Article
Engineering, Environmental
Xiangyu Wang, Hanjiang Zhao, Zhenchuan Liu, Yitong Wang, Dan Lin, Long Chen, Jiewen Dai, Kaili Lin, Steve G. Shen
Summary: PDA nanoparticles exhibit a dual antioxidative and anti-inflammatory mechanism, effectively treating temporomandibular joint osteoarthritis by improving mitochondrial respiration efficiency and reducing ROS production. This nanoplatform opens up a new avenue for osteoarthritis treatment and offers valuable insights into the design of biomaterials with multiple biomedical applications by regulating cellular energy metabolism.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Chris Lindsay, Maria Musgaard, Angela J. Russell, Rebecca Sitsapesan
Summary: This study found that all the statins examined could activate RyR1, and cerivastatin was the most potent in activating RyR1, supporting the hypothesis that RyR1 activation is implicated in statin-induced myopathy. Several statin analogues were identified that retained HMG-CoA reductase inhibition but lacked the ability to modulate RyR1.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Isabelle Marty, Mathilde Beaufils, Julien Faure, John Rendu
Summary: Myopathies associated with RYR1 gene variations are genetic disorders with limited treatment options. The large size and wide distribution of variations along the sequence make it challenging to develop effective therapies. However, advancements in gene therapy and gene editing tools provide potential solutions at the mRNA and DNA levels. Promising results have been obtained in in vitro and in vivo studies, and inspiration can be drawn from other genetic diseases for the development of novel gene editing techniques.
CURRENT OPINION IN PHARMACOLOGY
(2023)
Article
Biology
Alexis Ruiz, Sofia Benucci, Urs Duthaler, Christoph Bachmann, Martina Franchini, Faiza Noreen, Laura Pietrangelo, Feliciano Protasi, Susan Treves, Francesco Zorzato
Summary: Currently, there are no therapies available for patients with congenital myopathies, which greatly affects their quality of life. However, a recent study found that targeting epigenetic enzymes with drugs can improve muscle strength and ultrastructure in mice with certain RYR1 gene mutations. This provides a proof of concept for potential pharmacological treatment of patients with congenital myopathies linked to recessive RYR1 mutations.
Review
Cell Biology
Shuji Wakatsuki, Toshiyuki Araki
Summary: Neurite degeneration, a self-destructive process, is a major component of neurodegenerative diseases induced by oxidative stress. The mechanism and signaling pathways of oxidative stress-induced neurite degeneration have been unknown. This review focuses on the phosphorylation-dependent regulation of the molecular interaction between ZNRF1 and the NADPH oxidase complex in reactive oxygen species-induced neurite degeneration.
NEURAL REGENERATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Raquel Gomez-Oca, Belinda S. Cowling, Jocelyn Laporte
Summary: Centronuclear myopathies (CNM) are rare congenital disorders characterized by muscle weakness and structural defects caused by mutations in genes encoding proteins involved in membrane remodeling, trafficking, and excitation-contraction coupling. Animal models have confirmed shared pathological anomalies in T-tubule remodeling, organelle mispositioning, and protein homeostasis, supporting the development of common therapeutic targets for CNM forms. Promising preclinical results have led to ongoing clinical trials for CNM treatment, including gene therapy and repurposing of existing drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Jiahui Zhao, Lianyun Lin, Hadiatullah Hadiatullah, Wei Chen, Jingmei Huang, Shunfan Wu, Takashi Murayama, Zhiguang Yuchi
Summary: Ryanodine receptor (RyR) is used as a target for insecticides, but resistance mutations have limited their effectiveness. This study investigated the activity of diamide insecticides against resistant RyRs in insects and mammals, and identified effective insecticides against resistant pests.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Immunology
Erandi Perez-Figueroa, Pablo Alvarez-Carrasco, Enrique Ortega
Summary: CD13 is a cell membrane ectopeptidase highly expressed in myeloid cells. It regulates the activity of bioactive peptides and can activate signal transduction pathways to mediate effector functions such as phagocytosis, ROS production, release of neutrophil extracellular traps, and cytokine secretion in neutrophils.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xujie Liu, Suya Wang, Xiaoling Guo, Yifei Li, Roza Ogurlu, Fujian Lu, Maksymilian Prondzynski, Sofia de la Serna Buzon, Qing Ma, Donghui Zhang, Gang Wang, Justin Cotton, Yuxuan Guo, Ling Xiao, David J. Milan, Yang Xu, Michael Schlame, Vassilios J. Bezzerides, William T. Pu
Summary: The study identified a molecular pathway linking TAZ mutation with abnormal Ca2+ handling and decreased cardiomyocyte contractility, offering potential therapeutic opportunities for treating Barth syndrome and other diseases with elevated mitochondrial reactive oxygen species production.
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Multidisciplinary Sciences
Fujian Lu, Qing Ma, Wenjun Xie, Carter L. Liou, Donghui Zhang, Mason E. Sweat, Blake D. Jardin, Francisco J. Naya, Yuxuan Guo, Heping Cheng, William T. Pu
Summary: This study uncovers the role of CMYA5 in organizing and regulating the subcellular structures in cardiomyocytes, highlighting its importance in cardiac development, function, and tolerance to pressure overload.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Juan Xie, Penghui Bai, Chenjie Wang, Ning Chen, Weifeng Chen, Ming Duan, Hu Wang
Summary: This study investigates the effect of doping SrTiO3 with an extremely low concentration of NiP on the catalytic activity of water splitting under visible light irradiation. It is found that the transformation of oxygen species and the construction of reactive lattice oxygen play a crucial role in improving the hydrogen generation performance. Adjusting the ratio of different oxygen species is an effective strategy to fabricate high-performance photocatalysts for H-2 evolution.
ACS APPLIED ENERGY MATERIALS
(2022)
Review
Engineering, Biomedical
Shiyong Zhang, Liying Wang, Yunze Kang, Jun Wu, Ziji Zhang
Summary: Reactive oxygen species (ROS) have significant roles in physiological and pathophysiological processes. Recent studies have shown that ROS plays a crucial role in the development and progression of osteoarthritis (OA) by mediating extracellular matrix degradation, mitochondrial dysfunction, chondrocyte apoptosis, and OA progression. Nanomaterials with ROS-scavenging ability and antioxidant effects have shown promising results in OA treatment. However, current research on nanomaterials as ROS scavengers for OA is not uniform, and the timing and potential of their clinical use remain inconsistent. This review aims to provide a reference for further studies and promote the early clinical use of nanomaterials for OA treatment.
ACTA BIOMATERIALIA
(2023)
Review
Pharmacology & Pharmacy
Angela F. Dulhunty, Lan Wei-LaPierre, Marco G. Casarotto, Nicole A. Beard
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Nicole C. Norris, Soumya Joseph, Shouvik Aditya, Yamuna Karunasekara, Philip G. Board, Angela F. Dulhunty, Aaron J. Oakley, Marco G. Casarotto
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Cell Biology
Spencer J. Richardson, Gregory A. Steele, Esther M. Gallant, Alexander Lam, Charles E. Schwartz, Philip G. Board, Marco G. Casarotto, Nicole A. Beard, Angela F. Dulhunty
JOURNAL OF CELL SCIENCE
(2017)
Article
Cardiac & Cardiovascular Systems
K. Walweel, P. Molenaar, M. S. Imtiaz, A. Denniss, C. dos Remedios, D. F. van Helden, A. F. Dulhunty, D. R. Laver, N. A. Beard
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2017)
Article
Pharmacology & Pharmacy
Amy D. Hanna, Alexander Lam, Chris Thekkedam, Hermia Willemse, Angela F. Dulhunty, Nicole A. Beard
MOLECULAR PHARMACOLOGY
(2017)
Article
Cell Biology
Claudio F. Perez, Jose M. Eltit, Jose R. Lopez, Dora Bodnar, Angela F. Dulhunty, Shouvik Aditya, Marco G. Casarotto
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2018)
Article
Chemistry, Medicinal
Ken Robinson, Christopher J. Easton, Angela F. Dulhunty, Marco G. Casarotto
Article
Pharmacology & Pharmacy
A. D. Chakraborty, L. A. Gonano, M. L. Munro, L. J. Smith, C. Thekkedam, V. Staudacher, A. B. Gamble, N. Macquaide, A. F. Dulhunty, P. P. Jones
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Cell Biology
Samantha C. Salvage, Esther M. Gallant, Nicole A. Beard, Shiraz Ahmad, Haseeb Valli, James A. Fraser, Christopher L. -H. Huang, Angela F. Dulhunty
JOURNAL OF CELL SCIENCE
(2019)
Article
Physiology
Samantha C. Salvage, Christopher L. -H. Huang, James A. Fraser, Angela F. Dulhunty
Summary: Flecainide, an antiarrhythmic drug, can reduce calcium ion release in the heart through multiple molecular mechanisms. It plays an important role in the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT).
JOURNAL OF GENERAL PHYSIOLOGY
(2022)
Review
Biology
Samantha C. C. Salvage, Angela F. F. Dulhunty, Kamalan Jeevaratnam, Antony P. P. Jackson, Christopher L. -H. Huang
Summary: Skeletal and cardiac muscle excitation-contraction coupling involves the interaction between Na(v)1.4/Na(v)1.5 and Cav1.1/Cav1.2 channels, as well as RyR1/RyR2 receptors, mediated by SR Ca2+ release. Studies have shown the potential feedback actions of SR Ca2+ release on Na(v)1.4/Na(v)1.5 function. Experimental observations have revealed the effects of RyR inhibitors and activators on Na+ currents in muscle fibers and cardiomyocytes. The modulation of Ca2+ transients and AP conduction has implications for arrhythmogenicity.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Biology
S. J. Richardson, C. G. Thekkedam, M. G. Casarotto, N. A. Beard, A. F. Dulhunty
Summary: Cardiac ryanodine receptors (RyR2) play a crucial role in releasing intracellular calcium essential for cardiac myocyte contraction. The regulation of ion channel opening by intracellular factors, including FK506 binding proteins FKBP12 and FKBP12.6, and their impact on RyR2 activity and cardiac contraction are still debated. This study demonstrates that FKBP12 activates RyR2 with high affinity and inhibits RyR2 with lower affinity, suggesting a model of negative cooperativity in FKBP12 binding. The dissociation of FKBP12/12.6 could dynamically affect RyR2 activity, indicating the significant role of FKBP12/12.6 in Ca2+ signaling and cardiac function.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Biophysics
Angela F. Dulhunty
Summary: The discovery of gating currents and asymmetric charge movement in the early 1970s has greatly advanced our understanding of the biophysical basis of voltage-dependent events in nerve and muscle function. The detection of these currents and charge movement has been crucial in unraveling the molecular and intra-molecular processes underlying action potentials and excitation-contraction coupling in excitable tissues.
BIOPHYSICAL REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Samantha C. Salvage, Karthik H. Chandrasekharan, Kamalan Jeevaratnam, Angela F. Dulhunty, Andrew J. Thompson, Antony P. Jackson, Christopher L-H Huang
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)