Article
Engineering, Electrical & Electronic
Uisub Shin, Cong Ding, Bingzhao Zhu, Yashwanth Vyza, Alix Trouillet, Emilie C. M. Revol, Stephanie P. Lacour, Mahsa Shoaran
Summary: This study proposes a highly scalable and versatile closed-loop neural interface system-on-chip (SoC) that can detect disease symptoms and restore lost functions in patients. The SoC achieves high accuracy and specificity in various experiments.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2022)
Review
Neurosciences
Martin G. Piazza, Gregory Varga, William Welch, Taylor J. Abel
Summary: Drug-resistant epilepsy has a negative impact on the quality of life and development of pediatric patients. Surgical treatments have evolved to include less invasive options such as neuromodulation techniques. Responsive neurostimulation is a closed-loop technology that allows for both treatment and data collection, with potential for internal assessment of treatment efficacy. This review describes the history and future directions of this technology.
Article
Clinical Neurology
Sharon Chiang, Ankit N. Khambhati, Emily T. Wang, Marina Vannucci, Edward F. Chang, Vikram R. Rao
Summary: The study reveals that the impact of brain neurostimulation on seizure frequency is state-dependent, with stimulation parameters showing varied effects in different seizure risk states. Higher charge density is associated with improved outcomes, while the effect of stimulation frequency depends on the initial seizure risk state.
Article
Neurosciences
Dimitrios Firfilionis, Frances Hutchings, Reza Tamadoni, Darren Walsh, Mark Turnbull, Enrique Escobedo-Cousin, Richard G. Bailey, Johannes Gausden, Aaliyah Patel, Dorian Haci, Yan Liu, Fiona E. N. LeBeau, Andrew Trevelyan, Timothy G. Constandinou, Anthony O'Neill, Marcus Kaiser, Patrick Degenaar, Andrew Jackson
Summary: Neuromodulation is an established treatment for neurological conditions, but improving the specificity of stimulation is necessary. Optogenetics offers promising research potential for optical stimulation of specific cell types. An open-source system is being developed for closed-loop optogenetic neuromodulation, allowing for flexibility and expansion in various neuroscientific applications.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Manu Hegde, Winston Chiong, Vikram R. Rao
Summary: Neurostimulation, particularly the Responsive Neurostimulation System, offers a new approach for treating drug-resistant epilepsy by continuously recording brain activity and providing stimulation to reduce seizure frequency. However, ethical and clinical challenges arise when using this technology, necessitating the development of a framework for understanding these issues.
Article
Clinical Neurology
Alfonso Fasano, Dawn Eliashiv, Susan T. Herman, Brian N. Lundstrom, Dara Polnerow, Jaimie M. Henderson, Robert S. Fisher
Summary: Deep brain stimulation of the anterior nuclei of thalamus (ANT-DBS) is effective for reducing seizures in patients with temporal or frontal epilepsy refractory to at least two medications. Motivations for therapy renewal upon battery depletion include reduced seizures, improved quality of life, and reduction of severe seizures. Stimulation parameters are mainly guided by magnetic resonance imaging and typically follow parameters similar to the SANTE study, with initial stimulation amplitudes in the 2-3 V or mA range.
Article
Engineering, Biomedical
Yuwei Wang, Hongrui Luo, Yang Chen, Zihao Jiao, Quan Sun, Lei Dong, Xinlei Chen, Xiaofei Wang, Hong Zhang
Summary: This study introduces an 8-channel closed-loop neuromodulation chipset with 2-level seizure classification. By activating the power-consuming fine classifier only when the patient's status is judged as suspected seizure, the overall power consumption is greatly reduced. The chipset demonstrates effective suppression of common-mode interference and stimulation artifacts, achieving high sensitivity in database testing.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2021)
Article
Engineering, Biomedical
Hao Fang, Yuxiao Yang
Summary: This study develops a robust adaptive neuromodulation algorithm to address performance issues of time-invariant controllers under real-time model uncertainty. Through theoretical analysis and Monte Carlo simulations, the algorithm accurately tracks brain state trajectories, enabling stable and robust control. The algorithm significantly outperforms state-of-the-art neuromodulation algorithms and has implications for future designs of closed-loop brain stimulation systems.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Clinical Neurology
Katerina Hristova, Cristina Martinez-Gonzalez, Thomas C. Watson, Neela K. Codadu, Kevan Hashemi, Peter C. Kind, Matthew F. Nolan, Alfredo Gonzalez-Sulser
Summary: This study evaluated a strategy of using optogenetic activation of medial septal GABAergic neurons to control seizures in temporal lobe epilepsy. The results showed that this method can reduce the duration of spontaneous seizures, while the number of medial septal GABAergic neurons and synaptic puncta in the hippocampus remained unchanged in epileptic conditions.
