Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse

p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation

(2013) Gersende Alphonse et al.   BMC CANCER

Novel Agents Targeting Bioactive Sphingolipids for the Treatment of Cancer

(2013) A. Adan-Gokbulut et al.   CURRENT MEDICINAL CHEMISTRY

Outcome and Toxicity for Patients Treated with Intensity Modulated Radiation Therapy for Localized Prostate Cancer

(2013) Sujay A. Vora et al.   JOURNAL OF UROLOGY

Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B

(2012) Thomas H. Beckham et al.   INTERNATIONAL JOURNAL OF CANCER

Long-term Survival and Toxicity in Patients Treated With High-Dose Intensity Modulated Radiation Therapy for Localized Prostate Cancer

(2012) Daniel E. Spratt et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Intensity-Modulated Radiation Therapy, Proton Therapy, or Conformal Radiation Therapy and Morbidity and Disease Control in Localized Prostate Cancer

(2012) Gregg H. Goldin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer

(2012) L. Brizuela et al.   MOLECULAR CANCER THERAPEUTICS

Acid Ceramidase (ASAH1) Is a Global Regulator of Steroidogenic Capacity and Adrenocortical Gene Expression

(2012) Natasha C. Lucki et al.   MOLECULAR ENDOCRINOLOGY

Ablation of Dihydroceramide Desaturase Confers Resistance to Etoposide-Induced Apoptosis In Vitro

(2012) Monowarul M. Siddique et al.   PLoS One

AP-1 binding transcriptionally regulates human neutral ceramidase

(2011) Sean M. O’Neill et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Systems biology of the autophagy-lysosomal pathway

(2011) Anil G. Jegga et al.   Autophagy

Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for Monitoring Response

(2011) Sahar A. Saddoughi et al.   CLINICAL CANCER RESEARCH

Acid Ceramidase Expression Modulates the Sensitivity of A375 Melanoma Cells to Dacarbazine

(2011) Carmen Bedia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cost Implications of the Rapid Adoption of Newer Technologies for Treating Prostate Cancer

(2011) Paul L. Nguyen et al.   JOURNAL OF CLINICAL ONCOLOGY

Genomics and the Continuum of Cancer Care

(2011) Ultan McDermott et al.   NEW ENGLAND JOURNAL OF MEDICINE

The autophagic paradox in cancer therapy

(2011) W K K Wu et al.   ONCOGENE

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Ten-year outcomes of high-dose, intensity-modulated radiotherapy for localized prostate cancer

(2010) Zumre A. Alicikus et al.   CANCER

FTY720 (Fingolimod) Sensitizes Prostate Cancer Cells to Radiotherapy by Inhibition of Sphingosine Kinase-1

(2010) D. Pchejetski et al.   CANCER RESEARCH

Sphingosine-1-Phosphate Activates the AKT Pathway to Protect Small Intestines from Radiation-Induced Endothelial Apoptosis

(2010) S. Bonnaud et al.   CANCER RESEARCH

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells

(2010) Judith Mesicek et al.   CELLULAR SIGNALLING

Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes

(2010) Ruijuan Xu et al.   FASEB JOURNAL

Statin Use and Risk of Prostate Cancer Recurrence in Men Treated With Radiation Therapy

(2010) Ruchika Gutt et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide

(2010) Valérie Gouazé-Andersson et al.   PROSTATE

The cAMP-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cells

(2009) Natasha Lucki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Synthesis and bioevaluation of ω-N-amino analogs of B13

(2009) Aiping Bai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Diversity and Complexity of Ceramide Generation After Exposure of Jurkat Leukemia Cells to Irradiation

(2009) Dominique Ardail et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells

(2009) S White-Gilbertson et al.   ONCOGENE

Prevalence of Outpatient Cancer Treatment in the United States: Estimates from the Medical Panel Expenditures Survey (MEPS)

(2008) Michael T. Halpern et al.   CANCER INVESTIGATION

Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy

(2008) A. Apel et al.   CANCER RESEARCH

A role for ceramide in driving cancer cell resistance to doxorubicin

(2008) Yong-Yu Liu et al.   FASEB JOURNAL

Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

(2008) Ayman EM Mahdy et al.   MOLECULAR THERAPY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ceramide Biogenesis Is Required for Radiation-Induced Apoptosis in the Germ Line of C. elegans

(2008) X. Deng et al.   SCIENCE

Novel analogs of d-e-MAPP and B13. Part 2: Signature effects on bioactive sphingolipids

(2007) Alicja Bielawska et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel analogs of d-e-MAPP and B13. Part 1: Synthesis and evaluation as potential anticancer agents

(2007) Zdzislaw M. Szulc et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Long-Term Results of the M. D. Anderson Randomized Dose-Escalation Trial for Prostate Cancer

(2007) Deborah A. Kuban et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS