Article
Neurosciences
Hua Zhang, Caitlynn Knight, S. R. Wayne Chen, Ilya Bezprozvanny
Summary: It has been found that RyanR is overactive in Alzheimer's disease (AD) and inhibiting RyanR may be beneficial for AD treatment. This study investigated the potential connection between basal RyanR activity and autophagy in neurons. The results showed that the basal RyanR2 activity inhibited autophagy through the calcineurin-AMPK-ULK1 pathway, and increased basal RyanR2 activity in AD may lead to the inhibition of neuronal autophagy and accumulation of β-amyloid. The findings suggest that reducing RyanR2 activity may be a potential target for therapeutic intervention in AD.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Stefania Merighi, Alessia Travagli, Manuela Nigro, Silvia Pasquini, Martina Cappello, Chiara Contri, Katia Varani, Fabrizio Vincenzi, Pier Andrea Borea, Stefania Gessi
Summary: Alzheimer's disease (AD) is the most common form of dementia, with an estimated 135 million cases worldwide by 2050. Current medications for AD only alleviate symptoms and do not modify the disease progression. Clinical studies suggest that caffeine, through its antagonistic action on A(2A) receptors, may have neuroprotective effects against neurodegenerative conditions like AD. This review highlights the critical role of A(2A) receptors in memory loss and cognitive decline, and the potential benefits of caffeine's antagonistic action on these receptors in neurodegeneration.
Article
Physiology
Carme Nolla-Colomer, Sergi Casabella-Ramon, Veronica Jimenez-Sabado, Alexander Vallmitjana, Carmen Tarifa, Adela Herraiz-Martinez, Anna Llach, Manel Tauron, Jose Montiel, Juan Cinca, S. R. Wayne Chen, Raul Benitez, Leif Hove-Madsen
Summary: The study revealed that most sparks are caused by activation of a single RyR2 cluster at baseline, while beta-adrenergic stimulation doubles the mass and the number of clusters per spark. The spark mass was also higher in patients with atrial fibrillation compared to those without.
Article
Cardiac & Cardiovascular Systems
Rui Song, Xiang-Qun Hu, Monica Romero, Mark A. Holguin, Whitney Kagabo, Daliao Xiao, Sean M. Wilson, Lubo Zhang
Summary: Pregnancy increases the association of BKCa channel subunits and alters the localization of RyR subtypes in uterine arteries. Knockdown of RyR1 or RyR2 decreases Ca2+ sparks and STOCs frequency, increases myogenic tone, while RyR3 knockdown has no significant effect. This study provides new insights into the mechanisms of uterine vascular adaptation to pregnancy through RyR subtypes.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Shanna Hamilton, Radmila Terentyeva, Fruzsina Perger, Benjamin Hernandez Orengo, Benjamin Martin, Matthew W. Gorr, Andriy E. Belevych, Richard T. Clements, Sandor Gyorke, Dmitry Terentyev
Summary: The study explores the effects of enhancing mitochondrial calcium uptake in heart failure and diabetic cardiomyopathy, showing potential benefits for improving contractility but also increasing proarrhythmic events. It highlights the importance of balancing mitochondrial calcium concentration to protect against adverse effects and the role of mitochondrial ROS in disease-related arrhythmias.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cell Biology
Carlo Reggiani
Summary: Caffeine's ergogenic effects are not achieved through direct action on muscles, but by exerting a powerful effect on the sarcoplasmic reticulum at high concentrations, making it a valuable tool for studying SR function and diagnosing muscle disorders.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2021)
Article
Neurosciences
Xianwei Zhang, Charlotte E. R. Smith, Stefano Morotti, Andrew G. Edwards, Daisuke Sato, William E. Louch, Haibo Ni, Eleonora Grandi
