Article
Endocrinology & Metabolism
Fatemeh Sadat Heydari, Mahmoud Gorji Valokola, Soghra Mehri, Khalil Abnous, Ali Roohbakhsh
Summary: This study investigated the role of TRPA1 in the treatment of epilepsy and found that the TRPA1 antagonist HC030031 can reduce the severity of seizures and prevent the upregulation of TRPA1 levels after seizure induction.
METABOLIC BRAIN DISEASE
(2023)
Review
Geriatrics & Gerontology
Yilin Wang, Penghu Wei, Feng Yan, Yumin Luo, Guoguang Zhao
Summary: Epilepsy is a serious neurological disorder that can cause brain damage, and animal models help understand the mechanisms of epilepsy and select treatment drugs.
Article
Pharmacology & Pharmacy
Kai Zhong, Chengyu Qian, Rui Lyu, Xinyi Wang, Zhe Hu, Jie Yu, Jing Ma, Yilu Ye
Summary: Crocin has shown anti-epileptic effects in models of temporal lobe epilepsy, reducing seizure stages and duration, as well as suppressing generalized and spontaneous recurrent seizures. These effects may be mediated by its neuroprotective properties and modulation of inflammatory and neurotrophic factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Joe R. Hilton, Susannah R. Simpson, Emily R. Sherman, Will Raby-Smith, Keemia Azvine, Maite Arribas, Jiaqi Zhou, Serena Deiana, Bastian Hengerer, Emma N. Cahill
Summary: This study investigated whether recalling unpleasant memories in different contextual, olfactory, or auditory conditions would enhance anxiety-like behavior in the elevated plus maze. However, the data did not support the idea that memory recall could influence behavior in the elevated plus maze.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Chen-Ling Gan, Yulian Zou, Yongfang Xia, Tao Zhang, Dongmei Chen, Guihua Lan, Yingxue Mei, Long Wang, Xindong Shui, Li Hu, Hekun Liu, Tae Ho Lee
Summary: The study showed that the activity of DAPK1 increased in mice after convulsive seizures, but not its expression level. Suppressing DAPK1 expression through genetic knockout significantly reduced seizure phenotypes and the development of seizures. Pharmacological inhibition of DAPK1 activity demonstrated rapid antiepileptic effects in both acute and chronic epilepsy mouse models.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Premysl Jiruska, Dean Freestone, Vadym Gnatkovsky, Yujiang Wang
Summary: The theory of seizures beget seizures suggests that seizure activity can contribute to the progression of epilepsy. However, existing data and observations both support and oppose this theory. While recurrent seizures can cause negative changes in brain structure and function, other factors may also play a role in epilepsy progression.
Article
Endocrinology & Metabolism
Mohammad Sheibani, Maryam Shayan, Mina Khalilzadeh, Mehdi Ghasemi, Ahmad Reza Dehpour
Summary: The correlation between sleep and epilepsy has been debated among scientists for many years. Sleep is a recurring state of mind and body that involves alternations in brain electrical activities. Sleep disorders are associated with epilepsy, which affects the origin, suppression, and spread of seizures. Orexin, a neuropeptide involved in wakefulness, has bidirectional effects on sleep and epilepsy. Understanding the relationship between sleep, epilepsy, and orexin is important for developing potential therapeutic strategies.
Review
Clinical Neurology
Annie H. Roliz, Sanjeev Kothare
Summary: This review covers the mutual interactions between sleep and epilepsy, mechanisms of epileptogenesis in sleep, the relationship between sleep apnea and epilepsy, and potential strategies to treat seizures. Recent studies have emphasized the role of functional network systems underlying epileptiform activation in sleep in various epilepsy syndromes, and new treatment approaches including chronotherapy and seizure monitoring devices are being explored. Adenosine kinase and orexin receptor antagonists are promising new drug targets for seizure treatment.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Clinical Neurology
Gokce Ayhan Arslan, Serap Saygi, Ebru Bodur, Cigdem Cicek, F. Irsel Tezer
Summary: This study aimed to investigate the relationship between orexin and epilepsy. The study found that basal orexin levels were lower in epilepsy patients and the duration of awake seizures was shorter with increased orexin levels. Additionally, orexin levels after nocturnal seizure were higher in patients with left hemisphere onset or left temporal lobe lesions.
Article
Behavioral Sciences
Parker Knight, Ranjithkumar Chellian, Ryann Wilson, Azin Behnood-Rod, Stefany Panunzio, Adriaan W. Bruijnzeel
Summary: Female rats exhibit less anxiety-like behavior in the EPM and LOF tests, with sex differences present in almost all behavioral parameters. Additionally, there is a moderate positive correlation between parameters in the EPM and LOF tests.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Natalia Bonetti Bertagna, Paulla Giovanna Cabral dos Santos, Rafaella Misael Queiroz, Gustavo Juliate Damaceno Fernandes, Fabio Cardoso Cruz, Tarciso Tadeu Miguel
Summary: This study investigated the role of the dorsal (DH) and ventral (VH) hippocampus in anxiety-like behaviors in the elevated plus maze (EPM) by inhibiting these brain regions. Results showed that VH has a stronger modulatory effect on anxiety-like behaviors in EPM, and CRF and the cAMP/PKA pathway appear to regulate these effects.
PHARMACOLOGICAL REPORTS
(2021)
Review
Pharmacology & Pharmacy
Lia P. Iglesias, Lucas Bedeschi, Daniele C. Aguiar, Laila Asth, Fabricio A. Moreira
Summary: Delta(9)-THC and related cannabinoids have complex effects on anxiety-like behavior in humans and experimental animals. This study reviews previous research and finds that cannabinoids tend to reduce anxiety-like behavior at low doses, but can increase anxiety at high doses.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Zohabia Rehman, Talha Farooq, Sana Javaid, Waseem Ashraf, Muhammad Fawad Rasool, Noreen Samad, Maryam Tariq, Syed Muhammad Muneeb Anjum, Farzane Sivandzade, Faisal Alotaibi, Faleh Alqahtani, Imran Imran
Summary: The current study investigated the impact of combining levetiracetam and sodium selenite in a PTZ-induced kindling model. The results showed that levetiracetam treatment partially protected against epileptogenesis and improved behavioral deficits, while the combination of levetiracetam and sodium selenite had a better neuroprotective effect and improved behavioral outcomes. Furthermore, the combination therapy attenuated PTZ-induced oxidative stress. These findings suggest that combining sodium selenite with levetiracetam may be an effective strategy to address drug resistance and neuropsychiatric symptoms in epileptic patients.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Akbar Hajizadeh Moghaddam, Mohammad Amin Mashayekhpour, Mohaddeseh Abouhosseini Tabari
Summary: The study examined the anxiolytic activities of citral in mice and found that it exerted its effects through modulation of the GABA(A) and 5-HT1A receptors.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Willian Lazarini-Lopes, Gleice Kelli Silva-Cardoso, Christie Ramos Andrade Leite-Panissi, Norberto Garcia-Cairasco
Summary: This study investigated the impact of chronic epileptic seizures on anxiety-like behavior and TRPV1 channel expression in a genetic model of epilepsy. The results showed increased anxiety-like behavior in the model rats and alterations in TRPV1 expression in brain structures involved with epilepsy and anxiety comorbidity.
Article
Behavioral Sciences
Nosaibeh Riahi Zaniani, Ali Roohbakhsh, Ali Moghimi, Soghra Mehri
Summary: This study evaluates the neuroprotective effect of inhibiting Toll-like receptor 4 (TLR4), a prominent inflammatory axis, on the consequences of febrile seizures (FS) and adulthood. The results show that the inflammatory response is associated with increased cytokine levels and TLR4 expression, as well as memory deficits. Pretreatment with TAK-242, a specific TLR4 inhibitor, reduces inflammation and improves memory deficits.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Chemistry, Medicinal
Marzieh Hashemi, Mehdi Abbasnejad, Ali Moghimi, Saeed Esmaeili-Mahani, Mahnaz Zamyad, Abolfazl Heydari
Summary: Encapsulation of nifedipine (NIF) using water-soluble beta-cyclodextrin polymer (beta-CDP) was found to enhance the anticonvulsant effects of NIF in rats.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Neurosciences
Elnaz Azizi, Fatemeh Ayoobi, Ali Shamsizadeh, Amir Moghadam-Ahmadi, Seyed Ali Shafiei, Ali Reza Khoshdel, Mohammad Reza Mirzaei
Summary: The present study demonstrates that exposure to local extremely low-frequency magnetic fields (ELF-MFs) can modulate sleep and anxiety levels in male rats, potentially affecting the metabolism of oxalate and inducing sleepiness.
BASIC AND CLINICAL NEUROSCIENCE
(2022)
Article
Computer Science, Information Systems
Ali Akbari, Mohsen Nowkarizi, Reza Rostami, Ali Moghimi
Summary: The aim of this study was to identify the variables that can potentially affect information-seeking behaviour in mental health service providers. The findings showed that demographic, psychological, and skill level variables had significant effects on information-seeking behaviour. This is important for designers and librarians who seek to create novel or optimise existing physician-assisted systems.
JOURNAL OF INFORMATION SCIENCE
(2022)
Article
Neurosciences
Nazanin Mozafari, Jalal Hassanshahi, Hamid Ostadebrahimi, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Pak-Hashemi, Ayat Kaeidi
Summary: This study suggests that Achillea millefolium (Ach) extract has neuroprotective effects on chronic morphine-induced learning and memory impairment. The extract improved spatial learning and memory defects and reduced oxidative stress and apoptosis in the hippocampus CA1 region of morphine-treated animals.
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
(2022)
Article
Endocrinology & Metabolism
Fatemeh Sadat Heydari, Mahmoud Gorji Valokola, Soghra Mehri, Khalil Abnous, Ali Roohbakhsh
Summary: This study investigated the role of TRPA1 in the treatment of epilepsy and found that the TRPA1 antagonist HC030031 can reduce the severity of seizures and prevent the upregulation of TRPA1 levels after seizure induction.
METABOLIC BRAIN DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Tabandeh Sadeghi, Narjes Soltani, Zahra Jamali, Fatemeh Ayoobi, Parvin Khalili, Ali Shamsizadeh, Mostafa Nasirzadeh, Ali Esmaeili-Nadimi, Carlo La Vecchia, Zahra Jalali
Summary: This study aimed to determine the association of demographic and lifestyle parameters with overweight/obesity and abdominal obesity in a population of Iranian adults. The results recommend local public health strategies that promote training the society on the health benefits of avoiding alcohol, getting more physical exercise, and gaining more personal education on the health-threatening lifestyle.
Review
Pharmacology & Pharmacy
Mohaddeseh Sadat Alavi, Gholamreza Karimi, Hussein A. Ghanimi, Ali Roohbakhsh
Summary: Cholesterol is a vital component of the cell membrane that affects membrane properties and functions. Its metabolism in the brain is regulated by CYP46A1, which converts cholesterol to 24S-hydroxycholesterol for elimination. Studies suggest that changes in cholesterol levels may be associated with neurological diseases, and targeting CYP46A1 could be a therapeutic approach. Preclinical studies have investigated the role of CYP46A1 in various brain disorders and injuries, and a selective inhibitor called soticlestat has shown promising anti-seizure effects. Both activation and inhibition of CYP46A1 have therapeutic potential, as demonstrated by previous studies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Tahere Paseban, Mohaddeseh Sadat Alavi, Leila Etemad, Ali Roohbakhsh
Summary: Cholesterol homeostasis is crucial for normal brain function, and ABCA1 plays a significant role in regulating cholesterol efflux. ABCA1 is involved in various CNS disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, neuropathy, anxiety, depression, psychosis, epilepsy, stroke, brain ischemia, and trauma.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Pharmacology & Pharmacy
Maedeh Rahati Quchani, Elham Farmanesh, Asieh Esmaili, Ali Moghimi, Masoud Fereidoni, Saeed Rahati Quchani
Summary: This article explores the effects of Haplophyllum robustum hydroalcoholic extract on animals' behavior and electrocorticographic changes. The study reveals that the extract has an impact on electrocorticography (ECoG) and can induce changes in behavior through the intracerebroventricular administration of GABAA antagonists. Additionally, the study examines the effects of low doses of the extract on behavioral depression.
Article
Behavioral Sciences
Malihe Eskandari Torbaghan, Ali Moghimi, Hamid Reza Kobravi, Masoud Fereidoni, Imanollah Bigdeli
Summary: This study aimed to investigate the effect of estradiol on stress and effect of stress on spatial working memory during the menstrual cycle. The results showed that estradiol levels decreased in the late follicular, luteal, and early follicular phases, while galvanic skin response decreased after stress induction in all three phases. Spatial working memory diminished after stress induction in all three phases, but increased in the late follicular phase. Average power spectrum density in all frequency bands increased after stress induction in the frontal and prefrontal channels. Therefore, stress led to spatial working memory dysfunction, while estradiol improved spatial working memory performance in the late follicular phase.
BRAIN AND BEHAVIOR
(2023)
Review
Multidisciplinary Sciences
Firoozeh Abbasian, Mohaddeseh Sadat Alavi, Ali Roohbakhsh
Summary: Hypertension is a major risk factor for cardiovascular diseases and premature death in older adults. Lifestyle improvements, including consuming high amounts of fruits and vegetables, can reduce the risk of high blood pressure. Carotenoids, natural pigments with high pharmacological potential and safety, have antihypertensive properties and provide additional benefits to the cardiovascular system.
Article
Medicine, Research & Experimental
Faezeh Raeis Al Mohaddesin, Ali Moghimi, Javad Salehi Fadardi
Summary: This study is the first to apply evaluative conditioning training in OCD clinical samples, aiming to investigate the effect of this method on reducing disgust in patients with contamination-based OCD. It will also provide initial evidence for this emotion modulation method in the OCD population.
Article
Neurosciences
Mahmood Fotooh Estahbanati, Maryam Rezaeinasab, Soghra Akbari Chermahini, Hossein Mirzaeekia, Mahdieh Azin, Ali Shamsizadeh
Summary: This study found that involuntary tactile stimulation has a positive effect on individuals by improving their performance in verbal memory and creativity-convergent thinking.
BASIC AND CLINICAL NEUROSCIENCE
(2022)
