Peptide Late-Stage Diversifications by Rhodium-Catalyzed Tryptophan C7 Amidation

Bidentate Directing Groups: An Efficient Tool in C–H Bond Functionalization Chemistry for the Expedient Construction of C–C Bonds

(2020) Supriya Rej et al.   CHEMICAL REVIEWS

C7‐Indole Amidations and Alkenylations by Ruthenium(II) Catalysis

(2020) Isaac Choi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Macrocyclization of peptidoarylacetamides with self-assembly properties through late-stage palladium-catalyzed C(sp2)▬H olefination

(2019) Jiantao Tan et al.   Science Advances

Ir-Catalyzed Intermolecular Branch-Selective Allylic C–H Amidation of Unactivated Terminal Olefins

(2019) Honghui Lei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intermolecular, Branch-Selective and Redox-Neutral Cp*IrIII-Catalyzed Allylic C-H Amidation

(2019) Tobias Knecht et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review

(2019) Erik Höglund et al.   Frontiers in Endocrinology

Glycopeptides by Linch‐Pin C−H Activations for Peptide‐Carbohydrate Conjugation by Manganese(I)‐Catalysis

(2019) Wei Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Peptide ligation by chemoselective aminonitrile coupling in water

(2019) Pierre Canavelli et al.   NATURE

Metal-free directed C–H bond activation and borylation

(2019) Jiahang Lv et al.   NATURE

α-Branched amines by catalytic 1,1-addition of C–H bonds and aminating agents to terminal alkenes

(2019) Soham Maity et al.   Nature Catalysis

Subtiligase-Catalyzed Peptide Ligation

(2019) Amy M. Weeks et al.   CHEMICAL REVIEWS

A new antibiotic selectively kills Gram-negative pathogens

(2019) Yu Imai et al.   NATURE

Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis

(2019) Alexandra Schischko et al.   Nature Communications

Advances in oral peptide therapeutics

(2019) Daniel J. Drucker   NATURE REVIEWS DRUG DISCOVERY

BODIPY Peptide Labeling by Late-Stage C(sp3 )−H Activation

(2018) Wei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Selective δ-C(sp3 )−H Alkylation of Amino Acids and Peptides with Maleimides via a Six-Membered Palladacycle

(2018) Bei-Bei Zhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late-Stage Peptide Diversification by Position-Selective C-H Activation

(2018) Wei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thiocarbonyl-enabled ferrocene C–H nitrogenation by cobalt(III) catalysis: thermal and mechanochemical

(2018) Santhivardhana Reddy Yetra et al.   Beilstein Journal of Organic Chemistry

Site-selective C-H Bond Activation/Functionalization on Alpha-Amino Acids and Peptide-like Derivatives

(2018) Tobias Brandhofer et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Organic synthesis provides opportunities to transform drug discovery

(2018) David C. Blakemore et al.   Nature Chemistry

Selective formation of γ-lactams via C–H amidation enabled by tailored iridium catalysts

(2018) Seung Youn Hong et al.   SCIENCE

Delineating Physical Organic Parameters in Site-Selective C–H Functionalization of Indoles

(2018) Youyoung Kim et al.   ACS Central Science

Rapid and efficient protein synthesis through expansion of the native chemical ligation concept

(2018) Sameer S. Kulkarni et al.   Nature Reviews Chemistry

Arylation Chemistry for Bioconjugation

(2018) Bradley Pentelute et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PIII -Chelation-Assisted Indole C7-Arylation, Olefination, Methylation, and Acylation with Carboxylic Acids/Anhydrides by Rhodium Catalysis

(2018) Xiaodong Qiu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late-Stage Diversification by Manganese-Catalyzed C-H Activation: Access to Acyclic, Hybrid and Stapled Peptides

(2018) Nikolaos Kaplaneris et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late-Stage Peptide Diversification through Cobalt-Catalyzed C−H Activation: Sequential Multicatalysis for Stapled Peptides

(2018) Mélanie M. Lorion et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Current State of Peptide Drug Discovery: Back to the Future?

(2017) Antoine Henninot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Late stage modification of peptides via C H activation reactions

(2017) Saumitra Sengupta et al.   TETRAHEDRON LETTERS

Stapled Peptides by Late-Stage C(sp3 )−H Activation

(2016) Anaïs F. M. Noisier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silicon-Containing Amino Acids: Synthetic Aspects, Conformational Studies, and Applications to Bioactive Peptides

(2016) Emmanuelle Rémond et al.   CHEMICAL REVIEWS

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

(2016) Jian He et al.   CHEMICAL REVIEWS

Iridium(III)-Catalyzed Regioselective C7-Amination of N-Pivaloylindoles with Sulfonoazides

(2016) Lanting Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

Why is the Ir(III)-Mediated Amido Transfer Much Faster Than the Rh(III)-Mediated Reaction? A Combined Experimental and Computational Study

(2016) Yoonsu Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium(iii)-catalyzed regioselective C7-sulfonamidation of indoles

(2016) Zengqiang Song et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Direct Access to 7-Aminoindoles via Iridium-Catalyzed Mild C–H Amidation of N-Pivaloylindoles with Organic Azides

(2016) Youyoung Kim et al.   ORGANIC LETTERS

Rhodium-Catalyzed Regioselective C7-Functionalization of N -Pivaloylindoles

(2015) Lanting Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink

(2015) Kelsey R. Schramma et al.   Nature Chemistry

New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues

(2015) Lorena Mendive-Tapia et al.   Nature Communications

Light-Induced Ruthenium-Catalyzed Nitrene Transfer Reactions: A Photochemical Approach towards N-Acyl Sulfimides and Sulfoximines

(2014) Vincent Bizet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C–H Functionalization in the Synthesis of Amino Acids and Peptides

(2014) Anaïs F. M. Noisier et al.   CHEMICAL REVIEWS

C7-Derivatization of C3-Alkylindoles Including Tryptophans and Tryptamines

(2014) Richard P. Loach et al.   JOURNAL OF ORGANIC CHEMISTRY

Site-Selective C(sp3)–H Functionalization of Di-, Tri-, and Tetrapeptides at the N-Terminus

(2014) Wei Gong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetic Incorporation of Multiple Unnatural Amino Acids into Proteins in Mammalian Cells

(2013) Han Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

(2013) Joanna Wencel-Delord et al.   Nature Chemistry

Rethinking amide bond synthesis

(2011) Vijaya R. Pattabiraman et al.   NATURE

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Oxidative Coupling of Aromatic Substrates with Alkynes and Alkenes under Rhodium Catalysis

(2010) Tetsuya Satoh et al.   CHEMISTRY-A EUROPEAN JOURNAL

Transition-Metal-Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage

(2009) Lutz Ackermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amino Acid-Protecting Groups

(2009) Albert Isidro-Llobet et al.   CHEMICAL REVIEWS

Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation

(2009) Denise A. Colby et al.   CHEMICAL REVIEWS

Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion

(2008) Huw M. L. Davies et al.   NATURE