencephalography (EEG) studies and found that hyperventilation could reliably provoke focal seizures in patients with autoimmune encephalitis. All patients were diagnosed with autoimmune encephalitis, and five of them had voltage-gated potassium channel complex autoantibodies.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Ewan S. Nurse, Thilini Perera, Timothy Hannon, Victoria Wong, Kiran M. Fernandes, Mark J. Cook
Summary: This study aimed to measure the event capture rate of a home service in Australia using a shoulder-worn EEG device and telescopic pole-mounted camera. The results showed high event capture rates, with even higher rates when using video. Most patients had all events captured on camera.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Rodney Ogwang, Albert Ningwa, Pamela Akun, Paul Bangirana, Ronald Anguzu, Rajarshi Mazumder, Noriko Salamon, Oliver Johannes Henning, Charles R. Newton, Catherine Abbo, Amos Deogratius Mwaka, Kevin Marsh, Richard Idro
Summary: Research in northern Uganda shows that epilepsies associated with Onchocerca may have a broader clinical spectrum and brain imaging features, such as focal onset tonic-clonic seizures, cortical and cerebellar atrophy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Anna M. Bank, Ruben Kuzniecky, Robert C. Knowlton, Gregory D. Cascino, Graeme Jackson, Heath R. Pardoe
Summary: The study aimed to determine the frequency of MRI-identified potentially epileptogenic structural abnormalities in individuals with newly diagnosed focal epilepsy. The results showed that one in five patients may have causative MRI findings and an additional one in five patients have abnormalities of unknown relationship to epilepsy. This information is crucial for patient counseling, prognostication, and treatment planning.
Article
Clinical Neurology
John M. Bernabei, Nishant Sinha, T. Campbell Arnold, Erin Conrad, Ian Ong, Akash R. Pattnaik, Joel M. Stein, Russell T. Shinohara, Timothy H. Lucas, Dani S. Bassett, Kathryn A. Davis, Brian Litt
Summary: Bernabei et al. constructed an atlas of normative interictal intracranial EEG recordings and found that brain regions generating spikes and seizures have different patterns of activity and connectivity compared to the atlas. Comparing EEG recordings to the atlas can reliably identify abnormal regions and guide invasive treatment for epilepsy.
Article
Clinical Neurology
Magdalena Seethaler, Michael Lauseker, Katharina Ernst, Jan Remi, Christian Vollmar, Soheyl Noachtar, Elisabeth Kaufmann
Summary: The study revealed significantly longer seizure durations in cases of left-hemispheric seizure onset, especially in temporal lobe seizures. Seizures starting in the left hemisphere also showed prolonged duration when commencing during waking state, but not during sleep. Gender differences were observed, with a similar hemispheric difference in seizure duration found in female patients, but not in men.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Review
Neurosciences
Elena Dossi, Gilles Huberfeld
Summary: Epilepsy is characterized by abnormal neuronal activities, which have traditionally been attributed to a defect in inhibition and excessive excitation. However, recent findings suggest that GABAergic signaling is not impaired, but instead may contribute to seizure generation. This indicates the importance of GABAergic signaling in the onset of seizures.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biology
Syed Muhammad Usman, Shehzad Khalid, Sadaf Bashir
Summary: The research introduces a deep learning-based ensemble learning method that achieves high sensitivity and specificity in predicting epileptic seizures, while also reducing the anticipation time.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Jacopo Lanzone, Lorenzo Ricci, Mario Tombini, Marilisa Boscarino, Oriano Mecarelli, Patrizia Pulitano, Vincenzo Di Lazzaro, Giovanni Assenza
Summary: This study examined qEEG changes in patients with epilepsy receiving Perampanel (PER) as add-on therapy, revealing increased theta power but no significant alteration in EEG connectivity. Compared to healthy controls, patients showed differences in beta power and connectivity in delta and theta ranges. Alpha power may serve as a predictor of treatment response.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Simona Lattanzi, Giovanni De Maria, Eleonora Rosati, Giuseppe Didato, Valentina Chiesa, Federica Ranzato, Laura Canafoglia, Edward Cesnik, Francesca Anzellotti, Stefano Meletti, Giada Pauletto, Annacarmen Nilo, Emanuele Bartolini, Daniela Marino, Elena Tartara, Concetta Luisi, Paolo Bonanni, Alfonso Marrelli, David Stokelj, Filippo Dainese, Nicoletta Foschi, Claudia Cagnetti, Stefano Gazzina, Margherita Contento, Martina Biggi, Matteo Magliani, Roberta Di Giacomo, Chiara Pastori, Maria Paola Canevini, Elena Zambrelli, Giuseppe Billo, Marina Casazza, Elisa Fallica, Giuseppa Rosa, Fedele Dono, Rino Speranza, Cristina Cioclu, Anna Elisabetta Vaudano, Lorenzo Kiferle, Rosita Galli, Martina Guadagni, Carlo Andrea Galimberti, Benedetta Kassabian, Florinda Ferreri, Elisa Osanni, Roberta Ciuffini, Valeria Badioni, Simone Beretta
Summary: This study assessed the clinical response to add-on brivaracetam (BRV) in real-world practice and found that BRV improved seizure control in patients with focal epilepsy. Prior antiseizure medications and baseline monthly seizure frequency were independently associated with the primary endpoint.
Article
Behavioral Sciences
Udaya Seneviratne, Harry Christie, Wendyl D'Souza, Mark Cook
Summary: This study aimed to investigate the differences in focal semiologic features between generalized-onset bilateral tonic-clonic seizures (GBTCS) and focal-onset bilateral tonic-clonic seizures (FBTCS). The results revealed that head version, preceding automatisms, eye version, unilateral facial clonic activity, and mouth deviation were more frequent in FBTCS. Additionally, longer seizure duration favored FBTCS, while shorter time to head version from the ictal onset indicated GBTCS. Therefore, careful evaluation of semiology can help clinicians distinguish between FBTCS and GBTCS.
EPILEPSY & BEHAVIOR
(2022)
Article
Clinical Neurology
William O. Tatum, Lawrence J. Hirsch, Michael A. Gelfand, Emily K. Acton, W. Curt LaFrance, Robert B. Duckrow, David Chen, Andrew S. Blum, John Hixson, Joe Drazkowski, Selim Benbadis, Gregory D. Cascino
Summary: The study aimed to evaluate the quality of smartphone videos of neurologic events in adult epilepsy outpatients, finding that the majority of videos were suitable for clinical interpretation. Methods to improve video quality include encouraging patient interaction, adequate duration, and enlarged field of view during filming. While there were limitations in video quality, accuracy remained for the review of videos of epileptic seizures and psychogenic nonepileptic attacks.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Behavioral Sciences
Julie Bourgeois-Vionnet, Philippe Ryvlin, Mad-Helenie Elsensohn, Veronique Michel, Luc Valton, Philippe Derambure, Valerio Frazzini, Edouard Hirsch, Louis Maillard, Fabrice Bartolomei, Julien Biberon, Jerome Petit, Arnaud Biraben, Arielle Crespel, Pierre Thomas, Martine Lemesle-Martin, Philippe Convers, Mathilde Leclercq, Sebastien Boulogne, Pascal Roy, Sylvain Rheims
Summary: The study found that coffee consumption in patients with drug-resistant focal epilepsy was not associated with total seizure frequency, but was associated with FBTCS frequency, with lower FBTCS reported in patients with moderate coffee consumption. Multiple ordinal logistic regression showed a trend towards an association between coffee consumption and FBTCS frequency.
EPILEPSY & BEHAVIOR
(2022)
Article
Clinical Neurology
Jacqueline French, Victor Biton, Hina Dave, Kamil Detyniecki, Michael A. Gelfand, Hui Gong, Kore Liow, Terence J. O'Brien, Ahmed Sadek, Bree DiVentura, Brittany Reich, Jouko Isojarvi
Summary: This study demonstrated that Staccato alprazolam administered via a breath-actuated device can rapidly terminate epileptic seizures in hospitalized patients. The next step is to conduct a Phase 3 confirmatory study to further evaluate the efficacy and safety of Staccato alprazolam for seizure termination in an outpatient setting.
Article
Clinical Neurology
Jerzy P. P. Szaflarski, Orrin Devinsky, Merrick Lopez, Yong D. D. Park, Pilar Pichon Zentil, Anup D. D. Patel, Elizabeth A. A. Thiele, Robert T. T. Wechsler, Daniel Checketts, Farhad Sahebkar
Summary: The CBD expanded access program initiated in 2014 provided additional CBD treatment for patients with treatment-resistant epilepsies. The study showed that CBD treatment was effective in reducing seizure frequency and had an acceptable safety profile for long-term use in patients with treatment-resistant epilepsies.
Review
Clinical Neurology
Wesley T. Kerr, Stephane Auvin, Serge Van der Geyten, Christopher Kenney, Gerald Novak, Nathan B. Fountain, Caitlin Grzeskowiak, Jacqueline A. French
Summary: Well-designed placebo-controlled clinical trials are crucial for the development of new epilepsy treatments, but the design has remained unchanged for decades. Concerns have been raised by patients, clinicians, regulators, and innovators about the challenges of recruiting for trials, partly due to the static design of maintaining participants on add-on placebo for long periods of time when there are more therapy options available. Time-to-event trials, although having potential limitations, have been suggested as a promising mechanism to make trials more patient-friendly and reduce placebo exposure.
Article
Clinical Neurology
Wesley T. Kerr, Hai Chen, Mariana Figuera Losada, Christopher Cheng, Tiffany Liu, Jaqueline French
Summary: Selection criteria for clinical trials in medication-resistant epilepsy aim to ensure safety and limit variability, but it is increasingly difficult to recruit subjects. This study investigated the impact of these criteria on recruitment at an academic epilepsy center. The majority of patients were excluded due to insufficient seizure frequency. A small proportion of patients were eligible based on common criteria, but may not be representative of the overall population.
Article
Clinical Neurology
Robert J. Flamini, Anne M. Comi, E. Martina Bebin, Michael G. Chez, Gary Clark, Orrin Devinsky, Shaun A. Hussain, Paul D. Lyons, Anup D. Patel, Jillian L. Rosengard, Farhad Sahebkar, Eric Segal, Laurie Seltzer, Jerzy P. Szaflarski, Arie Weinstock
Summary: The CBD Expanded Access Program provided CBD treatment to patients with treatment-resistant epilepsy and showed a significant reduction in seizure frequency. CBD was well tolerated and effective in treating both convulsive and nonconvulsive seizure types. Controlled trials are needed to further confirm these findings.
Editorial Material
Clinical Neurology
Pavel Klein, Gregory L. Krauss, Bernhard J. Steinhoff, Orrin Devinsky, Michael R. Sperling
Summary: Despite the approval of numerous antiseizure medications (ASMs), a significant number of epilepsy patients still experience seizures. Two new ASMs, cenobamate and fenfluramine, have shown improved efficacy in reducing seizures with sustained results. However, these medications are underutilized, likely due to limited knowledge, access restrictions, and insufficient post-launch information about their efficacy and safety. Addressing these issues can improve seizure control and ultimately reduce morbidity and mortality in epilepsy patients.
Article
Clinical Neurology
P. Emanuela Voinescu, McKenna Kelly, Jacqueline A. French, Cynthia Harden, Anne Davis, Connie Lau, Alexa Ehlert, Stephanie Allien, Emma Osterhaus, Sarah Barnard, Rishabh Jain, Page B. Pennell
Summary: This study examined the occurrence and distribution of catamenial epilepsy patterns in women with epilepsy not receiving hormonal therapies. The results showed that out of 89 women enrolled, 23 were eligible for analysis, with 12 meeting criteria for catamenial epilepsy. App-based tracking proved to be a useful tool in determining catamenial patterns.
Article
Clinical Neurology
Joseph Sullivan, Lieven Lagae, J. Helen Cross, Orrin Devinsky, Renzo G. Guerrini, Kelly Knupp, Linda Laux, Marina Nikanorova, Tilman Polster, Dinesh Talwar, Berten Ceulemans, Rima M. Nabbout, Gail S. Farfel, Bradley R. Galer, Arnold Gammaitoni, Michael Lock, Anupam E. Agarwal, Ingrid Scheffer, FAiRE DS Study Grp
Summary: This study examined the safety and effectiveness of fenfluramine in treating convulsive seizures in patients with Dravet syndrome. The results showed that patients treated with fenfluramine had lower seizure frequency and longer interval between seizures compared to the placebo group. Common side effects of fenfluramine were observed, but no evidence of severe cardiac or vascular issues was found.
Article
Clinical Neurology
Wesley T. T. Kerr, Advith S. S. Reddy, Sung Hyun Seo, Neo Kok, William C. C. Stacey, John M. M. Stern, Page B. B. Pennell, Jacqueline A. A. French
Summary: This study aimed to assess the changes in recruitment and retention challenges in clinical trials for focal onset epilepsy over time. A systematic analysis of randomized clinical trials was conducted to evaluate changes in participant numbers, trial sites, and countries since 1990. The study also analyzed the proportion of participants who completed each trial phase and the reasons for early trial exit. The findings highlight increasing challenges with participant recruitment and retention, as well as an increasing placebo response, emphasizing the need for changes in clinical trial design.
Article
Clinical Neurology
Jacob Pellinen, Heath Pardoe, Stefan Sillau, Sarah Barnard, Jacqueline French, Robert Knowlton, Daniel D. Lowenstein, Gregory Cascino, Simon Glynn, Graeme Jackson, Jerzy Szaflarski, Chris J. Morrison, Kimford Meador, Ruben Kuzniecky, Human Epilepsy Project Investigators
Summary: This study found that people with newly treated focal epilepsy and learning difficulties have lower brain tissue volume to intracranial volume, suggesting that developmental factors are an important marker of neuroanatomical changes in focal epilepsy. There were also independent associations between brain volume, age, and sex in the study population.
Article
Clinical Neurology
Jonah Fox, Sarah Barnard, Shruti H. Agashe, Manisha G. Holmes, Barry Gidal, Pavel Klein, Bassel W. Abou-Khalil, Jacqueline French, Human Epilepsy Project Investigators
Summary: More than one third of patients with focal epilepsy remain on monotherapy with their initial prescribed ASM. Approximately three out of five patients transition to monotherapy with another ASM, while approximately two out of five end up on polytherapy. Patients stay on lamotrigine for a longer duration compared to levetiracetam when it is prescribed as the initial monotherapy.
Review
Clinical Neurology
Laura Gould, Victoria Delavale, Caitlin Plovnick, Thomas Wisniewski, Orrin Devinsky
Summary: Febrile seizures are associated with an increased risk of epilepsy and rare cases of sudden unexplained death. Mortality rates varied in different studies, with some reporting no deaths and others identifying a significant percentage of deaths associated with febrile seizures. Minor hippocampal histopathological anomalies were common in sudden deaths with or without a history of febrile seizures. Most electroencephalography (EEG) studies were normal, and neuroimaging studies suggested increased right hippocampal volumes. Longer-term prospective studies are needed to fully understand the outcomes of simple or brief complex febrile seizures.
Article
Pharmacology & Pharmacy
Jessica M. Barry, Jacqueline A. French, Page B. Pennell, Ashwin Karanam, Cynthia L. Harden, Angela K. Birnbaum
Summary: This study aims to investigate the complexity of maintaining seizure control with lamotrigine during pregnancy and evaluate the potential risks of different dosing scenarios. The results suggest that some dosing regimens may increase seizure risk or toxicity. Early clearance changes during pregnancy may require therapeutic drug monitoring to determine whether the patient belongs to the low clearance change group or the high clearance change group.
Article
Multidisciplinary Sciences
Rodrigo Ordonez Sierra, Lizeth Katherine Pedraza, Livia Barcsai, Andrea Pejin, Qun Li, Gabor Kozak, Yuichi Takeuchi, Anett J. Nagy, Magor L. Lorincz, Orrin Devinsky, Gyoergy Buzsaki, Antal Berenyi
Summary: Dysregulated fear reactions can be caused by maladaptive processing of trauma-related memories. By manipulating hippocampal SWRs and cortical oscillations, fear extinction can be enhanced in male rats. The modified fear memories become resistant to recall and do not spontaneously reemerge. This effect is mediated by D2 receptor signaling-induced synaptic remodeling in the basolateral amygdala. These findings demonstrate the potential of neuromodulation in augmenting extinction learning and provide a new avenue for anxiety disorder treatments.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Heather E. Olson, Sam Amin, Nadia Bahi-Buisson, Orrin Devinsky, Eric D. Marsh, Elia Pestana-Knight, Rajsekar R. Rajaraman, Alex A. Aimetti, Eva Rybak, Fanhui Kong, Ian Miller, Joseph Hulihan, Scott Demarest
Summary: This study reports the 2-year safety and clinical outcomes of ganaxolone treatment in patients with CDD. The results show that ganaxolone significantly reduces major motor seizure frequency and maintains its efficacy and safety over the long term.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
