Article
Neurosciences
I Caprara, P. Janssen
Summary: Experimental evidence in macaque monkeys suggests that the frontal areas F5a and 45B play important roles in visually guided grasping, with the most significant impact observed in area F5p.
Article
Multidisciplinary Sciences
Clement M. Garin, Marie Garin, Leonardo Silenzi, Rye Jaffe, Christos Constantinidis
Summary: The size of the prefrontal cortex in humans is not disproportionately enlarged compared to other catarrhini species. However, humans have the most relatively enlarged frontal and parietal lobes in an infraorder exhibiting a disproportionate expansion of these areas.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Eric Mooshagian, Eric A. Yttri, Arthur D. Loewy, Lawrence H. Snyder
Summary: The canonical view of motor control states that distal muscles are primarily controlled by the contralateral cerebral hemisphere. However, recent studies have shown that the parietal reach region in the contralateral hemisphere plays a significant role in reach preparation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Roberto Caminiti, Gabriel Girard, Alexandra Battaglia-Mayer, Elena Borra, Andrea Schito, Giorgio M. Innocenti, Giuseppe Luppino
Summary: In macaque monkeys, the dorsal bank of the intraparietal sulcus (db-IPS) can be subdivided into a rostral intraparietal area PEip, projecting to the spinal cord, and a caudal medial intraparietal area MIP lacking such projections.
Article
Neurosciences
Jessica T. Jacobs, Rafael S. Maior, Hannah F. Waguespack, Carolina Campos-Rodriguez, Patrick A. Forcelli, Ludise Malkova
Summary: The bed nucleus of the stria terminalis (BNST) is involved in various social behaviors, including aggression, maternal care, mating behavior, and social interaction. Activation of the BNST has been shown to reduce social interaction between unfamiliar animals in rodent studies. However, the role of the BNST in social interaction in primates has not been investigated. By temporarily inactivating the BNST in male macaque monkeys, we found that BNST inactivation led to a significant increase in social interaction, accompanied by an increase in passive contact and a significant decrease in locomotion.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Rui Xu, Narcisse P. Bichot, Atsushi Takahashi, Robert Desimone
Summary: This study reveals the connectivity between the lateral prefrontal cortex (LPFC) and the rest of the cortex. The results show isomorphic mappings between LPFC and other major processing domains, suggesting LPFC's role in coordinating activity within and across these domains.
Article
Clinical Neurology
Hyun Chan Hwang, Sun Mi Kim, Doug Hyun Han
Summary: The study found that schizophrenic patients have lower emotional perception abilities compared to bipolar disorder patients, indicating disrupted emotional perception abilities are linked to altered brain functional connectivity. Schizophrenic patients show reduced usage of the frontal lobe, while bipolar patients compensate for facial emotion recognition using the parietal lobe.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Charalampos Papadimitriou, Charles D. Holmes, Lawrence H. Snyder
Summary: The study finds that the dynamics of memory cells during spatial memory periods are more complex than previously thought. They suggest that memory may be supported by multiple attractor networks working in parallel, with each network having its own characteristic mean turn-off time that gradually frees up mnemonic resources over time.
Article
Neurosciences
Adriana Boettcher, Saskia Wilken, Nico Adelhoefer, Markus Raab, Sven Hoffmann, Christian Beste
Summary: Sensorimotor integration is a crucial process in daily life, involving the integration of different sensory information. The role of theta- and beta-band activities in this process and the neuroanatomical structures involved were examined. The study found that beta-band activity in parietal cortices plays a role in the initial specification of indicator dynamics. When information about the goal was not accessible, higher theta-band activity in the superior frontal cortex was observed, indicating an increased need for control. Later, theta- and beta-band activities encoded different information within the ventral processing stream. Complex sensorimotor integration is achieved through a cascade of theta- and beta-band activities in a ventral-stream-parieto-frontal network.
Article
Biology
Alessandro Zanini, Audrey Dureux, Janahan Selvanayagam, Stefan Everling
Summary: The study found that the observation of others' actions activates a network of temporal, parietal and premotor/prefrontal areas in macaque monkeys and humans, which plays important roles in social action monitoring, learning by imitation, and social cognition. The researchers used ultra-high field fMRI at 9.4 T to observe common marmosets while they watched videos of goal-directed or non-goal-directed actions. The results showed that the observation of goal-directed actions activates a temporo-parieto-frontal network, which overlaps with the AON in humans and macaques, suggesting the existence of an evolutionarily conserved network that predates the separation of Old and New-World primates.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Camille Giacometti, Audrey Dureux, Delphine Autran-Clavagnier, Charles R. E. Wilson, Jerome Sallet, Manon Dirheimer, Emmanuel Procyk, Fadila Hadj-Bouziane, Celine Amiez
Summary: This study investigates the impact of anesthesia on the functional connectivity organization of a cingulo-frontal cortical network in macaque monkeys. It reveals a similar organization to that found in the human brain, but this organization can only be observed in the awake state, suggesting anesthesia sensitivity and caution needed when comparing species under different states.
Article
Neurosciences
Bo Zhang, Fan Wang, Qi Zhang, Yuji Naya
Summary: Our mental representation of egocentric space is influenced by the disproportionate sensory perception of the body. Previous studies have focused on the neural architecture for egocentric representations within the visual field. However, the space representation underlying the body is still unclear. This study used fMRI and MEG to investigate the spatial representation of targets relative to the body and found that the frontoparietal network is more involved in representing left/right targets, while the MTL-parietal network is more involved in retrieving targets behind the participant. MEG data also showed an earlier activation of the MTL-parietal network during target retrieval.
Article
Geriatrics & Gerontology
Steven Dash, Byung Park, Christopher D. Kroenke, William D. Rooney, Henryk F. Urbanski, Steven G. Kohama
Summary: This study found that the rhesus macaque, a long-lived nonhuman primate with a brain structure similar to humans, can serve as a valuable animal model for studying human brain aging. By conducting magnetic resonance imaging scans on 66 macaques, the researchers observed changes in brain structures in older animals, such as enlargement of the lateral ventricles and volume reductions in the frontal cortex, caudate, putamen, hypothalamus, and thalamus. Additionally, there were differences between males and females in both white and gray matter regions. The rhesus macaque presents an ideal model for studying the onset and mitigation of neurodegenerative diseases.
NEUROBIOLOGY OF AGING
(2023)
Review
Anatomy & Morphology
Joanita F. D'Souza, Nicholas S. C. Price, Maureen A. Hagan
Summary: Visual neuroscientists have utilized technology, methodology, and models to gain insights into the structure and function of individual brain areas, but complex cognitive functions in the brain arise from networks of multiple interacting cortical areas. Key regions in the frontal-parietal network, such as the frontal eye fields and lateral intraparietal area, have been associated with functions like oculomotor control and decision-making, with strong anatomical connections between them. The common marmoset is proposed as an ideal model for studying how anatomical connections contribute to complex cognitive visual behaviors, due to its cortical network homology with humans and macaques, transgenic technology compatibility, and lissencephalic brain structure allowing for advanced techniques like electrophysiology and optogenetics.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Biology
Kiri Kuroda, Yukiko Ogura, Akitoshi Ogawa, Tomoya Tamei, Kazushi Ikeda, Tatsuya Kameda
Summary: In the digital era, new socially shared realities and norms emerge rapidly through social interactions. These interactions promote convergence of perceptual responses among people, resulting in shared generative models and agreement on new targets.
COMMUNICATIONS BIOLOGY
(2022)
Article
Clinical Neurology
Nandor Ludvig, Shirn L. Baptiste, Hai M. Tang, Geza Medveczky, Hans von Gizycki, Jean Charchaflieh, Orrin Devinsky, Ruben I. Kuzniecky
Article
Clinical Neurology
Deepak Madhavan, Piotr Mirowski, Nandor Ludvig, Chad Carlson, Werner Doyle, Orrin Devinsky, Ruben Kuzniecky
Article
Neurosciences
Andre A. Fenton, Hsin-Yi Kao, Samuel A. Neymotin, Andrey Olypher, Yevgeniy Vayntrub, William W. Lytton, Nandor Ludvig
JOURNAL OF NEUROSCIENCE
(2008)
Article
Biochemical Research Methods
Nandor Ludvig, Geza Medveczky, Richard Rizzolo, Hai M. Tang, Shirn L. Baptiste, Werner K. Doyle, Orrin Devinsky, Chad Carlson, Jacqueline A. French, John G. Kral, Jean Charchaflieh, Ruben I. Kuzniecky
JOURNAL OF NEUROSCIENCE METHODS
(2012)
Article
Clinical Neurology
Nandor Ludvig, Hai M. Tang, Shirn L. Baptiste, Geza Medveczky, Jonathan K. Vaynberg, Jacqueline Vazquez-DeRose, Dimitre G. Stefanov, Orrin Devinsky, Jacqueline A. French, Chad Carlson, Ruben I. Kuzniecky
JOURNAL OF NEUROSURGERY
(2012)
Article
Medicine, Research & Experimental
John G. Kral, Nandor Ludvig
MEDICAL HYPOTHESES
(2013)
Article
Neurosciences
N Ludvig, HM Tang, BC Gohil, JM Botero
Article
Behavioral Sciences
N Ludvig, HM Tang, H Eichenbaum, BC Gohil
BEHAVIOURAL BRAIN RESEARCH
(2003)
Article
Biochemical Research Methods
N Ludvig, L Kovacs, L Kando, G Medveczky, HM Tang, LP Eberle, CR Lemon
BRAIN RESEARCH PROTOCOLS
(2002)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)