Article
Clinical Neurology
Tal Pal Attia, Daniel Crepeau, Vaclav Kremen, Mona Nasseri, Hari Guragain, Steven W. Steele, Vladimir Sladky, Petr Nejedly, Filip Mivalt, Jeffrey A. Herron, Matt Stead, Timothy Denison, Gregory A. Worrell, Benjamin H. Brinkmann
Summary: Epilepsy is a common neurological disorder affecting approximately 1% of the global population, with many patients continuing to have seizures despite treatment. The unpredictable nature of seizures and associated comorbidities significantly impact quality of life. Seizure predictions and long-term objective data are essential for optimizing treatment.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Diane J. Aum, Rebecca A. Reynolds, Sean McEvoy, Stuart Tomko, John Zempel, Jarod L. Roland, Matthew D. Smyth
Summary: This retrospective cohort study evaluated the surgical outcomes of corpus callosotomy (CC) in children with medically refractory epilepsy and found that both anterior and complete CC had similar seizure outcomes. Laser interstitial thermal therapy (LITT) was shown to be a less-invasive alternative to open craniotomy for CC, with lower blood loss, shorter hospital stays, and lower complication rates.
Article
Clinical Neurology
Kyoo Ho Cho, Ho-Joon Lee, Kyoung Heo, Sung Eun Kim, Dong Ah Lee, Kang Min Park
Summary: The study aimed to identify differences in intrinsic amygdala, hippocampal, or thalamic networks according to surgical outcomes in temporal lobe epilepsy patients with hippocampal sclerosis. The results revealed significant differences in intrinsic thalamic network between patients with poor and good surgical outcomes, suggesting a potential correlation between pre-operative intrinsic thalamic network and surgical outcomes in this patient population.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Yuichi Takeuchi, Mark Harangozo, Lizeth Pedraza, Tamas Foldi, Gabor Kozak, Qun Li, Antal Berenyi
Summary: The study demonstrates that closed-loop electrical stimulation of the medial septum can effectively terminate intrahippocampal seizures and suppress secondary generalization, emphasizing the importance of internally driven stimulus timing. By precisely activating medial septum GABAergic neurons, successful intervention in pathological oscillations was achieved, providing a new avenue for future clinical translation in other neurological and psychiatric disorders.
Article
Computer Science, Artificial Intelligence
Man Zhou, Jie Huang, Danfeng Hong, Feng Zhao, Chongyi Li, Jocelyn Chanussot
Summary: This paper proposes a closed-loop scheme that learns both the pan-sharpening and its corresponding degradation process simultaneously to regulate the solution space. A specific multiscale high-frequency texture extraction module is also designed to strengthen the algorithm. Experimental results demonstrate the effectiveness of the proposed algorithm.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Oncology
Rayhan A. Lal, Caitlin L. Maikawa, Dana Lewis, Sam W. Baker, Anton A. A. Smith, Gillie A. Roth, Emily C. Gale, Lyndsay M. Stapleton, Joseph L. Mann, Anthony C. Yu, Santiago Correa, Abigail K. Grosskopf, Celine S. Liong, Catherine M. Meis, Doreen Chan, Joseph P. Garner, David M. Maahs, Bruce A. Buckingham, Eric A. Appel
Summary: By comparing the AndroidAPS and Loop open-source AID systems in a pig model experiment, it was found that AndroidAPS performed better in terms of overall time-in-range and time spent in hypoglycemia, especially during overnight monitoring and lunchtime. The strategies used in the OpenAPS algorithm implemented in AndroidAPS for unannounced meals may lead to improved control in full closed loop systems.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Praveen Venkatesh, Daniel Sneider, Mohammed Danish, Nathaniel D. Sisterson, Naoir Zaher, Alexandra Urban, Pulkit Grover, R. Mark Richardson, Vasileios Kokkinos
Summary: This study developed a method to quantify ictal frequency modulation, aiming to optimize RNS stimulation systematically.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Clinical Neurology
Vasileios Kokkinos, Panagiotis Selviaridis, Ioannis Seimenis
Summary: This study examined how patient-related confounding factors affect language fMRI tasks, including feasibility, sensitivity, and anatomical specificity. The results suggest that the listening comprehension (LC) task may be the most feasible, less confounded, and efficiently lateralizing task in the clinical presurgical context.
Article
Clinical Neurology
Alexandra Astner-Rohracher, Georg Zimmermann, Tamir Avigdor, Chifaou Abdallah, Nirav Barot, Milan Brazdil, Irena Dolezalova, Jean Gotman, Jeffery Alan Hall, Kirsten Ikeda, Philippe Kahane, Gudrun Kalss, Vasileios Kokkinos, Markus Leitinger, Ioana Mindruta, Lorella Minotti, Mary Margaret Mizera, Irina Oane, Mark Richardson, Stephan U. Schuele, Eugen Trinka, Alexandra Urban, Benjamin Whatley, Francois Dubeau, Birgit Frauscher
Summary: The 5-SENSE score was developed and validated to predict the focality of the seizure-onset zone in SEEG. The score showed high specificity in predicting patients where SEEG is unlikely to identify a focal seizure-onset zone, helping clinicians reduce unnecessary invasive diagnostic burden on patients and overutilization of limited health care resources. Validation of the score showed a specificity of 76.0% and sensitivity of 52.3%.
Article
Clinical Neurology
Vasileios Kokkinos, Alexandra Urban, Birgit Frauscher, Mirela Simon, Helweh Hussein, Alan Bush, Ziv Williams, Anto Bagic, R. Mark Richardson
Summary: This study investigates the localization of barques across the hippocampal longitudinal axis. By analyzing data from 51 epilepsy patients, the study found that barques predominantly occur in the posterior hippocampus and are related to barque activity in the anterior hippocampus. Statistical parametric mapping confirmed significant differences in barque activity between the anterior and posterior hippocampus. The findings have important implications for the interpretation of intracranial electroencephalogram in epilepsy surgery evaluations involving the hippocampus.
CLINICAL NEUROPHYSIOLOGY
(2022)
Editorial Material
Neurosciences
Vasileios Kokkinos, Andreas M. Koupparis, Michalis Koutroumanidis, George K. Kostopoulos
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Nathaniel D. Sisterson, Vasileios Kokkinos, Alexandra Urban, Ningfei Li, R. Mark Richardson
Summary: This study reported outcomes of four patients with pharmacoresistant epilepsy undergoing thalamic-responsive neurostimulation treatment, showing a significant reduction in seizure frequency, duration and severity, as well as improvements in quality of life. The results remained durable through at least 2 years of therapy.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Chemistry, Multidisciplinary
Haiteng Jiang, Vasileios Kokkinos, Shuai Ye, Alexandra Urban, Anto Bagic, Mark Richardson, Bin He
Summary: This study developed a new method to localize the seizure onset zone (SOZ) and predict seizure outcome using short-time resting-state SEEG data. They found that greater differences in resting-state information flow between SOZ and non-SOZ regions are associated with favorable seizure outcome.
Article
Computer Science, Information Systems
Aikaterini Fragkou, Athanasios Kakarountas, Vasileios Kokkinos
Summary: The main goal of this study is to improve the battery lifespan of neurostimulation devices used for epilepsy treatment, and to achieve low power consumption rates and wireless data transmission.
Editorial Material
Clinical Neurology
Fabio A. Nascimento, Vasileios Kokkinos, Britt C. Emerton, Lauren B. Bolden, Athar N. Malik, Lidia M. V. R. Moura, R. Mark Richardson
EPILEPTIC DISORDERS
(2022)
Article
Clinical Neurology
Victoria Peterson, Vasileios Kokkinos, Enzo Ferrante, Ashley Walton, Timon Merk, Amir Hadanny, Varun Saravanan, Nathaniel Sisterson, Naoir Zaher, Alexandra Urban, R. Mark Richardson
Summary: This article introduces an intelligent system that can automatically detect the seizure patterns in patients with drug-resistant epilepsy and predict the onset time. The study shows that this system has high accuracy and reliability, which could save experts' evaluation time and has significant implications for therapeutic response assessment.
Article
Clinical Neurology
Vasileios Kokkinos
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Vasileios Kokkinos, Athanasios Chatzisotiriou, Ioannis Seimenis
Summary: This study aimed to evaluate the application of DTI-tractography and combined fMRI/DTI-tractography in resective brain surgery. The results showed that patients with DTI-tractography were more likely to experience improvement or preservation of preoperative neurological deficits (PNDs) at 1 month postoperatively, while patients with combined DTI-tractography/fMRI were more likely to have complete resolution of PNDs at 6 months. The use of combined DTI-tractography/fMRI also had a positive effect on the resolution of PNDs in patients with low-grade or high-grade lesions.
Article
Clinical Neurology
Vasileios Kokkinos, Ioannis Seimenis
Summary: This study investigates the differences between verbal memory fMRI and language fMRI in terms of lateralization and evaluates the effectiveness of word recognition during functional scans. The results show differences in signal spatial distribution and lateralization metrics between verbal memory and language fMRI tasks, and a correlation between word recognition and expressive and receptive language tasks.
JOURNAL OF NEUROIMAGING
(2023)
Article
Clinical Neurology
Panagiotis Kerezoudis, Vasileios Kokkinos
OPERATIVE NEUROSURGERY
(2022)
Article
Clinical Neurology
Elisaveta Sokolov, Nathaniel D. Sisterson, Helweh Hussein, Cheryl Plummer, Danielle Corson, Arun R. Antony, Joseph M. Mettenburg, Gena R. Ghearing, Jullie W. Pan, Alexandra Urban, Anto Bagic, R. Mark Richardson, Vasileios Kokkinos
Summary: The study highlights the value of intracranial monitoring in equalizing seizure outcomes in difficult-to-treat TLE patients undergoing ATL. Intracranial monitoring approaches showed similar outcomes in patients with TLE+ hypothesis, while sEEG performed well in patients with bilateral or poorly lateralized TLE. Importance of modifying primary hypothesis based on iEEG data was also emphasized.
Article
Clinical Neurology
Ankit N. Khambhati
Summary: RNS is a powerful tool for personalized treatment of drug-resistant, focal epilepsy, effectively reducing seizures. The stored chronic electrophysiology and therapy data in the RNS System can optimize device parameters. Emerging research can uncover complex relationships between stimulation, brain network physiology, and clinical outcomes, accelerating efficacy for a broader population with focal epilepsy.
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Article
Clinical Neurology
Angelique C. Paulk, Pariya Salami, Rina Zelmann, Sydney S. Cash
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Article
Clinical Neurology
Vasileios Kokkinos
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Editorial Material
Clinical Neurology
Vivek P. Buch, Josef Parvizi
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Article
Clinical Neurology
Rory J. Piper, George M. Ibrahim, Martin M. Tisdall
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Article
Clinical Neurology
Saadi Ghatan
Summary: Pediatric epilepsy surgery has gained recognition for its safety and effectiveness in treating epilepsy in children. Advances in diagnostic and treatment techniques, such as minimally invasive procedures and neuroimaging, have contributed to its rapid growth potential.
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Article
Clinical Neurology
Pranav Nanda, R. Mark Richardson
Summary: The MGH surgical epilepsy group's shift towards a seizure network paradigm has led to improvements in invasive monitoring methods, with more hypothesis-driven implantations, dominant use of sEEG depth electrodes, wider population coverage, and increased targeting of thalamic nuclei, optimizing the delineation of patients' seizure networks and critical treatment nodes.
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
