Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics

Aminosugar-based immunomodulator lipid A: synthetic approaches

(2018) Alla Zamyatina   Beilstein Journal of Organic Chemistry

A caspase-independent way to kill cancer cells

(2017) Brent E. Fitzwalter et al.   NATURE CELL BIOLOGY

The influence of acceptor nucleophilicity on the glycosylation reaction mechanism

(2017) S. van der Vorm et al.   Chemical Science

Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery

(2017) Kelsey A. Gregg et al.   mBio

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

(2016) Ying Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating endotoxin activity by combinatorial bioengineering of meningococcal lipopolysaccharide

(2016) Afshin Zariri et al.   Scientific Reports

Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis

(2016) Guochao Liao et al.   ACS Central Science

Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity

(2015) Jieling Yang et al.   CURRENT OPINION IN IMMUNOLOGY

Biosynthetically engineered lipopolysaccharide as vaccine adjuvant

(2015) Afshin Zariri et al.   Expert Review of Vaccines

TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth

(2015) Svasti Haricharan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A fully synthetic self-adjuvanting globo H-Based vaccine elicited strong T cell-mediated antitumor immunity

(2015) Zhifang Zhou et al.   Chemical Science

WildCARDs: Inflammatory caspases directly detect LPS

(2014) Jon Alan Hagar et al.   CELL RESEARCH

Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold

(2014) Jose Antonio Garate et al.   Innate Immunity

Development of αGlcN(1↔1)αMan-Based Lipid A Mimetics as a Novel Class of Potent Toll-like Receptor 4 Agonists

(2014) Florian Adanitsch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Conformationally Constrained Lipid A Mimetics for Exploration of Structural Basis of TLR4/MD-2 Activation by Lipopolysaccharide

(2013) Daniel Artner et al.   ACS Chemical Biology

Immunotherapy for the Adjunctive Treatment of Sepsis: From Immunosuppression to Immunostimulation. Time for a Paradigm Change?

(2013) Jenneke Leentjens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inflammasomes and host defenses against bacterial infections

(2013) Gregory I Vladimer et al.   CURRENT OPINION IN MICROBIOLOGY

Detection of cytosolic bacteria by inflammatory caspases

(2013) Jon A Hagar et al.   CURRENT OPINION IN MICROBIOLOGY

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Inefficient TLR4/MD-2 Heterotetramerization by Monophosphoryl Lipid A

(2013) Carolyn R. Casella et al.   PLoS One

Modulating the innate immune response by combinatorial engineering of endotoxin

(2013) Brittany D. Needham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology

(2013) J.-P. Michaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing Endotoxins from Within

(2013) J. C. Kagan   SCIENCE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LPS remodeling is an evolved survival strategy for bacteria

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Glycosylation with glycosyl N-phenyltrifluoroacetimidates (PTFAI) and a perspective of the future development of new glycosylation methods

(2010) Biao Yu et al.   CHEMICAL COMMUNICATIONS

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Immunotherapy for Sepsis — A New Approach against an Ancient Foe

(2010) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increasing the Antigenicity of Synthetic Tumor-Associated Carbohydrate Antigens by Targeting Toll-Like Receptors

(2009) Sampat Ingale et al.   CHEMBIOCHEM

Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin

(2009) Nuša Resman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation

(2009) Jianmin Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

Mechanism of chemical O-glycosylation: from early studies to recent discoveries

(2009) Laurel K. Mydock et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

(2009) L. A. J. O'Neill et al.   PHARMACOLOGICAL REVIEWS

Host Innate Immune Receptors and Beyond: Making Sense of Microbial Infections

(2008) Ken J. Ishii et al.   Cell Host & Microbe

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

(2008) C. R. Casella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY