The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model

Regulation of Memory Formation by the Transcription Factor XBP1

(2016) Gabriela Martínez et al.   Cell Reports

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

(2014) P. Valdes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease

(2014) Lluís Pujadas et al.   Nature Communications

Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease

(2013) Sven Reinhardt et al.   FASEB JOURNAL

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1

(2013) E. Duplan et al.   JOURNAL OF CELL SCIENCE

Postsynaptic Density Scaffold SAP102 Regulates Cortical Synapse Development through EphB and PAK Signaling Pathway

(2013) Y. Murata et al.   JOURNAL OF NEUROSCIENCE

Targeting the endocannabinoid system in the treatment of fragile X syndrome

(2013) Arnau Busquets-Garcia et al.   NATURE MEDICINE

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Environmental Novelty Activates β2-Adrenergic Signaling to Prevent the Impairment of Hippocampal LTP by Aβ Oligomers

(2013) Shaomin Li et al.   NEURON

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington’s disease

(2012) Amparo Zuleta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

(2012) Eva M Jimenez-Mateos et al.   NATURE MEDICINE

β-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis

(2012) Patrick S. Murray et al.   NEUROBIOLOGY OF AGING

Kalirin, a Key Player in Synapse Formation, Is Implicated in Human Diseases

(2012) Prashant Mandela et al.   NEURAL PLASTICITY

Kalrn promoter usage and isoform expression respond to chronic cocaine exposure

(2011) Richard E Mains et al.   BMC NEUROSCIENCE

EphB Controls NMDA Receptor Function and Synaptic Targeting in a Subunit-Specific Manner

(2011) M. J. Nolt et al.   JOURNAL OF NEUROSCIENCE

Kalirin Binds the NR2B Subunit of the NMDA Receptor, Altering Its Synaptic Localization and Function

(2011) D. D. Kiraly et al.   JOURNAL OF NEUROSCIENCE

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Emerging Roles for XBP1, a sUPeR Transcription Factor

(2010) YIN HE et al.   GENE EXPRESSION

P2Y2 Nucleotide Receptor-Mediated Responses in Brain Cells

(2010) Troy S. Peterson et al.   MOLECULAR NEUROBIOLOGY

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

(2010) Moustapha Cissé et al.   NATURE

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

(2010) Akiko Hayashi-Takagi et al.   NATURE NEUROSCIENCE

Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The α-Secretase-derived N-terminal Product of Cellular Prion, N1, Displays Neuroprotective Functionin Vitroandin Vivo

(2009) Marie-Victoire Guillot-Sestier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy

(2009) Yu-Dong Zhou et al.   NATURE MEDICINE

Amyloid beta from axons and dendrites reduces local spine number and plasticity

(2009) Wei Wei et al.   NATURE NEUROSCIENCE

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

(2008) Chiho Hirata-Fukae et al.   BRAIN RESEARCH

Regulation of Kalirin by Cdk5

(2008) X. Xin et al.   JOURNAL OF CELL SCIENCE

Kalirin-7 Is an Essential Component of both Shaft and Spine Excitatory Synapses in Hippocampal Interneurons

(2008) X.-M. Ma et al.   JOURNAL OF NEUROSCIENCE

Kalirin-7 Is Required for Synaptic Structure and Function

(2008) X.-M. Ma et al.   JOURNAL OF NEUROSCIENCE

Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion

(2008) Jun Mukai et al.   NATURE NEUROSCIENCE