Article
Chemistry, Applied
Da Huang, Kristoffer Valerie, Hu Yang
Summary: Clickable polymers, especially brush polymers formed by the conjugation of polyethylene glycol (PEG) to clickable polymers, have gained attention in the biomedical field for their ability to carry various functional moieties and enhance drug delivery systems. Recently, a clickable brush polymer PEAMO-g-PEG was developed, which exhibited excellent water solubility, biocompatibility, and flexibility for coupling therapeutic drugs. A novel polymeric drug delivery platform was developed using this technology, resulting in improved survival in brain cancer therapy.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Review
Oncology
Randy S. D'Amico, Manish K. Aghi, Michael A. Vogelbaum, Jeffrey N. Bruce
Summary: Convection-enhanced delivery (CED) is a method of targeted, local drug delivery to the central nervous system that shows promise for treating glioblastoma (GBM), although the long-term efficacy of the agents studied remains difficult to assess at present.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Pavan S. Upadhyayula, Eleonora F. Spinazzi, Michael G. Argenziano, Peter Canoll, Jeffrey N. Bruce
Summary: Convection enhanced delivery (CED) is a technique used for treating glioma by infusing treatments directly into the brain parenchyma. The manuscript describes the physical principles behind CED, common pitfalls, and optimization methods. The institutional experience using topotecan CED for malignant glioma treatment is highlighted.
Article
Pharmacology & Pharmacy
Yan-Xi Zhou, Xiao-Yu Cao, Cheng Peng
Summary: This study analyzed the 100 most-cited articles on curcumin, providing insights into the characteristics and research hotspots of these articles, including the countries, institutions, authors, journals, and research directions involved in the study.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Xinxing Fei, Qiu Zeng, Jianxiong Wang, Yaqian Gao, Fangyuan Xu
Summary: This study conducted a bibliometric analysis of the 100 most-cited articles in the field of delirium, aiming to identify the current status and global trends. The findings suggest that risk factors for delirium, psychometric evaluation, hospital care, and various clinical study designs remain the focus of research in this field.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Lv Xie, Bingwei Lu, Yezhi Ma, Jiemin Yin, Xiaozhu Zhai, Chen Chen, Wanqing Xie, Yueman Zhang, Li Zheng, Peiying Li
Summary: This study conducted a bibliometric analysis on the role of the neurovascular unit (NVU) in stroke, revealing that most authors are from the United States and Japan, with emerging countries like Romania, Hungary, and Poland. The majority of highly-cited articles were published between 2011-2015.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Xue Du, Chunbao Chen, Lu Yang, Yu Cui, Bangxian Tan
Summary: This study visualized the scientific achievements and research trends of applying nanotechnology in glioma treatment. China had the highest number of publications in this field, and strong collaboration among research institutions was observed. Drug delivery was identified as a hot topic based on keyword frequency.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Surgery
Ruizhi He, Taoyuan Yin, Shutao Pan, Min Wang, Hang Zhang, Renyi Qin
Summary: This bibliometric analysis study provides a comprehensive understanding of research on pancreaticoduodenectomy (PD) surgery by analyzing the top 100 most-cited articles related to this procedure. The study found that the USA dominates in terms of articles, researchers, and institutions in PD surgery research.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Review
Psychiatry
Qingyun Wan, Kai Liu, Xiaoqiu Wang, Shuting Luo, Xiya Yuan, Chi Wang, Jing Jiang, Wenzhong Wu
Summary: This study identified and analyzed the 100 most cited papers in insomnia research, providing researchers and clinicians with a detailed overview of the influential articles in the field. The results highlighted the focus on sleep measurement and treatment methods, as well as the potential areas of future research such as psychiatric disorders and cognitive behavioral therapy. This analysis is valuable for guiding further studies and clinical practice.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Oncology
Peichen Xiao, Chenchen Yao, Guangxin Wang
Summary: This study analyzed the top 100 most cited papers and research trends on endometrial carcinoma using bibliometric methods. The results showed that the United States is a leader in this field, with increasing attention on the clinical treatment of endometrial carcinoma. Potential research hotspots, such as external-beam radiotherapy, uterine serous carcinoma, and intermediate-risk, were recommended for further study.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiyeon Ha, Dae Young Yoon, Sora Baek, Chae Woon Lee, Kyoung Ja Lim, Young Lan Seo, Eun Joo Yun
Summary: This study aimed to identify the 100 most-cited and 100 most-mentioned COVID-19-related radiological articles and compare their characteristics. The most frequently cited articles were published before November 2020, originated from China, covered the topic of COVID-19 diagnosis, and were related to pulmonary imaging. On the other hand, the most frequently mentioned articles were published after December 2020, originated from the USA, covered the topic of COVID-19 sequelae diagnosis and post-vaccination complications, and were related to cardiac imaging and neuroradiology.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, Research & Experimental
Yu Song, Lishan Zhang, Yongshi Yang, Jinlyu Sun
Summary: Bibliometric analysis was conducted to identify and analyze the top 100 most cited articles in the field of anaphylaxis. The analysis revealed the publication trends, author affiliations, and research focuses in anaphylaxis. The results provide insights into the progress and hotspots of research in this field.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Susan Fox, Julie Lynch, Paul D'Alton, Alan Carr
Summary: This study provides a comprehensive overview of the top 100 most-cited journal articles in psycho-oncology research, highlighting a significant correlation between years since publication and citation count. The majority of research originated from the United States, with observational research study designs and original articles representing a large proportion of publications.
Article
Medicine, General & Internal
Yan Teng, Sujing Li, Yibin Fan, Xiaohua Tao, Youming Huang
Summary: This study used bibliometric analysis to identify and analyze the top 100 most-cited publications related to hidradenitis suppurativa (HS). The findings indicate significant progress in the understanding and treatment of HS, with a range of critical publications offering important reviews, guidelines, and original research articles.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Kaili Yang, Liyan Xu, Shaopei Wang, Meng Zhu, Qi Fan, Yuwei Gu, Yawen Wang, Qing Wang, Dongqing Zhao, Chenjiu Pang, Shengwei Ren
Summary: This study conducted a comprehensive analysis of the top 100-cited articles on corneal cross-linking (CXL) research, providing insights into research developments over the past decades.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Erica A Power, Julian S. Rechberger, Victor M. Lu, David J. Daniels
Article
Anatomy & Morphology
Santino Ottavio Tomasi, Giuseppe Emmanuele Umana, Gianluca Scalia, Roberto Luis Rubio-Rodriguez, Giuseppe Raudino, Julian Rechberger, Philipp Geiger, Bipin Chaurasia, Kaan Yagmurlu, Michael T. Lawton, Peter A. Winkler
Summary: This study provides a detailed analysis of the perforating arteries in the lemniscal trigone of the midbrain, revealing origins not only from the superior cerebellar artery but also from the posterior cerebral artery. It emphasizes the importance of preserving these vessels and associated perforators during surgery to prevent brainstem infarction.
FRONTIERS IN NEUROANATOMY
(2021)
Editorial Material
Pharmacology & Pharmacy
Julian S. Rechberger, Cody L. Nesvick, David J. Daniels
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Editorial Material
Pharmacology & Pharmacy
Julian S. Rechberger, Charlotte A. Brown, Frederic Thiele, Erica A. Power, David J. Daniels
THERAPEUTIC DELIVERY
(2021)
Review
Pharmacology & Pharmacy
Erica A. Power, Julian S. Rechberger, Sumit Gupta, Jonathan D. Schwartz, David J. Daniels, Soumen Khatua
Summary: Although there has been a surge in the identification of molecular targets and targeted therapies in pediatric brain tumors in the last decade, the blood brain barrier (BBB) remains a significant challenge for systemic drug delivery. Recent efforts have identified strategies to enhance drug delivery into pediatric brain tumors, including invasive and non-invasive technologies.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Julian S. Rechberger, Kendra A. Porath, Liang Zhang, Cody L. Nesvick, Randy S. Schrecengost, Jann N. Sarkaria, David J. Daniels
Summary: GB-13, a novel peptide-toxin conjugate, demonstrates promising pharmacological effects by targeting IL-13R alpha 2 upregulated HGG cells, inducing apoptosis and inhibiting cell proliferation. Direct intratumoral administration of GB-13 reduces tumor burden and prolongs survival.
Editorial Material
Pharmacology & Pharmacy
Julian S. Rechberger, David J. Daniels
THERAPEUTIC DELIVERY
(2022)
Review
Medicine, General & Internal
Gabriel Illmeier, Julian S. Rechberger
Summary: Based on previous research, the belief that the knees should only move forward until they align with the feet during the barbell squat is still prevalent. However, recent studies have shown conflicting results regarding anterior knee displacement. For most athletes, allowing some degree of anterior knee displacement may be beneficial to avoid excessive stress on the lumbar spine and hip. Overall, restricting this natural movement is not effective for healthy trained individuals, except for knee rehabilitation patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Jawad Fares, Zachary B. Davis, Julian S. Rechberger, Stephanie A. Toll, Jonathan D. Schwartz, David J. Daniels, Jeffrey S. Miller, Soumen Khatua
Summary: Despite current treatment advancements for brain tumors, including surgery, chemotherapy, and radiation, the prognosis remains poor, especially for recurrent cases. The close proximity to delicate neural structures often prevents complete surgical removal, and the toxicities of systemic therapy are a concern. However, the field of NK cell-based cancer therapy shows promise as a new avenue for treating brain tumors.
NPJ PRECISION ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Wouter J. F. Vanbilloen, Julian S. Rechberger, Jacob B. Anderson, Leo F. Nonnenbroich, Liang Zhang, David J. Daniels
Summary: Primary brain and central nervous system (CNS) tumors are a diverse group of neoplasms that occur within the brain and spinal cord. The unique challenges presented by the brain-CSF barrier and blood-brain barrier have hindered the translation of advances in understanding CNS tumor progression into effective therapies. Nanoparticles offer a potential solution for targeted CNS tumor therapeutics delivery by bypassing these barriers.
Review
Medicine, General & Internal
Julian S. Rechberger, Stephanie A. Toll, Wouter J. F. Vanbilloen, David J. Daniels, Soumen Khatua
Summary: This review provides an update on the molecular landscape of medulloblastoma and treatment strategies. It discusses the four main molecular subgroups (WNT-activated, SHH-activated, and non-WNT/non-SHH groups 3 and 4), highlighting the key genetic alterations and signaling pathways associated with each entity. It also explores the emerging role of epigenetic regulation in medulloblastoma and the mechanism of resistance to therapy, as well as the latest developments in targeted therapies and immunotherapies.
Review
Biochemistry & Molecular Biology
Karolina Pellot I. Ortiz, Julian S. Rechberger, Leo F. Nonnenbroich, David J. Daniels, Jann N. Sarkaria
Summary: Inhibition of MDM2 and p53 interaction is a promising strategy for treating cancer, particularly glioblastoma. Multiple MDM2 inhibitors are being tested for their potential in glioblastoma therapy, with encouraging results seen in cell culture and animal models. Combination therapy with established treatments like radiation and chemotherapy, as well as other molecularly targeted therapies, could enhance therapeutic response. However, the efficacy of MDM2 inhibitors, both alone and in combination, is still being evaluated in ongoing clinical trials for glioblastoma patients.
Editorial Material
Pharmacology & Pharmacy
Elena Millesi, Julian S. Rechberger, Huan Wang, Samir Mardini, Robert J. Spinner, David J. Daniels
Summary: Emerging targeted therapies provide hope for the treatment of malignant peripheral nerve sheath tumors. Innovative drug delivery methods enhance the effectiveness of potential treatments.
THERAPEUTIC DELIVERY
(2023)
Article
Oncology
Erica A. Power, Julian S. Rechberger, Liang Zhang, Ju-Hee Oh, Jacob B. Anderson, Cody L. Nesvick, Jizhi Ge, Edward H. Hinchcliffe, William F. Elmquist, David J. Daniels
Summary: This study identifies a novel targeted therapy for H3K27-altered DMG by using drug screening and models. By extending the drug residence time in the tumor through continuous infusion, the treatment strategy significantly improves survival in patients.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Pharmacology & Pharmacy
Julian S. S. Rechberger, Blake T. T. Power, Erica A. A. Power, Cody L. L. Nesvick, David J. J. Daniels
Summary: Despite progress in understanding the molecular basis of H3K27-altered diffuse midline glioma (DMG), challenges remain in delivering drugs across the blood-brain barrier (BBB) to the tumor site. This review discusses the potential of convection-enhanced delivery (CED) as a promising treatment modality for DMG, and outlines a comprehensive approach that could improve successful clinical implementation of therapeutic agents.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)