Article
Clinical Neurology
Willemiek J. E. M. Zweiphenning, Nicolas von Ellenrieder, Francois Dubeau, Laurence Martineau, Lorella Minotti, Jeffery A. Hall, Stephan Chabardes, Roy Dudley, Philippe Kahane, Jean Gotman, Birgit Frauscher
Summary: Comparing abnormal high-frequency oscillation rates to rates in healthy tissue improves focus identification and outcome prediction in epileptic patients undergoing surgery.
Article
Materials Science, Multidisciplinary
Qi Zhang, Yang Zhao, Lin Wang, Mingyi Wei, Mei Yu, Jianping Huang, Guanglin Li, Renheng Wang, Shiwei Du, Zhiyuan Liu
Summary: In this study, stretchable micro electrocorticogram (mECoG) electrodes were developed and used to monitor and study the epileptic activities during seizures. The researchers found that the characteristic epileptic spike waves occur first in the visual cortex, and 15 minutes of electrical stimulus has the best restraining effect on epileptic seizures.
SCIENCE CHINA-MATERIALS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fang Liu, Weiwei Ruan, Xuejun Deng, Yangmeihui Song, Wenyu Song, Fan Hu, Jinxia Guo, Xiaoli Lan
Summary: The study demonstrates that delayed (18)F-FDG PET imaging can effectively assist in identifying epileptogenic zones (EZs) with significant metabolic asymmetry in patients with epilepsy, especially in those with positive MRI results, extratemporal lobe epilepsy (extra-TLE), and shorter delay time points.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Behavioral Sciences
Ayse Kacar Bayram, Qi Yan, Cigdem Isitan, Shilpa Rao, Dennis D. Spencer, Rafeed Alkawadri
Summary: This systematic literature review investigates the effect of anesthetic agents on intraoperative electrocorticography (ECoG) quality and reliability for localizing the epileptic focus. The review found favorable reports for dexmedetomidine and remifentanil during ECoG recording, but insufficient or conflicting evidence for other anesthetic agents. The study emphasizes the importance of optimizing ECoG recordings through proper use of anesthetic agents, careful dose titration, and effective communication between neurophysiologists and anesthesiologists.
EPILEPSY & BEHAVIOR
(2021)
Review
Clinical Neurology
Giulia Spoto, Giulia Valentini, Maria Concetta Saia, Ambra Butera, Greta Amore, Vincenzo Salpietro, Antonio Gennaro Nicotera, Gabriella Di Rosa
Summary: The proper connection between pre- and post-synaptic nervous cells relies on various components including membranes, the synaptic cleft, glial cells, and extracellular matrix. Synaptopathy refers to the alteration of mechanisms regulating these synaptic components and is associated with neuropsychiatric disorders. Developmental and Epileptic Encephalopathies (DEEs) are a group of epilepsy syndromes associated with cognitive disturbances, intellectual disability, autistic features, and movement disorders. This review focuses on the pathogenesis of DEEs, particularly on the role of pre-synaptic terminals and potential therapeutic approaches.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Md. Rabiul Islam, Xuyang Zhao, Yao Miao, Hidenori Sugano, Toshihisa Tanaka
Summary: This article reviews AI solutions for epilepsy focus detection based on EEG signals, categorizing them into biomarkers, feature extraction, and neural networks. It also highlights research challenges and provides guidelines for using these systems.
COGNITIVE NEURODYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Tatiana Sokolova, Yulia M. Zabrodskaya, Anastasia Litovchenko, Natalia M. Paramonova, Vugar R. Kasumov, Svetlana Kravtsova, Ekaterina N. Skiteva, Daria A. Sitovskaya, Elena D. Bazhanova
Summary: This study evaluated neuronal and glial apoptosis in the brain epileptic focus and inflammatory changes in the blood in patients with focal drug-resistant epilepsy. The results showed signs of apoptosis in neurons and oligodendrocytes in the temporal lobe of DRE patients. Increased levels of proinflammatory cytokines and decreased levels of anti-inflammatory cytokines were observed. Oligodendroglial apoptosis was found to play an important role in DRE pathogenesis and explain demyelination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Regina Trollmann
Summary: Neuromonitoring of at-risk neonates is crucial due to the wide spectrum of etiologies of neonatal-onset epileptic encephalopathies. EEG and amplitude-integrated EEG are sensitive tools for early detection of abnormal brain activity. They are particularly important for monitoring neonates with acute symptomatic, structural, metabolic, or genetic neonatal-onset EE.
FRONTIERS IN NEUROLOGY
(2021)
Article
Engineering, Biomedical
Cansel Ficici, Ziya Telatar, Osman Erogul
Summary: A method analyzing gray matter reduction in brain magnetic resonance images was proposed to identify epileptogenic focus of temporal lobe epilepsy (TLE) patients. Experimental results showed that the proposed algorithm can reveal subtle Gray matter reduction in the temporal lobe and limbic lobe areas, thus providing an automated medical support system for the expert in identifying the epileptic focus of TLE patients.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Biochemistry & Molecular Biology
Aikaterini Vezyroglou, Peter Hebden, Isabel De Roever, Rachel Thornton, Subhabrata Mitra, Alan Worley, Mariana Alves, Emma Dean, Judith Helen Cross, Ilias Tachtsidis
Summary: This study used bNIRS technology to measure metabolic activity and brain tissue hemodynamics/oxygenation during epileptic seizures in a 3-year-old girl with extensive malformation of cortical development. The results showed an increase in brain tissue oxygenation during seizures, but little change in the area with developmental abnormalities. Additionally, in the epileptic focus area, cellular oxygen metabolism significantly decreased during seizure generalization, suggesting an inability to sustain and increase brain tissue metabolism during seizures.
Article
Pharmacology & Pharmacy
Yang Hu, Yuanyuan Yao, Honggang Qi, Jiurong Yang, Canyu Zhang, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan, Xinjian Zhu
Summary: This study reveals the mechanism by which microglia regulate epileptic neuronal hyperexcitability through CD39-dependentsignaling, highlighting the importance of the interaction between microglia and neurons in epilepsy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Vijendra Sharma, Rapita Sood, Danning Lou, Tzu-Yu Hung, Maxime Levesque, Yelin Han, Jeremy Y. Levett, Peng Wang, Shravan Murthy, Shannon Tansley, Siyan Wang, Nadeem Siddiqui, Soroush Tahmasebi, Kobi Rosenblum, Massimo Avoli, Jean-Claude Lacaille, Nahum Sonenberg, Arkady Khoutorsky
Summary: mTORC1-dependent translation plays a crucial role in epilepsy pathophysiology, with 4E-BP2 expression in inhibitory neurons increasing susceptibility to seizure induction. This highlights the central role of elevated mTORC1 activity in inhibitory neurons in the pathophysiology of epilepsy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Veterinary Sciences
C. Akos Szabo, Felipe S. Salinas
Summary: Characterization of the baboon model of genetic generalized epilepsy (GGE) is achieved through electroclinical analysis and the use of neuroimaging techniques, such as MRI and PET. The baboon's phylogenetic proximity and similar brain structure to humans make it an excellent translational model for studying GGE. Its large brain size, gyrencephalic structure, and availability of a large pedigreed colony allow for exploration of neuroimaging markers of the disease. The use of functional and structural imaging has provided insights into the baboon model of GGE.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Clinical Neurology
Le Zhang, Ettore Beghi, Torbjorn Tomson, Massimiliano Beghi, Giuseppe Erba, Zheng Chang
Summary: The study compared mortality, comorbidities, and causes of death in individuals with PNES, epilepsy, and the general population. Results showed that PNES patients had a significantly higher all-cause mortality rate compared to controls, with higher risks of both natural and non-natural causes of death, particularly suicide. This association varied with age and time since diagnosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Eva Martinez-Lizana, Armin Brandt, Niels A. Foit, Horst Urbach, Andreas Schulze-Bonhage
Summary: This study provides an in-depth analysis of ictal semiology in insulo-opercular epilepsy (IOE) compared to mesial temporal lobe epilepsy (MTE), identifying distinguishing features that can aid in syndrome classification and guide appropriate diagnostic and local therapeutic procedures. The research found that certain ictal features, such as somatosensory sensations and automatisms, were more frequent in IOE than in MTE, allowing for correct identification of each epilepsy type in a significant percentage of cases.
JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Ashish H. Shah, Vaidya Govindarajan, Tara T. Doucet-O'Hare, Sarah Rivas, Leo Ampie, Catherine DeMarino, Yeshavanth Kumar Banasavadi-Siddegowda, Yong Zhang, Kory R. Johnson, Fahad Almsned, Mark R. Gilbert, John D. Heiss, Avindra Nath
Summary: Human Endogenous RetroViruses (HERVs) play a potential oncogenic role in cancer cells and their expression in gliomas is correlated with locus-specific epigenetic modifications. HML-6, a retroviral transcript, is found to be overexpressed in glioblastoma and its gene product, ERVK3-1, is associated with poor prognosis in GBM patients regardless of IDH-mutational status. These findings may impact our understanding of tumor biology in GBM and suggest ERVK3-1 as a potential therapeutic target.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Francia Y. Fang, Jared S. Rosenblum, Winson S. Ho, John D. Heiss
Summary: This article provides a comprehensive overview of medulloblastoma, the most common pediatric brain tumor, and its four molecular subtypes. It highlights the advancements in understanding the disease and the potential for improved treatment strategies in pediatric patients. The article also discusses the importance of further research and development in this field.
