On the Role of Store-Operated Calcium Entry in Acute and Chronic Neurodegenerative Diseases

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

(2018) Ekaterina Pchitskaya et al.   CELL CALCIUM

Huntington's disease: a clinical review

(2017) P. McColgan et al.   EUROPEAN JOURNAL OF NEUROLOGY

Fast Ca2+ responses in astrocyte end-feet and neurovascular coupling in mice

(2017) Barbara Lykke Lind et al.   GLIA

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor

(2017) Renaud Bussiere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytes drive cortical vasodilatory signaling by activating endothelial NMDA receptors

(2017) Lingling Lu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of L-Type Ca 2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons

(2017) Yuyang Sun et al.   JOURNAL OF NEUROSCIENCE

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

(2017) Daniel Ryskamp et al.   NEUROBIOLOGY OF DISEASE

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

(2017) Martin Vaeth et al.   Nature Communications

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease

(2017) Xin Wang et al.   Frontiers in Molecular Neuroscience

The Regulation of Tumor Cell Invasion and Metastasis by Endoplasmic Reticulum-to-Mitochondrial Ca2+ Transfer

(2017) Carl White   Frontiers in Oncology

Homer binds to Orai1 and TRPC channels in the neointima and regulates vascular smooth muscle cell migration and proliferation

(2017) Shuping Jia et al.   Scientific Reports

The role of STIM and ORAI proteins in phagocytic immune cells

(2016) Nicolas Demaurex et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A nonsense mutation of Stim1 identified in stroke-prone spontaneously hypertensive rats decreased the store-operated calcium entry in astrocytes

(2016) Hiroki Ohara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular modulators of store-operated calcium entry

(2016) Jose J. Lopez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways

(2016) Stephen P. Duggan et al.   CELLULAR SIGNALLING

CardiacStim1Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt SignalingCLINICAL PERSPECTIVE

(2016) Ludovic Bénard et al.   CIRCULATION

Disruption of immune cell function by mutant huntingtin in Huntington's disease pathogenesis

(2016) Ralph Andre et al.   CURRENT OPINION IN PHARMACOLOGY

Editorial overview: Neurosciences: Brain and immunity: new targets for neuroprotection

(2016) Diana Amantea   CURRENT OPINION IN PHARMACOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model

(2016) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment

(2016) Hua Zhang et al.   JOURNAL OF NEUROSCIENCE

The role of the store-operated calcium entry channel Orai1 in cultured rat hippocampal synapse formation and plasticity

(2016) Eduard Korkotian et al.   JOURNAL OF PHYSIOLOGY-LONDON

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Purinergic signalling in brain ischemia

(2016) Felicita Pedata et al.   NEUROPHARMACOLOGY

Therapeutic strategies for Alzheimer's disease in clinical trials

(2016) Justyna Godyń et al.   Pharmacological Reports

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease

(2016) Qingde Zhou et al.   Nature Communications

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

Diseases caused by mutations inORAI1andSTIM1

(2015) Rodrigo S. Lacruz et al.   Annals of the New York Academy of Sciences

TRPC3 channels critically regulate hippocampal excitability and contextual fear memory

(2015) Sarah M. Neuner et al.   BEHAVIOURAL BRAIN RESEARCH

SOCE in neurons: Signaling or just refilling?

(2015) Lukasz Majewski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

STIM and ORAI proteins in the nervous system

(2015) Robert Kraft   Channels

Store-Operated Calcium Entry through Orai Is Required for Transcriptional Maturation of the Flight Circuit in Drosophila

(2015) Trayambak Pathak et al.   JOURNAL OF NEUROSCIENCE

Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease

(2015) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

(2015) Elena Popugaeva et al.   Molecular Neurodegeneration

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Stim and Orai proteins in neuronal Ca2+ signaling and excitability

(2015) Francesco Moccia et al.   Frontiers in Cellular Neuroscience

ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad

(2015) Anjoscha Kaus et al.   Frontiers in Cellular Neuroscience

TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production

(2015) Junfeng Wang et al.   Nature Communications

Inside-out Ca2+ signalling prompted by STIM1 conformational switch

(2015) Guolin Ma et al.   Nature Communications

Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes

(2015) Gisela Garcia-Alvarez et al.   Frontiers in Behavioral Neuroscience

Lack of GDAP1 Induces Neuronal Calcium and Mitochondrial Defects in a Knockout Mouse Model of Charcot-Marie-Tooth Neuropathy

(2015) Manuela Barneo-Muñoz et al.   PLoS Genetics

Rational modulation of the innate immune system for neuroprotection in ischemic stroke

(2015) Diana Amantea et al.   Frontiers in Neuroscience

Both Orai1 and TRPC1 are Involved in Excessive Store-Operated Calcium Entry in Striatal Neurons Expressing Mutant Huntingtin Exon 1

(2015) Vladimir Vigont et al.   Frontiers in Physiology

Angiotensin II type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with myocardial infarction-induced heart failure

(2014) Kengo Isegawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Emergence of Orai3 activity during cardiac hypertrophy

(2014) Youakim Saliba et al.   CARDIOVASCULAR RESEARCH

Calcium signaling in Parkinson’s disease

(2014) Tito Calì et al.   CELL AND TISSUE RESEARCH

Differential deregulation of astrocytic calcium signalling by amyloid-β, TNFα, IL-1β and LPS

(2014) Virginia Ronco et al.   CELL CALCIUM

Calcium Ion – The Key Player in Cerebral Ischemia

(2014) V.S. Kumar et al.   CURRENT MEDICINAL CHEMISTRY

Understanding the Multifaceted Role of Inflammatory Mediators in Ischemic Stroke

(2014) D. Amantea et al.   CURRENT MEDICINAL CHEMISTRY

Endothelial Remodelling and Intracellular Calcium Machinery

(2014) F. Moccia et al.   CURRENT MOLECULAR MEDICINE

An update on Huntingtonʼs disease

(2014) Samuel D. Kim et al.   CURRENT OPINION IN NEUROLOGY

Knockdown of STIM1 inhibits 6-hydroxydopamine-induced oxidative stress through attenuating calcium-dependent ER stress and mitochondrial dysfunction in undifferentiated PC12 cells

(2014) B. Li et al.   FREE RADICAL RESEARCH

STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia

(2014) Marlen Michaelis et al.   GLIA

Abnormal Intracellular Calcium Signaling and SNARE-Dependent Exocytosis Contributes to SOD1G93A Astrocyte-Mediated Toxicity in Amyotrophic Lateral Sclerosis

(2014) H. Kawamata et al.   JOURNAL OF NEUROSCIENCE

Suppression of InsP3 Receptor-Mediated Ca2+ Signaling Alleviates Mutant Presenilin-Linked Familial Alzheimer's Disease Pathogenesis

(2014) D. Shilling et al.   JOURNAL OF NEUROSCIENCE

Ryanodine receptors: physiological function and deregulation in Alzheimer disease

(2014) Dolores Del Prete et al.   Molecular Neurodegeneration

Contribution of TRPC3 to Store-Operated Calcium Entry and Inflammatory Transductions in Primary Nociceptors

(2014) Hazim Alkhani et al.   Molecular Pain

Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

(2014) Suya Sun et al.   NEURON

Suppression of STIM1 in the early stage after global ischemia attenuates the injury of delayed neuronal death by inhibiting store-operated calcium entry-induced apoptosis in rats

(2014) Ming Zhang et al.   NEUROREPORT

What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

(2014) Anders M. Fjell et al.   PROGRESS IN NEUROBIOLOGY

Found in Translation

(2014) Ulrich Dirnagl et al.   STROKE

Analysis of calcium homeostasis in fresh lymphocytes from patients with sporadic Alzheimer's disease or mild cognitive impairment

(2013) Anna Jaworska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ca 2+ spiking activity caused by the activation of store-operated Ca 2+ channels mediates TNF-α release from microglial cells under chronic purinergic stimulation

(2013) Masayuki Ikeda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

(2013) Shreaya Chakroborty et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ca2+Influx through Store-operated Ca2+Channels Reduces Alzheimer Disease β-Amyloid Peptide Secretion

(2013) William Zeiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral neuropathy in mitochondrial disorders

(2013) Davide Pareyson et al.   LANCET NEUROLOGY

Silencing of the Charcot–Marie–Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry

(2013) David Pla-Martín et al.   NEUROBIOLOGY OF DISEASE

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protective Effects of SKF-96365, a Non-Specific Inhibitor of SOCE, against MPP+-Induced Cytotoxicity in PC12 Cells: Potential Role of Homer1

(2013) Tao Chen et al.   PLoS One

Inhibition of Store-Operated Calcium Entry Attenuates MPP+-Induced Oxidative Stress via Preservation of Mitochondrial Function in PC12 Cells: Involvement of Homer1a

(2013) Xia Li et al.   PLoS One

Regulators of Calcium Homeostasis Identified by Inference of Kinetic Model Parameters from Live Single Cells Perturbed by siRNA

(2013) S. Bandara et al.   Science Signaling

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Antithrombotic Potential of Blockers of Store-Operated Calcium Channels in Platelets

(2012) Roger van Kruchten et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Role of ER Stress-Induced Apoptosis in Neurodegeneration

(2012) Ioanna C. Stefani et al.   Current Alzheimer Research

Cholesterol loss during glutamate-mediated excitotoxicity

(2012) Alejandro O Sodero et al.   EMBO JOURNAL

Response to Shillinget al.(10.1074/jbc.M111.300491)

(2012) Ilya Bezprozvanny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels

(2012) Dustin Shilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling

(2012) Senthil Selvaraj et al.   JOURNAL OF CLINICAL INVESTIGATION

A New Concept: A 1-42 Generates a Hyperfunctional Proteolytic NCX3 Fragment That Delays Caspase-12 Activation and Neuronal Death

(2012) A. Pannaccione et al.   JOURNAL OF NEUROSCIENCE

Ryanodine Receptor Blockade Reduces Amyloid-  Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

(2012) B. Oules et al.   JOURNAL OF NEUROSCIENCE

Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

(2012) Jun Peng et al.   NEUROSCIENCE LETTERS

Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease

(2012) Shreaya Chakroborty et al.   PLoS One

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein

(2011) Cristina I. Linde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Immunodeficiency due to defects in store-operated calcium entry

(2011) Stefan Feske   Annals of the New York Academy of Sciences

Neuronal Store-Operated Calcium Entry Pathway as a Novel Therapeutic Target for Huntington's Disease Treatment

(2011) Jun Wu et al.   CHEMISTRY & BIOLOGY

Critical Role for Stromal Interaction Molecule 1 in Cardiac Hypertrophy

(2011) Jean-Sébastien Hulot et al.   CIRCULATION

Orai1-Mediated I CRAC Is Essential for Neointima Formation After Vascular Injury

(2011) Wei Zhang et al.   CIRCULATION RESEARCH

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore

(2011) Omar Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis

(2011) F. AHMAD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis

(2011) Y.-F. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels

(2010) Moonhee Lee et al.   BRAIN RESEARCH

EFNS guidelines for the diagnosis and management of Alzheimer’s disease

(2010) J. Hort et al.   EUROPEAN JOURNAL OF NEUROLOGY

S-glutathionylation activates STIM1 and alters mitochondrial homeostasis

(2010) Brian J. Hawkins et al.   JOURNAL OF CELL BIOLOGY

Role of Presenilins in Neuronal Calcium Homeostasis

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Store-operated CRAC channels: function in health and disease

(2010) Anant B. Parekh   NATURE REVIEWS DRUG DISCOVERY

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration

(2009) Marie Potier et al.   FASEB JOURNAL

Neuroprotective Effects of Inositol 1,4,5-Trisphosphate Receptor C-Terminal Fragment in a Huntington's Disease Mouse Model

(2009) T.-S. Tang et al.   JOURNAL OF NEUROSCIENCE

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

(2009) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death

(2009) A. Berna-Erro et al.   Science Signaling

Anoxia-Induced NF-kB-Dependent Upregulation of NCX1 Contributes to Ca 2+ Refilling Into Endoplasmic Reticulum in Cortical Neurons

(2009) Rossana Sirabella et al.   STROKE

Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

(2008) John J. Mieyal et al.   ANTIOXIDANTS & REDOX SIGNALING

Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease

(2008) Lukasz Bojarski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation

(2008) A. Braun et al.   BLOOD

The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein–protein interaction

(2008) Volodya Hayrapetyan et al.   CELL CALCIUM

Memantine Potentiates Agonist-Induced Ca2+ Responses in HEK 293 Cells

(2008) Alexandre Blanchard et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Stromal Interaction Molecule (STIM) 1 and STIM2 Calcium Sensing Regions Exhibit Distinct Unfolding and Oligomerization Kinetics

(2008) Peter B. Stathopulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

(2008) Kim N. Green et al.   JOURNAL OF CELL BIOLOGY

The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction

(2008) David Varga-Szabo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

(2008) P. Cassina et al.   JOURNAL OF NEUROSCIENCE

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

(2008) Masatsugu Oh-hora et al.   NATURE IMMUNOLOGY

Critical role of TRPC6 channels in the formation of excitatory synapses

(2008) Jian Zhou et al.   NATURE NEUROSCIENCE

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Methylprednisolone treatment delays remote cell death after focal brain lesion

(2008) M.T. Viscomi et al.   NEUROSCIENCE