Summary: This study investigates the independent and interactive effects of TATS and Ca2+-handling protein remodelling on Ca2+-handling abnormality driven membrane instabilities. The results show that the impact of protein remodelling on Ca2+-driven proarrhythmic behaviour varies depending on TATS density.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemistry & Molecular Biology
Candela Gonzalez-Arias, Andrea Sanchez-Ruiz, Julio Esparza, Cristina Sanchez-Puelles, Lucia Arancibia, Jorge Ramirez-Franco, Davide Gobbo, Frank Kirchhoff, Gertrudis Perea
Summary: This study reveals the altered astrocytic Ca2+ signaling in Major Depressive Disorder (MDD) and its impact on brain circuits and behavior. Boosting the astrocyte Ca2+ signaling can restore mood and cognitive abilities in MDD mice.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Jun Nakamura, Yuusuke Maruyama, Genichi Tajima, Yuto Komeiji, Makiko Suwa, Chikara Sato
Summary: The Ca2+-transport ATPase of sarcoplasmic reticulum is proposed to have calcium-sensitive membrane-endoskeleton characteristics, forming tetramers crystallized into cylindrical helical arrays under low Ca2+ concentrations, which disappear but leave SR protrusions under high Ca2+ concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jun Nakamura, Yuusuke Maruyama, Genichi Tajima, Satoshi Hayakawa, Makiko Suwa, Chikara Sato
Summary: The crystallization of Ca2+-ATPase molecules in sarcoplasmic reticulum vesicles is dependent on the concentration of Ca2+ ions, with ATP stabilizing the crystals. By using negative stain electron microscopy, it was observed that the length of SR vesicles is dependent on the [Ca2+] in the presence of ATP, with elongation occurring at <= 1.4 μM Ca2+ and contraction at >= 18 μM Ca2+. The crystallization of ATPase at high Ca2+ concentrations suggests a role in modulating the physical properties of SR architecture and muscle contraction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cell Biology
Grace E. Stutzmann
Summary: The calcium hypothesis of aging has been a consistent factor in the etiology of Alzheimer's disease since the early 1990s. Recent research has highlighted the role of intracellular calcium dysregulation and the elusive ryanodine receptor-2 isoform in AD pathogenesis.
Article
Neurosciences
Andrew J. Kesner, Yolanda Mateo, Karina P. Abrahao, Stephanie Ramos-Maciel, Matthew J. Pava, Alexa L. Gracias, Riley T. Paulsen, Hartley B. Carlson, David M. Lovinger
Summary: Withdrawal symptoms are observed in humans upon cessation of cannabis use. This study investigates the changes in striatal dopamine release, sleep disturbances, and behavioral adaptations during THC abstinence in a chronic THC-exposed mouse model. The findings suggest that THC affects dopamine release, sleep, and affect-related behaviors during withdrawal, with more consistent effects observed in male mice.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Cell Biology
M. Reichenstein, N. Borovok, A. Sheinin, T. Brider, I Michaelevski
Summary: Amyloid beta (Aβ) peptides are a key focus in Alzheimer's disease research, with varying effects depending on different molecular forms and experimental conditions. Recent studies suggest that the neurotoxic effects of Aβ peptides may be mediated through the activation of Abl kinases, potentially contributing to synaptic weakening.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuki Kawaguchi, Junpei Matsubayashi, Yutaka Kawakami, Ryohei Nishida, Yuji Kurihara, Kohtaro Takei
Summary: This study revealed that LOTUS improved A beta-induced synapse elimination by suppressing A beta-PirB interaction in rodents and inhibited A beta-LilrB2 interaction in humans. Our findings suggested that LOTUS may be a promising therapeutic agent in counteracting A beta-induced AD pathologies.
MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Rhys W. Livingstone, Megan K. Elder, Anurag Singh, Courteney M. Westlake, Warren P. Tate, Wickliffe C. Abraham, Joanna M. Williams
Summary: sAPP alpha enhances hippocampal LTP by promoting the cell-surface expression of GluA1 AMPARs and reducing GluA2 levels, affecting the localization and internalization of AMPARs at synapses, ultimately increasing synaptic levels of GluA1/2 AMPARs.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Critical Care Medicine
Charlene Supnet, April Crow, Sonja Stutzman, DaiWai Olson
CRITICAL CARE NURSE
(2016)
Article
Nursing
Amy L. Weaver, Sonja E. Stutzman, Charlene Supnet, DaiWai M. Olson
INTERNATIONAL EMERGENCY NURSING
(2016)
Article
Nursing
Lilian Omburo, Sonja Stutzman, Charlene Supnet, Mica Choate, DaiWai M. Olson
JOURNAL OF PERIANESTHESIA NURSING
(2017)
Review
Cell Biology
Charlene Supnet, Ilya Bezprozvanny
Article
Biochemistry & Molecular Biology
Xuesong Chen, Jun Wu, Yuan Luo, Xia Liang, Charlene Supnet, Mee Whi Kim, Gregor P. Lotz, Guocheng Yang, Paul J. Muchowski, Thomas Kodadek, Ilya Bezprozvanny
CHEMISTRY & BIOLOGY
(2011)
Article
Neurosciences
Omar Nelson, Charlene Supnet, Huarui Liu, Ilya Bezprozvanny
JOURNAL OF ALZHEIMERS DISEASE
(2010)
Article
Biochemistry & Molecular Biology
Omar Nelson, Charlene Supnet, Alexandra Tolia, Katrien Horre, Bart De Strooper, Ilya Bezprozvanny
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Letter
Biochemistry & Molecular Biology
Ilya Bezprozvanny, Charlene Supnet, Suya Sun, Hua Zhang, Bart De Strooper
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Neurosciences
Xi Chen, Jun Wu, Svetlana Lvovskaya, Emily Herndon, Charlene Supnet, Ilya Bezprozvanny
MOLECULAR NEURODEGENERATION
(2011)
Review
Biology
Charlene Supnet, Ilya Bezprozvanny
SCIENCE CHINA-LIFE SCIENCES
(2011)
Article
Medicine, Research & Experimental
ShannonB Juengst, Charlene Supnet, Chung Lin Novelle Kew, Valeria Silva, Marlene Vega, Gang Han, Brendan Kelley, Matthew Lee Smith, Gladys Maestre
Summary: This research aims to test the effectiveness of Problem-Solving Training (PST) for caregivers of individuals with Alzheimer's disease and related dementias, and determine the optimal number of sessions and boosters needed. The study will compare the efficacy of different numbers of PST sessions in reducing caregiver burden and depression, and identify key factors influencing the effectiveness of PST. The results will establish guidelines for a culturally-adapted problem-solving intervention to improve caregiver health and well-being.
CONTEMPORARY CLINICAL TRIALS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Charles Chen, Austin McCullough, Brian Gordon, Nelly Joseph-Mathurin, Shaney S. Flores, Nicole A. McKay, Diana Hobbs, Russ M. Hornbeck, Anne Fagan, Carlos M. Cruchaga, Alison J. Goate, Richard Perrin, Guoqiao Wang, Yan Li, Xinyu Shi, Chengjie J. Xiong, Michael Pontecorvo, Gregory Klein, Yi E. Su, William Klunk, Clifford Jack, Robert Koeppe, B. Joy B. Snider, Sarah D. Berman, Erik Roberson, Jared Brosch, Ghulam Z. Surti, Ivonne Jimenez-Velazquez, Douglas S. Galasko, Lawrence S. Honig, William Brooks, Roger Clarnette, David Wallon, Bruno Dubois, Jeremie Pariente, Florence Pasquier, Raquel Sanchez-Valle, Sergey Shcherbinin, Ixavier Higgins, Ilke L. Tunali, Colin H. Masters, Christopher van Dyck, Mario Masellis, Robin Hsiung, Serge Gauthier, Steve B. Salloway, David Clifford, Susan Mills, Charlene Supnet-Bell, Eric J. McDade, Randall Bateman, Tammie L. S. Benzinger
Summary: This study compared the efficacy of C-11-PiB and F-18-florbetapir radiotracers in Alzheimer's disease patients. The study found differences in A beta clearance between the two radiotracers, which could be harmonized using Centiloids. The study suggests considering the variability of different radiotracers in multisite studies and using a single radiotracer if feasible for the best results.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Clinical Neurology
Tonia Sabo, Charlene Supnet, Sushmita Purkayastha
CHILDS NERVOUS SYSTEM
(2018)
Article
Nursing
Sonja Stutzman, DaiWai Olson Phd, Charlene Supnet, Caryn Harper, Shelley Brown-Cleere, Becky McCulley, Mark Goldberg
JOURNAL OF NURSING ADMINISTRATION
(2016)