Review
Oncology
Mynor J. Mendez Valdez, Victor M. Lu, Enoch Kim, Sarah R. Rivas, Vaidya Govindarajan, Michael Ivan, Ricardo Komotar, Avindra Nath, John D. Heiss, Ashish H. Shah
Summary: The incidence of GBM in PLWH is not well-documented and further research is needed for improved treatment strategies. The median overall survival from GBM diagnosis in PLWH is 8 months, with 1-year and 2-year survival rates of 28% and 5% respectively. There are currently no significant predictors of OS in this setting.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Matthew T. Rocco, Asad S. Akhter, Debra J. Ehrlich, Gretchen C. Scott, Codrin Lungu, Vikas Munjal, Anthony Aquino, Russell R. Lonser, Massimo S. Fiandaca, Mark Hallett, John D. Heiss, Krystof S. Bankiewicz
Summary: This study investigated the direct infusion of adeno-associated virus vector (AAV2) containing the GDNF transgene into the putamen of patients with advanced Parkinson's disease. Real-time intraoperative magnetic resonance imaging (iMRI) using a surrogate imaging tracer was used to track the distribution of the infused substance. The results confirmed the safety and efficacy of this delivery method, with no evidence of cerebral toxicity observed in the long-term follow-up. The use of real-time imaging during the procedure allows for precise placement of the infusion cannula and adjustment of infusion rate, improving the safety and effectiveness of the treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mihika Gangolli, Wen-Tung Wang, Neville D. Gai, Dzung L. Pham, John A. Butman
Summary: This study aimed to determine whether a diffusion gradient table can acquire data to estimate both dynamic and diffusion tensor imaging (DTI) metrics simultaneously. The results showed that using a nested cubes diffusion gradient table in a single acquisition can produce tensor-based and dynamic diffusion measurements.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
John D. Heiss
NEUROSURGERY CLINICS OF NORTH AMERICA
(2023)
Editorial Material
Clinical Neurology
Xueting Jin, Zied Abdullaev, John A. Butman, Sara K. Inati, Shareena A. Rahman, Kareem A. Zaghloul, Antonios Papanicolau-Sengos, Drew W. Pratt, Kenneth D. Aldape, Martha M. Quezado
Article
Engineering, Biomedical
Andrew K. Knutsen, Suhas Vidhate, Grace McIlvain, Josh Luster, Eric J. Galindo, Curtis L. Johnson, Dzung L. Pham, John A. Butman, Ricardo Mejia-Alvarez, Michaelann Tartis, Adam M. Willis
Summary: Traumatic brain injury (TBI) is a significant health concern with a gap in understanding the relationship between impulsive loadings and injury patterns. This study introduces the ANGUS phantom, a synthetic model that mimics the human brain, and compares its response to data from human subjects. The results suggest that the ANGUS phantom is suitable for reproducing the brain's response to linear impulses but requires improvement for rotational impacts.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Medicine, General & Internal
Hannah P. Famili, Christopher K. Zalewski, Alaaddin Ibrahimy, Jessica Mack, Fredric Cantor, John D. Heiss, Carmen C. Brewer
Summary: This study aimed to describe the audiovestibular phenotype in patients with CM1 and dizziness symptoms. Vestibular abnormalities, especially functional balance impairment, were common in these patients. Neck pain was negatively associated with somatosensory analysis score. Although isolated peripheral vestibulopathy was rare, vestibular/balance assessment is important for identifying patients who may benefit from specialized medical care.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Dardo Tomasi, Peter Manza, Jean Logan, Ehsan Shokri-Kojori, Michele-Vera Yonga, Danielle Kroll, Dana Feldman, Katherine McPherson, Catherine Biesecker, Evan Dennis, Allison Johnson, Kai Yuan, Wen-Tung Wang, John A. Butman, Gene-Jack Wang, Nora D. Volkow
Summary: Combined PET imaging and mathematical simulations show that the rate of dopamine increase in the striatum is the basis for self-reports of drug high in response to oral and intravenous methylphenidate challenges. This study reveals that the speed of dopamine increases, in addition to its amplitude, plays a role in drug reward. The findings suggest that intravenous methylphenidate induces faster dopamine increases compared to oral methylphenidate, and the time-to-peak is associated with the intensity of the self-report of high.
COMMUNICATIONS BIOLOGY
(2023)
Article
Clinical Neurology
Alaaddin Ibrahimy, Tianxia Wu, Jessica Mack, Gretchen C. Scott, Michaela X. Cortes, Fredric K. Cantor, Francis Loth, John D. Heiss
Summary: This study showed that patients with Chiari I malformation experienced enlargement of CSF areas and improvement in quality of life after craniocervical decompression surgery, with most changes occurring within the first year post-operation. Overall, a 1-year follow-up period seemed sufficient for evaluating surgical efficacy and postoperative imaging changes.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Genetics & Heredity
Isabelle Roux, Cristina Fenollar-Ferrer, Hyun Jae Lee, Parna Chattaraj, Ivan A. Lopez, Kyungreem Han, Keiji Honda, Carmen C. Brewer, John A. Butman, Robert J. Morell, Donna M. Martin, Andrew J. Griffith
Summary: Enlargement of the endolymphatic sac, duct, and vestibular aqueduct (EVA) is a common inner ear malformation in patients with hearing loss, and is associated with pathogenic variants in SLC26A4. However, in European-Caucasian populations, around 50% of EVA patients have no pathogenic alleles of SLC26A4. This study found that CHD7 variants can cause EVA and nonsyndromic hearing loss, and suggest that CHD7 should be included in DNA sequence analyses for EVA patients.
Article
Medicine, General & Internal
Eric A. Kohut, Shantelle A. Graff, Samuel H. Wakelin, Martin Arhin, Govind Nair, John D. Heiss
Summary: Neurosurgeons use MRI scans to evaluate the reduction in syrinx size after surgical treatment. Manual measurement of syrinx volume is time-consuming and prone to errors. Developing convenient semiautomated methods for volumetric analysis can improve the monitoring of syringomyelia. This study compared two semiautomated methods (SCAT and 3DQI) with a manual method (CAV) and found that all methods detected a decrease in syrinx volume after surgery. The semiautomated methods showed efficient and accurate results for clinical decision-making and research studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Rebecca A. Drummond, Jigar V. Desai, Amy P. Hsu, Vasileios Oikonomou, Donald C. Vinh, Joshua A. Acklin, Michael S. Abers, Magdalena A. Walkiewicz, Sarah L. Anzick, Muthulekha Swamydas, Simon Vautier, Mukil Natarajan, Andrew J. Oler, Daisuke Yamanaka, Katrin D. Mayer-Barber, Yoichiro Iwakura, David Bianchi, Brian Driscoll, Ken Hauck, Ahnika Kline, Nicholas S. P. Viall, Christa S. Zerbe, Elise M. N. Ferre, Monica M. Schmitt, Tom DiMaggio, Stefania Pittaluga, John A. Butman, Adrian M. Zelazny, Yvonne R. Shea, Cesar A. Arias, Cameron Ashbaugh, Maryam Mahmood, Zelalem Temesgen, Alexander G. Theofiles, Masayuki Nigo, Varsha Moudgal, Karen C. Bloch, Sean G. Kelly, M. Suzanne Whitworth, Ganesh Rao, Cindy J. Whitener, Neema Mafi, Juan Gea-Banacloche, Lawrence C. Kenyon, William R. Miller, Katia Boggian, Andrea Gilbert, Matthew Sincock, Alexandra F. Freeman, John E. Bennett, Rodrigo Hasbun, Constantinos M. Mikelis, Kyung J. Kwon-Chung, Yasmine Belkaid, Gordon D. Brown, Jean K. Lim, Douglas B. Kuhns, Steven M. Holland, Michail S. Lionakis
Summary: The study explores the immune protection mechanisms against subcutaneous phaeohyphomycosis caused by viral particles. The researchers found that CLEC7A gene mutations are associated with susceptibility to the disease. Animal experiments further confirmed the importance of this gene in immune defense against phaeohyphomycosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Oncology
Ashish Shah, Vaidya Govindarajan, Tara Doucet-O'Hare, Sarah Rivas, Leo Ampie, Catherine DeMarino, Yeshavanath Banasavadi-Siddegowda, Yong Zhang, Kory Johnson, Fahad Almsned, Mark Gilbert, John Heiss, Avindra Nath