UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

(2017) et al.   Cancers

Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity

(2016) Dominic Gosejacob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The enigma of ceramide synthase regulation in mammalian cells

(2016) Marthe-Susanna Wegner et al.   PROGRESS IN LIPID RESEARCH

Tamoxifen regulation of sphingolipid metabolism—Therapeutic implications

(2015) Samy A.F. Morad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy

(2015) Jason Newton et al.   EXPERIMENTAL CELL RESEARCH

Sphingosine-1-phosphate receptor 1 transmits estrogens’ effects in endothelial cells

(2015) Olga Sukocheva et al.   STEROIDS

Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1

(2014) Faouzi Dahdouh et al.   ARCHIVES OF TOXICOLOGY

Ceramide Kinase Promotes Tumor Cell Survival and Mammary Tumor Recurrence

(2014) A. W. Payne et al.   CANCER RESEARCH

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

(2014) T Yabu et al.   CELL DEATH AND DIFFERENTIATION

Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function

(2014) Maria Laura Allende et al.   GLYCOCONJUGATE JOURNAL

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons

(2014) Wei Shen et al.   JOURNAL OF NEUROCHEMISTRY

Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer

(2014) Nicole Sänger et al.   Molecular Oncology

Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function

(2014) Frances Jane Sharom   Frontiers in Oncology

New insights on glucosylated lipids: Metabolism and functions

(2013) Yohei Ishibashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells

(2013) Bonggoo Park et al.   BMC Complementary and Alternative Medicine

Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing

(2013) Nicole Amen et al.   HUMAN MOLECULAR GENETICS

The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS

(2013) Daniela Hartmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cell-specific in vivo functions of glycosphingolipids: Lessons from genetic deletions of enzymes involved in glycosphingolipid synthesis

(2013) Richard Jennemann et al.   PROGRESS IN LIPID RESEARCH

Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth

(2012) Daniela Hartmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sphingomyelin synthase 1 activity is regulated by theBCR-ABLoncogene

(2012) Tara Ann Burns et al.   JOURNAL OF LIPID RESEARCH

Doxorubicin Influences the Expression of Glucosylceramide Synthase in Invasive Ductal Breast Cancer

(2012) Xiaofang Zhang et al.   PLoS One

D,L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein expression in A549 cells

(2011) Mototeru Yamane et al.   BIOCHIMIE

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Lipid rafts: signaling and sorting platforms of cells and their roles in cancer

(2011) Simon Staubach et al.   Expert Review of Proteomics

Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association

(2010) Kristina R. Rogers et al.   CARCINOGENESIS

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells

(2010) Judith Mesicek et al.   CELLULAR SIGNALLING

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling

(2010) Yong-Yu Liu et al.   Molecular Cancer

Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias

(2008) W. J. Kim et al.   BLOOD

Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage

(2008) Duska Separovic et al.   EXPERIMENTAL CELL RESEARCH

Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells

(2008) Z.-X. Jin et al.   INTERNATIONAL IMMUNOLOGY

c-Fos Activates Glucosylceramide Synthase and Glycolipid Synthesis in PC12 Cells

(2008) Pilar M. Crespo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY