Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate ofBurkholderia cenocepacia

Chemical Synthesis ofBurkholderiaLipid A Modified with Glycosyl Phosphodiester-Linked 4-Amino-4-deoxy-β-L-arabinose and Its Immunomodulatory Potential

(2015) Ralph Hollaus et al.   CHEMISTRY-A EUROPEAN JOURNAL

Modulation of Toll-Like Receptor 4. Insights from X-Ray Crystallography and Molecular Modeling

(2015) Javier Klett et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Bordetella pertussisLipid A Recognition by Toll-like Receptor 4 and MD-2 Is Dependent on Distinct Charged and Uncharged Interfaces

(2015) Nina Maeshima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity

(2015) Flaviana Di Lorenzo et al.   MOLECULAR IMMUNOLOGY

Chemistry of Lipid A: At the Heart of Innate Immunity

(2014) Antonio Molinaro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tetra- and Penta-Acylated Lipid A Structures of Porphyromonas gingivalis LPS Differentially Activate TLR4-Mediated NF-κB Signal Transduction Cascade and Immuno-Inflammatory Response in Human Gingival Fibroblasts

(2013) Thanuja D. K. Herath et al.   PLoS One

Recognition of lipid A variants by the TLR4-MD-2 receptor complex

(2013) Nina Maeshima et al.   Frontiers in Cellular and Infection Microbiology

MM-ISMSA: An Ultrafast and Accurate Scoring Function for Protein–Protein Docking

(2012) Javier Klett et al.   Journal of Chemical Theory and Computation

Aminoarabinose is essential for lipopolysaccharide export and intrinsic antimicrobial peptide resistance inBurkholderia cenocepacia†

(2012) Mohamad A. Hamad et al.   MOLECULAR MICROBIOLOGY

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MD-2 Residues Tyrosine 42, Arginine 69, Aspartic Acid 122, and Leucine 125 Provide Species Specificity for Lipid IVA

(2010) Jianmin Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glyco-conjugates as elicitors or suppressors of plant innate immunity

(2009) A. Silipo et al.   GLYCOBIOLOGY

Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin

(2009) Nuša Resman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis and Structure of theBurkholderia cenocepaciaK56-2 Lipopolysaccharide Core Oligosaccharide

(2009) Ximena Ortega et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE