Sphingolipids in embryonic development, cell cycle regulation, and stemness – Implications for polyploidy in tumors

Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt

(2020) Stephanie Schwalm et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

B4GALNT1 induces angiogenesis, anchorage independence growth and motility, and promotes tumorigenesis in melanoma by induction of ganglioside GM2/GD2

(2020) Hideki Yoshida et al.   Scientific Reports

Tamoxifen is a candidate first‐in‐class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells—Unrecognized players in tumorigenesis

(2020) Shai White‐Gilbertson et al.   Cancer Medicine

Nuclear envelope dysfunction and its contribution to the aging process

(2020) Filipa Martins et al.   AGING CELL

Novel signaling aspects of ceramide 1-phosphate

(2020) Natalia Presa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ceramide launches an acute anti‐adhesion pro‐migration cell signaling program in response to chemotherapy

(2020) Daniel Canals et al.   FASEB JOURNAL

Lipid and protein dynamics that shape nuclear envelope identity

(2020) Shirin Bahmanyar et al.   MOLECULAR BIOLOGY OF THE CELL

Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish

(2020) I. Castanon et al.   Nature Communications

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

(2020) Sarah Alsamman et al.   Science Translational Medicine

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

(2019) Junsong Chen et al.   CURRENT CANCER DRUG TARGETS

Genetic and pharmacological inhibition of acid ceramidase prevents asymmetric cell division by neosis

(2019) Shai White-Gilbertson et al.   JOURNAL OF LIPID RESEARCH

Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP

(2019) Raj Pranap Arun et al.   Scientific Reports

When Three Isn't a Crowd: A Digyny Concept for Treatment-Resistant, Near-Triploid Human Cancers

(2019) Salmina et al.   Genes

The “life code”: a theory that unifies the human life cycle and the origin of human tumors

(2019) Liu Jinsong   SEMINARS IN CANCER BIOLOGY

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation

(2019) Ke-Chih Lin et al.   Jove-Journal of Visualized Experiments

Development of Fluorescently Labeled SSEA-3, SSEA-4, and Globo-H Glycosphingolipids for Elucidating Molecular Interactions in the Cell Membrane

(2019) Sachi Asano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transition of Mesenchymal and Epithelial Cancer Cells Depends on α1-4 Galactosyltransferase-Mediated Glycosphingolipids

(2018) Francis Jacob et al.   CANCER RESEARCH

UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells

(2018) Marthe-Susanna Wegner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates

(2018) Fang Li et al.   FASEB JOURNAL

Generation of erythroid cells from polyploid giant cancer cells: re-thinking about tumor blood supply

(2018) Zhigang Yang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Nuclear lipid mediators: Role of nuclear sphingolipids and sphingosine-1-phosphate signaling in epigenetic regulation of inflammation and gene expression

(2018) Panfeng Fu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice

(2018) Liansheng Zhong et al.   JOURNAL OF LIPID RESEARCH

Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis

(2018) Kristi Helke et al.   Scientific Reports

Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA–dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis

(2018) Rose Nganga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism

(2017) Rajesh K. Singh et al.   JOURNAL OF LIPID RESEARCH

Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells

(2017) N Niu et al.   ONCOGENE

Sphingosine 1-phosphate signaling through its receptor S1P5promotes chromosome segregation and mitotic progression

(2017) Guillaume Andrieu et al.   Science Signaling

Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype

(2017) Yuh-Jin Liang et al.   Oncotarget

Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis

(2017) Matthew J. Scheffel et al.   Scientific Reports

Sphingosine 1-phosphate signaling through its receptor S1P5promotes chromosome segregation and mitotic progression

(2017) Guillaume Andrieu et al.   Science Signaling

Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells

(2017) Michele Lai et al.   Scientific Reports

Defective ceramide synthases in mice cause reduced amplitudes in electroretinograms and altered sphingolipid composition in retina and cornea

(2016) Bianca Brüggen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Glycosphingolipid dynamics in human embryonic stem cell and cancer: their characterization and biomedical implications

(2016) Ming-Yi Ho et al.   GLYCOCONJUGATE JOURNAL

CerS6Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress

(2016) Baharan Fekry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity

(2016) Dominic Gosejacob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow

(2016) Hiroshi Watanabe et al.   MOLECULAR BIOLOGY OF THE CELL

Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity

(2016) Shih-Chi Yeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The enigma of ceramide synthase regulation in mammalian cells

(2016) Marthe-Susanna Wegner et al.   PROGRESS IN LIPID RESEARCH

Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner

(2016) Baharan Fekry et al.   PLoS One

The molecular medicine of acid ceramidase

(2015) Michael Frohbergh et al.   BIOLOGICAL CHEMISTRY

Docetaxel-induced polyploidization may underlie chemoresistance and disease relapse

(2015) Angela Ogden et al.   CANCER LETTERS

Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors

(2015) Mariona Rabionet et al.   HUMAN MOLECULAR GENETICS

Dihydroceramides: From Bit Players to Lead Actors

(2015) Monowarul Mobin Siddique et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chlamydia trachomatisInclusion Disrupts Host Cell Cytokinesis to Enhance Its Growth in Multinuclear Cells

(2015) He Song Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A Fraction of CD133+ CNE2 Cells Is Made of Giant Cancer Cells with Morphological Evidence of Asymmetric Mitosis

(2015) Qingping Jiang et al.   Journal of Cancer

Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia

(2014) Philipp Ebel et al.   BIOCHEMICAL JOURNAL

Ceramide Kinase Promotes Tumor Cell Survival and Mammary Tumor Recurrence

(2014) A. W. Payne et al.   CANCER RESEARCH

Dividing Cells Regulate Their Lipid Composition and Localization

(2014) G. Ekin Atilla-Gokcumen et al.   CELL

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

Plasma membrane phosphoinositide balance regulates cell shape duringDrosophilaembryo morphogenesis

(2014) Alessandra Reversi et al.   JOURNAL OF CELL BIOLOGY

Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development

(2014) Yuquan Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide

(2014) Qian He et al.   MOLECULAR BIOLOGY OF THE CELL

Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer

(2014) Jermaine Coward et al.   Frontiers in Oncology

Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal

(2013) Jekaterina Erenpreisa et al.   Cancer Cell International

Generation of erythroid cells from fibroblasts and cancer cells in vitro and in vivo

(2013) Shiwu Zhang et al.   CANCER LETTERS

DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells

(2013) Thomas R. Jackson et al.   CELL CYCLE

Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel

(2013) Shiwu Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Ablation of Ceramide Synthase 2 Causes Chronic Oxidative Stress Due to Disruption of the Mitochondrial Respiratory Chain

(2013) Hila Zigdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folate Stress Induces Apoptosis via p53-dependentde NovoCeramide Synthesis and Up-regulation of Ceramide Synthase 6

(2013) L. Alexis Hoeferlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse

(2013) Joseph C. Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of cancer stem-like cells through the formation of polyploid giant cancer cells

(2013) S Zhang et al.   ONCOGENE

Aneuploidy, polyploidy and ploidy reversal in the liver

(2013) Andrew W. Duncan   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sphingosine-1-phosphate inhibits ceramide-induced apoptosis during murine preimplantation embryonic development

(2013) Lei Guo et al.   THERIOGENOLOGY

PI 3-kinase-dependent phosphorylation of Plk1–Ser99 promotes association with 14-3-3γ and is required for metaphase–anaphase transition

(2013) Kousuke Kasahara et al.   Nature Communications

Nonmuscle myosin-2: mix and match

(2012) Sarah M. Heissler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Construction of Conditional Acid Ceramidase Knockout Mice andin vivoEffects on Oocyte Development and Fertility

(2012) Efrat Eliyahu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Polar expansion during cytokinesis

(2012) Heather F.M. Gudejko et al.   Cytoskeleton

Curvature, Lipid Packing, and Electrostatics of Membrane Organelles: Defining Cellular Territories in Determining Specificity

(2012) Joëlle Bigay et al.   DEVELOPMENTAL CELL

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

(2012) Suriyan Ponnusamy et al.   EMBO Molecular Medicine

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

(2012) Masayuki Nagahashi et al.   FASEB JOURNAL

Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes

(2012) Christina Ginkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Sphingomyelin-Rich Lipid Domains in the Accumulation of Phosphatidylinositol-4,5-Bisphosphate to the Cleavage Furrow during Cytokinesis

(2012) M. Abe et al.   MOLECULAR AND CELLULAR BIOLOGY

Ceramide biosynthesis and metabolism in trophoblast syncytialization

(2012) Ambika T. Singh et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis

(2012) Virginia Silió et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis

(2012) Nataliya Kotelevets et al.   PLoS One

Phosphatidylserine colocalizes with epichromatin in interphase nuclei and mitotic chromosomes

(2012) Igor Prudovsky et al.   Nucleus

Nuclear Sphingolipid Metabolism

(2011) Natasha C. Lucki et al.   Annual Review of Physiology

Loss of ceramide synthase 3 causes lethal skin barrier disruption

(2011) Richard Jennemann et al.   HUMAN MOLECULAR GENETICS

Inhibition of Glycosphingolipid Biosynthesis Induces Cytokinesis Failure

(2011) G. E. Atilla-Gokcumen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyploidy: The Link Between Senescence and Cancer

(2010) G. Mosieniak et al.   CURRENT PHARMACEUTICAL DESIGN

β4-Galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development

(2010) Toshikazu Nishie et al.   GLYCOBIOLOGY

A Critical Role for Ceramide Synthase 2 in Liver Homeostasis

(2010) Yael Pewzner-Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role for Ceramide Synthase 2 in Liver Homeostasis

(2010) Yael Pewzner-Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-muscle myosin II regulates survival threshold of pluripotent stem cells

(2010) Andrea Walker et al.   Nature Communications

Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domains

(2009) Philipp Rovina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Activation of Meiosis-Specific Genes Is Associated with Depolyploidization of Human Tumor Cells following Radiation-Induced Mitotic Catastrophe

(2009) F. Ianzini et al.   CANCER RESEARCH

The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: Possible role in regulating cell division

(2009) Laura Gillies et al.   CELLULAR SIGNALLING

The role of meiotic cohesin REC8 in chromosome segregation in γ irradiation-induced endopolyploid tumour cells

(2009) Jekaterina Erenpreisa et al.   EXPERIMENTAL CELL RESEARCH

Acid ceramidase improves the quality of oocytes and embryos and the outcome of in vitro fertilization

(2009) Efrat Eliyahu et al.   FASEB JOURNAL

Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer

(2009) Eugen Ruckhäberle et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

(2009) Xin Wang et al.   JOURNAL OF CELL BIOLOGY

Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies

(2009) Hyejung Park et al.   JOURNAL OF LIPID RESEARCH

Non-muscle myosin II takes centre stage in cell adhesion and migration

(2009) Miguel Vicente-Manzanares et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum

(2009) Christy A. Barlow et al.   TRENDS IN CELL BIOLOGY

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE