Article
Endocrinology & Metabolism
Emmanuel O. Okwuofu, Gbenga E. Ogundepo, Abigail M. Akhigbemen, Akinpelu L. Abiola, Raymond I. Ozolua, Ighodaro Igbe, Ononiwu Chinazamoku
Summary: This study found that creatine has a mitigating effect on seizure symptoms in mice and also improves anxiety and depressive-like behaviors. These effects were observed from the 5th day of treatment onwards.
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Fatemeh Aghaie, Afsaneh Shemshaki, Mojgan Rajabi, Parisa Khatami, Abdolkarim Hosseini
Summary: The study demonstrates that rapamycin has significant effects in preventing memory impairment in epileptic rats, delaying the onset of seizures, and increasing the expression levels of Gabra1 and Pras40 genes.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Behavioral Sciences
Maria Luiza Motta Pollo, Christiane Gimenes, Luciene Covolan
Summary: This study compares the differences between males and females in terms of seizure severity, memory impairment, and neuronal damage using a chemical kindling model of epilepsy. The results show that male rats have higher seizure scores and more pronounced cell loss, while female rats exhibit more intense memory deficits.
EPILEPSY & BEHAVIOR
(2022)
Article
Endocrinology & Metabolism
Fatemeh Sadat Heydari, Mahmoud Gorji Valokola, Soghra Mehri, Khalil Abnous, Ali Roohbakhsh
Summary: This study investigated the role of TRPA1 in the treatment of epilepsy and found that the TRPA1 antagonist HC030031 can reduce the severity of seizures and prevent the upregulation of TRPA1 levels after seizure induction.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Lekha Saha, Puja Kumari, Kajal Rawat, Vipasha Gautam, Arushi Sandhu, Neha Singh, Alka Bhatia, Shalmoli Bhattacharya, V. R. Sinha, Amitava Chakrabarti
Summary: The study suggests that Berberine (BBR) nanoparticles have a promising effect in controlling seizures and alleviating pathologies and sequelae in the kindling model of epileptogenesis.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Adrian Bartoszek, Alicja Trzpil, Anna Kozub, Emilia Fornal
Summary: This study aimed to optimize the zebrafish larvae pentylenetetrazol-induced seizure model to investigate the interaction between caffeine and topiramate. An analytical method was developed to measure the levels of caffeine, topiramate, and its metabolite paraxanthine in zebrafish larvae. The results showed that caffeine and topiramate separately reduced the locomotor activity of zebrafish larvae but could not lower it to the control level. Co-administration of caffeine and topiramate at specific doses suppressed the activity to the control level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Artificial Intelligence
Lars Stumpp, Hugo Smets, Simone Vespa, Joaquin Cury, Pascal Doguet, Jean Delbeke, Antoine Nonclercq, Riem El Tahry
Summary: The study demonstrates the possibility of using vagus nerve electroneurogram for seizure detection, with successful development of metrics and a classifier for this purpose.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2021)
Article
Neurosciences
M. S. Shahpari, M. R. N. Namavar, L. K. D. Kamali Dolatabadi, H. A. Aligholi, M. E. Emamghoreishi
Summary: The study showed that SNpr plays a crucial role in seizure propagation, with differences in diameter and cell numbers observed between early and late-phase kindled groups. These findings indicate that SNpr is an important structure involved in the processes of epileptogenesis.
NEUROSCIENCE LETTERS
(2021)
Article
Endocrinology & Metabolism
Hongming Ye, Tong Cao, Qigang Shu, Yue Chen, Yongli Lu, Zhi He, Zicheng Li
Summary: The orexin receptor 1 (OX1R) plays a crucial role in mediating anxiety during drug withdrawal in opioid addicts. Inhibition of OX1R alleviates anxiety-like behaviors in abstinent mice, and the expression of OX1R is upregulated during morphine withdrawal.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Franco Diaz, Freddy Aguilar, Mario Wellmann, Andres Martorell, Camila Gonzalez-Arancibia, Lorena Chacana-Veliz, Ignacio Negron-Oyarzo, Andres E. Chavez, Marco Fuenzalida, Francisco Nualart, Ramon Sotomayor-Zarate, Christian Bonansco
Summary: Epilepsy is a chronic condition characterized by recurrent spontaneous seizures. The interaction between astrocytes and neurons has been suggested to play a role in epileptogenesis. This study used a mouse model to evaluate the interaction between astrocytes and synaptic function in epileptic brains. The findings suggest that astrocyte hyperactivity enhances excitatory synaptic transmission, thereby impacting the excitatory/inhibitory balance in the hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Bin Li, Leilei Chang, Xiaochun Peng
Summary: Orexin, mainly synthesized in the lateral hypothalamus/perifornical area, is implicated in feeding, sleep-wake cycles, and reward. Activation of OX2R in the NAc shell has been found to play a role in regulating acute stress-induced anxiety, suggesting OX2R antagonist as a potential treatment for anxiety disorders.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Patrick C. Milder, Agnes S. Zybura, Theodore R. Cummins, James A. Marrs
Summary: Approximately 30% of patients with epilepsy do not achieve adequate seizure control with current drugs and treatments, highlighting the need for more efficient screening methods. This study presents an optimized method using a zebrafish seizure model to screen anti-seizure drugs, comparing behavior and neural activity. The results show that EEG and GCaMP measurements largely correlate with behavior, providing a more comprehensive assessment of drug efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Fabio Cesar Tescarollo, Daniel Valdivia, Spencer Chen, Hai Sun
Summary: The kindling model has been widely used to study the neurobiology of temporal lobe epilepsy. In this study, researchers investigated the role of inhibitory signaling during the process of kindling using optogenetics. The results suggest that the hippocampus continues to undergo self-modifications during the rest period, potentially leading to the development of a mirror focus on the contralateral hippocampus.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Mukaddes Pala, Ismail Meral, Nilgun Pala Acikgoz, Senay Gorucu Yilmaz, Semra Karaca Okur, Seyma Acar, Yalcin Polat, Fahri Akbas
Summary: In this study, the effects of miR-342-p on epileptogenesis were analyzed using the PTZ model, and GRM2 was identified as its target gene. The results suggest that downregulation of miR-342-3p may contribute to the upregulation of GRM2 in the PTZ kindling model.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Endocrinology & Metabolism
Mohammad Sheibani, Maryam Shayan, Mina Khalilzadeh, Mehdi Ghasemi, Ahmad Reza Dehpour
Summary: The correlation between sleep and epilepsy has been debated among scientists for many years. Sleep is a recurring state of mind and body that involves alternations in brain electrical activities. Sleep disorders are associated with epilepsy, which affects the origin, suppression, and spread of seizures. Orexin, a neuropeptide involved in wakefulness, has bidirectional effects on sleep and epilepsy. Understanding the relationship between sleep, epilepsy, and orexin is important for developing potential therapeutic strategies.
Article
Public, Environmental & Occupational Health
Hamid Hakimi, Jafar Ahmadi, Alireza Vakilian, Ahmad Jamalizadeh, Zahra Kamyab, Mahya Mehran, Reza Malekzadeh, Hossein Poustchi, Sareh Eghtesad, Farimah Sardari, Mohammadreza Soleimani, Morteza Khademalhosseini, Mohammadreza Abolghasemi, Movahedeh Mohammadi, Tabandeh Sadeghi, Fatemeh Ayoobi, Mitra Abbasi, Maryam Mohamadi, Zahra Jalali, Ali Shamsizadeh, Ali Esmaeili-Nadimi
Summary: Rafsanjan is a unique city in Iran, known for its large human-made pistachio jungle and the second largest copper mine, as well as its location on the opium trade route. Concerns about health outcomes in this city led to the initiation of the Rafsanjan Cohort Study, which revealed a concerning prevalence of non-communicable disease risk factors. Further investigations and interventions are needed to address these health issues.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Neurosciences
Iman Fatemi, Abbas Abdollahi, Ali Shamsizadeh, Mohammad Allahtavakoli, Ali Roohbakhsh
Summary: The study suggests that striatal GPR55 is involved in the control of motor functions. However, considering the similar effects of GPR55 agonist and antagonist, it may be concluded that this receptor has a modulatory role in the control of motor deficits in an experimental model of Parkinson's disease.
ACTA NEUROPSYCHIATRICA
(2021)
Article
Cell Biology
Felor Biniazan, Asma Manzari-Tavakoli, Fahimeh Safaeinejad, Ali Moghimi, Farzad Rajaei, Hassan Niknejad
Summary: This study demonstrated the significant impact of BMP-4 and its inhibition on the differentiation of amnion-derived stem cells into ectodermal lineages, showing that hAECs can dedifferentiate into pluripotent cells. Activation and inhibition of BMP signaling were found to be key factors for ectodermal lineage differentiation.
CELL AND TISSUE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Daniel Ramandi, Mahmoud Elahdadi Salmani, Ali Moghimi, Taghi Lashkarbolouki, Masoud Fereidoni
Summary: This study demonstrates that upregulation of GLT-1 through ceftriaxone treatment can reduce glutamate levels, increase glutamine synthetase activity, and improve cognitive function in animal models of temporal lobe epilepsy. These findings suggest that astrocytic glutamate uptake plays a crucial role in hippocampal epileptogenesis and may provide a potential therapeutic target for rescuing cognitive deficits associated with epilepsy.
Article
Behavioral Sciences
Nosaibeh Riahi Zaniani, Ali Roohbakhsh, Ali Moghimi, Soghra Mehri
Summary: This study evaluates the neuroprotective effect of inhibiting Toll-like receptor 4 (TLR4), a prominent inflammatory axis, on the consequences of febrile seizures (FS) and adulthood. The results show that the inflammatory response is associated with increased cytokine levels and TLR4 expression, as well as memory deficits. Pretreatment with TAK-242, a specific TLR4 inhibitor, reduces inflammation and improves memory deficits.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Chemistry, Medicinal
Marzieh Hashemi, Mehdi Abbasnejad, Ali Moghimi, Saeed Esmaeili-Mahani, Mahnaz Zamyad, Abolfazl Heydari
Summary: Encapsulation of nifedipine (NIF) using water-soluble beta-cyclodextrin polymer (beta-CDP) was found to enhance the anticonvulsant effects of NIF in rats.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Neurosciences
Elnaz Azizi, Fatemeh Ayoobi, Ali Shamsizadeh, Amir Moghadam-Ahmadi, Seyed Ali Shafiei, Ali Reza Khoshdel, Mohammad Reza Mirzaei
Summary: The present study demonstrates that exposure to local extremely low-frequency magnetic fields (ELF-MFs) can modulate sleep and anxiety levels in male rats, potentially affecting the metabolism of oxalate and inducing sleepiness.
BASIC AND CLINICAL NEUROSCIENCE
(2022)
Article
Computer Science, Information Systems
Ali Akbari, Mohsen Nowkarizi, Reza Rostami, Ali Moghimi
Summary: The aim of this study was to identify the variables that can potentially affect information-seeking behaviour in mental health service providers. The findings showed that demographic, psychological, and skill level variables had significant effects on information-seeking behaviour. This is important for designers and librarians who seek to create novel or optimise existing physician-assisted systems.
JOURNAL OF INFORMATION SCIENCE
(2022)
Article
Neurosciences
Nazanin Mozafari, Jalal Hassanshahi, Hamid Ostadebrahimi, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Pak-Hashemi, Ayat Kaeidi
Summary: This study suggests that Achillea millefolium (Ach) extract has neuroprotective effects on chronic morphine-induced learning and memory impairment. The extract improved spatial learning and memory defects and reduced oxidative stress and apoptosis in the hippocampus CA1 region of morphine-treated animals.
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
(2022)
Article
Public, Environmental & Occupational Health
Tabandeh Sadeghi, Narjes Soltani, Zahra Jamali, Fatemeh Ayoobi, Parvin Khalili, Ali Shamsizadeh, Mostafa Nasirzadeh, Ali Esmaeili-Nadimi, Carlo La Vecchia, Zahra Jalali
Summary: This study aimed to determine the association of demographic and lifestyle parameters with overweight/obesity and abdominal obesity in a population of Iranian adults. The results recommend local public health strategies that promote training the society on the health benefits of avoiding alcohol, getting more physical exercise, and gaining more personal education on the health-threatening lifestyle.
Article
Pharmacology & Pharmacy
Maedeh Rahati Quchani, Elham Farmanesh, Asieh Esmaili, Ali Moghimi, Masoud Fereidoni, Saeed Rahati Quchani
Summary: This article explores the effects of Haplophyllum robustum hydroalcoholic extract on animals' behavior and electrocorticographic changes. The study reveals that the extract has an impact on electrocorticography (ECoG) and can induce changes in behavior through the intracerebroventricular administration of GABAA antagonists. Additionally, the study examines the effects of low doses of the extract on behavioral depression.
Article
Behavioral Sciences
Malihe Eskandari Torbaghan, Ali Moghimi, Hamid Reza Kobravi, Masoud Fereidoni, Imanollah Bigdeli
Summary: This study aimed to investigate the effect of estradiol on stress and effect of stress on spatial working memory during the menstrual cycle. The results showed that estradiol levels decreased in the late follicular, luteal, and early follicular phases, while galvanic skin response decreased after stress induction in all three phases. Spatial working memory diminished after stress induction in all three phases, but increased in the late follicular phase. Average power spectrum density in all frequency bands increased after stress induction in the frontal and prefrontal channels. Therefore, stress led to spatial working memory dysfunction, while estradiol improved spatial working memory performance in the late follicular phase.
BRAIN AND BEHAVIOR
(2023)
Article
Medicine, Research & Experimental
Faezeh Raeis Al Mohaddesin, Ali Moghimi, Javad Salehi Fadardi
Summary: This study is the first to apply evaluative conditioning training in OCD clinical samples, aiming to investigate the effect of this method on reducing disgust in patients with contamination-based OCD. It will also provide initial evidence for this emotion modulation method in the OCD population.
Article
Neurosciences
Mahmood Fotooh Estahbanati, Maryam Rezaeinasab, Soghra Akbari Chermahini, Hossein Mirzaeekia, Mahdieh Azin, Ali Shamsizadeh
Summary: This study found that involuntary tactile stimulation has a positive effect on individuals by improving their performance in verbal memory and creativity-convergent thinking.
BASIC AND CLINICAL NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Mohadeseh Mohammadi, Masoud Mobini, Fatemeh Mashayekhi, Mohammad Allahtavakoli, Ayat Kaeidi, Jalal Hassanshahi, Ali Shamsizadeh, Elham Hakimizadeh, Mahsa Hassanipour
Summary: The study demonstrated that conducting PC in female rats could prevent excessive CBF increase by tPA, reduce infarct volume and brain edema, protect BBB, alleviate neurobehavioral disorders, and decrease MMP-9 levels when combined with delayed tPA.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
