Dual Role of Toll-like Receptors in Human and Experimental Asthma Models

TNF-α–induced protein 3 levels in lung dendritic cells instruct T H 2 or T H 17 cell differentiation in eosinophilic or neutrophilic asthma

(2018) Heleen Vroman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of endosomal toll-like receptors in asthma

(2017) Andriana I. Papaioannou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

IgG subclasses determine pathways of anaphylaxis in mice

(2017) Héloïse Beutier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TNF is required for TLR ligand–mediated but not protease-mediated allergic airway inflammation

(2017) Gregory S. Whitehead et al.   JOURNAL OF CLINICAL INVESTIGATION

CpG-ODN Shapes Alum Adjuvant Activity Signaling via MyD88 and IL-10

(2017) Luciana Cristina Mirotti et al.   Frontiers in Immunology

Interaction Between Helminths and Toll-Like Receptors: Possibilities and Potentials for Asthma Therapy

(2016) Amin Zakeri et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells

(2016) Jae-Uoong Shim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9

(2016) Linda M. Lee et al.   PLoS One

Immunoregulatory and immunostimulatory responses of bacterial lysates in respiratory infections and asthma

(2015) Sean Christopher Kearney et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

LPS exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea pig model of asthma

(2015) A P P Lowe et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential TLR-induced cytokine production by human mast cells is amplified by FcɛRI triggering

(2015) J. Suurmond et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Toll-like receptors: Activation, signalling and transcriptional modulation

(2015) Dominic De Nardo   CYTOKINE

Toll-like receptor signaling in parasitic infections

(2015) Dalia S Ashour   Expert Review of Clinical Immunology

Lipopolysaccharide challenge: immunological effects and safety in humans

(2015) Stefan Zielen et al.   Expert Review of Clinical Immunology

Treatment with 8-OH-modified adenine (TLR7 ligand)-allergen conjugates decreases T helper type 2-oriented murine airway inflammation

(2015) Francesca Nencini et al.   IMMUNOLOGY

House Dust Mite Allergen Regulates Constitutive Apoptosis of Normal and Asthmatic Neutrophils via Toll-Like Receptor 4

(2015) Do Hyung Kim et al.   PLoS One

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

(2015) M. J. Schuijs et al.   SCIENCE

Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia

(2015) Luke Hatchwell et al.   THORAX

Adsorption of Toll-Like Receptor 4 Agonist to Alum-Based Tetanus Toxoid Vaccine Dampens Pro-T Helper 2 Activities and Enhances Antibody Responses

(2015) Juliana Bortolatto et al.   Journal of Immunology Research

The evolution of the hygiene hypothesis

(2014) Denise Daley   Current Opinion in Allergy and Clinical Immunology

Protective phenotypes of club cells and alveolar macrophages are favored as part of endotoxin-mediated prevention of asthma

(2014) Luciana N García et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation

(2014) J. L. Johnson et al.   GLYCOBIOLOGY

Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy

(2014) H J McSorley et al.   Mucosal Immunology

Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation

(2014) J W McAlees et al.   Mucosal Immunology

Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-Analysis of Clinical Trials

(2014) V. Ta et al.   PEDIATRICS

Development of a Novel Severe Triple Allergen Asthma Model in Mice Which Is Resistant to Dexamethasone and Partially Resistant to TLR7 and TLR9 Agonist Treatment

(2014) Matthias J. Duechs et al.   PLoS One

Differential Effects of the Toll-Like Receptor 2 Agonists, PGN and Pam3CSK4 on Anti-IgE Induced Human Mast Cell Activation

(2014) Yangyang Yu et al.   PLoS One

Trafficking of endosomal Toll-like receptors

(2014) Bettina L. Lee et al.   TRENDS IN CELL BIOLOGY

The effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study

(2014) Füsun Şahin et al.   BMC Pulmonary Medicine

Epicutaneous immune modulation with Bet v 1 plus R848 suppresses allergic asthma in a murine model

(2013) S. Siebeneicher et al.   ALLERGY

Toll-like Receptor 7 Rapidly Relaxes Human Airways

(2013) Matthew G. Drake et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma

(2013) Elena Goleva et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mapping of TLR5 and TLR7 in central and distal human airways and identification of reduced TLR expression in severe asthma

(2013) M. M. Shikhagaie et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Induction of the specific allergic immune response is independent of proteases from the fungusAlternaria alternata

(2013) Olivier Denis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Activation of human basophils by combined toll-like receptor- and FcεRI-triggering can promote Th2 skewing of naive T helper cells

(2013) Jolien Suurmond et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma

(2013) Kai-Michael Beeh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergens as Immunomodulatory Proteins: The Cat Dander Protein Fel d 1 Enhances TLR Activation by Lipid Ligands

(2013) J. Herre et al.   JOURNAL OF IMMUNOLOGY

Endotoxin Exposure during Sensitization to Blomia tropicalis Allergens Shifts TH2 Immunity Towards a TH17-Mediated Airway Neutrophilic Inflammation: Role of TLR4 and TLR2

(2013) Renato Barboza et al.   PLoS One

TLR3, TLR4 and TLRs7–9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma

(2013) Annemarie Sykes et al.   PLoS One

Cleavage of Fibrinogen by Proteinases Elicits Allergic Responses Through Toll-Like Receptor 4

(2013) V. O. Millien et al.   SCIENCE

Pattern-recognition receptors in human eosinophils

(2012) Anne Månsson Kvarnhammar et al.   IMMUNOLOGY

Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study

(2012) Georg Loss et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanism of Action of Inhibition of Allergic Immune Responses by a Novel Antedrug TLR7 Agonist

(2012) H. Matsui et al.   JOURNAL OF IMMUNOLOGY

TLR3 but Not TLR7/8 Ligand Induces Allergic Sensitization to Inhaled Allergen

(2012) S. Reuter et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptor Activation during Cutaneous Allergen Sensitization Blocks Development of Asthma through IFN-Gamma-Dependent Mechanisms

(2012) Rita Haapakoski et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens

(2012) Rhonda H Wilson et al.   NATURE MEDICINE

A20 Regulation of Nuclear Factor–κB

(2011) Catriona Kelly et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Treatment with the TLR7 agonist R848 induces regulatory T-cell-mediated suppression of established asthma symptoms

(2011) Linh Pham Van et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The active contribution of Toll-like receptors to allergic airway inflammation

(2011) Keqiang Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A fusion protein of flagellin and ovalbumin suppresses the TH2 response and prevents murine intestinal allergy

(2011) Stefan Schülke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A

(2011) Ana Paula Moreira et al.   JOURNAL OF CLINICAL INVESTIGATION

The TLR7 Ligand 9-Benzyl-2-Butoxy-8-Hydroxy Adenine Inhibits IL-17 Response by Eliciting IL-10 and IL-10-Inducing Cytokines

(2011) A. Vultaggio et al.   JOURNAL OF IMMUNOLOGY

TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways

(2011) Matthias J. Duechs et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Allergen-specific pattern recognition receptor pathways

(2010) Marsha Wills-Karp   CURRENT OPINION IN IMMUNOLOGY

Use of defined TLR ligands as adjuvants within human vaccines

(2010) Malcolm S. Duthie et al.   IMMUNOLOGICAL REVIEWS

Toll-like Receptor Expression on Peripheral Blood Mononuclear Cells in Asthmatics; Implications for Asthma Management

(2010) Eunyoung Chun et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Double-Stranded RNA Exacerbates Pulmonary Allergic Reaction through TLR3: Implication of Airway Epithelium and Dendritic Cells

(2010) D. Torres et al.   JOURNAL OF IMMUNOLOGY

TLR4 Signaling in Stromal Cells Is Critical for the Initiation of Allergic Th2 Responses to Inhaled Antigen

(2010) A. M. Tan et al.   JOURNAL OF IMMUNOLOGY

TLR2 Agonists Enhance CD8+Foxp3+ Regulatory T Cells and Suppress Th2 Immune Responses during Allergen Immunotherapy

(2010) Y.-G. Tsai et al.   JOURNAL OF IMMUNOLOGY

The role of dendritic and epithelial cells as master regulators of allergic airway inflammation

(2010) Bart N Lambrecht et al.   LANCET

Fusion protein of TLR5-ligand and allergen potentiates activation and IL-10 secretion in murine myeloid DC

(2010) Stefan Schülke et al.   MOLECULAR IMMUNOLOGY

The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways

(2010) S Navarro et al.   Mucosal Immunology

Allergic Sensitization through the Airway Primes Th17-dependent Neutrophilia and Airway Hyperresponsiveness

(2009) Rhonda H. Wilson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Toll/IL-1 Signaling Is Critical for House Dust Mite–specific Th1 and Th2 Responses

(2009) Simon Phipps et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Toll-like receptor 7 function is reduced in adolescents with asthma

(2009) M. Roponen et al.   EUROPEAN RESPIRATORY JOURNAL

A Toll-Like Receptor 2/6 Agonist Reduces Allergic Airway Inflammation in Chronic Respiratory Sensitisation to Timothy Grass Pollen Antigens

(2009) Barbara Fuchs et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Different Doses of Lipopolysaccharides Regulate the Lung Inflammation of Asthmatic Mice via TLR4 Pathway in Alveolar Macrophages

(2009) Liang Dong et al.   JOURNAL OF ASTHMA

Vascular Endothelial Growth Factor Is a Key Mediator in the Development of T Cell Priming and Its Polarization to Type 1 and Type 17 T Helper Cells in the Airways

(2009) Y.-S. Kim et al.   JOURNAL OF IMMUNOLOGY

Intranasal Administration of CpG Induces a Rapid and Transient Cytokine Response Followed by Dendritic and Natural Killer Cell Activation and Recruitment in the Mouse Lung

(2009) Isabella Pesce et al.   Journal of Innate Immunity

Role of atopic status in Toll-like receptor (TLR)7- and TLR9-mediated activation of human eosinophils

(2009) A. Mansson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

Toll-like receptor 4 agonists adsorbed to aluminium hydroxide adjuvant attenuate ovalbumin-specific allergic airway disease: role of MyD88 adaptor molecule and interleukin-12/interferon-γ axis

(2008) J. Bortolatto et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2-polarizing conditions

(2008) J. Tanaka et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Toll-like receptors in the respiratory system: Their roles in inflammation

(2008) Chiaki Iwamura et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Toll like receptor-2 modulates both innate and adaptive immune responses during chronic fungal asthma in mice

(2008) K. F. Buckland et al.   INFLAMMATION RESEARCH

Toll-like receptor heterodimer variants protect from childhood asthma

(2008) Michael S.D. Kormann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression and Functional Analysis of Toll-Like Receptors of Peripheral Blood Cells in Asthmatic Patients: Implication for Immunopathological Mechanism in Asthma

(2008) Samantha W. M. Lun et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

(2008) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

(2008) Aurelien Trompette et al.   NATURE