TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production

Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons

(2014) K Griesi-Oliveira et al.   MOLECULAR PSYCHIATRY

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKII  in Rat Hippocampal Neurons

(2012) Z. He et al.   JOURNAL OF NEUROSCIENCE

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

(2012) Katherine L Youmans et al.   Molecular Neurodegeneration

Opposite regulatory effects of TRPC1 and TRPC5 on neurite outgrowth in PC12 cells

(2011) Dae Keon Heo et al.   CELLULAR SIGNALLING

The physiology of the β-amyloid precursor protein intracellular domain AICD

(2011) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF NEUROCHEMISTRY

Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice

(2011) Ping Gong et al.   Molecular Neurodegeneration

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis

(2010) Lin Teng et al.   CELL RESEARCH

TRPM6 and TRPM7: A Mul-TRP-PLIK-Cation of Channel Functions

(2010) Loren W. Runnels   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats

(2010) Wanlu Du et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma

(2010) Xia Ding et al.   JNCI-Journal of the National Cancer Institute

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

(2010) Gen He et al.   NATURE

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Synaptic NMDA Receptor Activation Stimulates  -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-  Production

(2009) S. E. Hoey et al.   JOURNAL OF NEUROSCIENCE

The Orphan G Protein-Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons

(2009) A. Thathiah et al.   SCIENCE

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk

(2008) Ute Dreses-Werringloer et al.   CELL

Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions

(2008) Toshiharu Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests

(2008) K A Bates et al.   MOLECULAR PSYCHIATRY

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE

Critical role of TRPC6 channels in the formation of excitatory synapses

(2008) Jian Zhou et al.   NATURE NEUROSCIENCE

Functional roles of TRPC channels in the developing brain

(2008) Yilin Tai et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY